公开(公告)号：DE2329037A1

公开(公告)日：1974-12-19

申请号：DE2329037

申请日：1973-06-07

Applicant: BASF AG

Inventor： AMANN AUGUST DR MED ,  VILHUBER HEINZ GEORG DIPL CHEM ,  KUNZE JOHANNES DR MED ,  GIERTZ HUBERT PROF DR MED ,  FRANKE ALBRECHT DIPL CHEM DR

IPC: C07C51/00 ,  C07C51/15 ,  C07C57/38 ,  C07C57/42 ,  C07C57/58 ,  C07C59/48 ,  C07C59/64 ,  C07C67/00 ,  C07C231/00 ,  C07C231/10 ,  C07C231/12 ,  C07C233/11 ,  C07C235/32 ,  C07C235/34 ,  C07C253/00 ,  C07C255/37 ,  C07D295/185 ,  C07C103/22 ,  A61K27/00 ,  C07C63/52 ,  C07D29/20 ,  C07D87/34

公开(公告)号：DE2306543A1

公开(公告)日：1974-08-15

申请号：DE2306543

申请日：1973-02-10

Applicant: BASF AG

Inventor： AMANN AUGUST DR MED ,  KOENIG HORST DR ,  GIERTZ HUBERT PROF DR MED ,  KRETZSCHMAR ROLF DR MED ,  CHIEME PETER DR

IPC: A61K31/41 ,  A61K31/425 ,  C07D285/12 ,  C07D285/125 ,  A61K27/00

公开(公告)号：DE2335437A1

公开(公告)日：1974-01-31

申请号：DE2335437

申请日：1973-07-12

Applicant: BASF AG

Inventor： AMANN AUGUST DR MED ,  SCHUSTER JOERG DR MED ,  GIERTZ HUBERT PROF DR MED ,  AQUILA WERNER DIPL-CHEM DR ,  HIMMELE WALTER DIPL-CHEM DR ,  SIEGEL HARDO DIPL-CHEM DR

IPC: C07D295/02 ,  C07D295/03 ,  C07D29/10

Abstract: N-(1-Indanylmethyl)-2,6-dimethylpiperidine, which can e.g. be prepd. by reacting 1-formyl-indane with 2,6-dimethylpiperidine and catalytically hydrogenating the resulting enamine, and its salts have hypotensive activity 5-10 times greater than that of the corresp. cpds. with only one or no methyl gp. in the piperidine ring.

公开(公告)号：DE2408288A1

公开(公告)日：1975-09-04

申请号：DE2408288

申请日：1974-02-21

Applicant: BASF AG

Inventor： AMANN AUGUST DR MED ,  KOENIG HORST DIPL CHEM DR ,  THIEME PETER C DIPL CHEM DR ,  GIERTZ HUBERT PROF DR MED ,  KRETZSCHMAR ROLF DR

IPC: C07D285/12 ,  A61K31/41 ,  A61K31/433 ,  A61P25/08 ,  C07D285/125

Abstract: 1494757 1,3,4-Thiadiazolium compounds BASF AG 20 Feb 1975 [21 Feb 1974] 7106/75 Heading C2C The invention comprises novel compounds (I) in which (a) R 2 , R 3 , R 4 , R 5 and R 6 are identical or different and are hydrogen, fluorine, chlorine, bromine, iodine, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms in the alkyl moiety, trifluoromethyl or NO 2 , at least one of the substituents R 2 to R 6 being different from hydrogen, and R 1 is alkyl or 2 to 6 carbon atoms which is optionally substituted by OH, CN, phenyl or cycloalkyl of 3 to 6 carbon atoms in the ring, or (b) R 1 is methyl optionally substituted by phenyl or cycloalkyl of 3 to 6 carbon atoms in the ring when at least two of R 2 to R 6 are different from hydrogen, or, when R 2 , R 3 , R 5 and R 6 have the above meanings, R 4 is hydrogen, fluorine, bromine, iodine, alkyl of 2 to 4 carbon atoms, alkoxy of 2 to 4 carbon atoms in the alkyl moiety, trifluoromethyl or NO 2 and at least one of R 2 , R 3 , R 4 , R 6 and R 6 is different from H, or (c) R 2 , R 3 , R 4 , R 5 and R 6 are each hydrogen when R 1 is alkyl of 3 to 6 carbon atoms which is optionally substituted by OH, CN, phenyl or cycloalkyl of 3 to 6 carbon atoms in the ring or when R 1 is ethyl which is #-substituted by OH, CN, phenyl or cycloalkyl of 3 to 6 carbon atoms in the ring, or (d) R 1 is methyl substituted by cycloalkyl of 3 to 6 carbon atoms in the ring when R 2 , R 3 , R 4 , R 5 and R 6 are each hydrogen or R 2 , R 3 , R 5 and R 6 are hydrogen and R 4 is chlorine. They are made by reacting compounds (II) (obtained by reacting compounds III with R 1 NHNH 2 ; the free acids corresponding to III are also prepared as are compounds IV) with carbon disulphide or thiophosgene. Pharmaceutical preparations having anticonvulsive action contain (I) as active ingredient. Administration is preferably orally.

公开(公告)号：DE2328758A1

公开(公告)日：1975-01-09

申请号：DE2328758

申请日：1973-06-06

Applicant: BASF AG

Inventor： AMANN AUGUST DR MED ,  GIERTZ HUBERT PROF DR MED ,  FRANKE ALBRECHT DIPL CHEM DR

IPC: C07D295/084 ,  C07D303/04 ,  C07D317/58 ,  C07C91/16 ,  A61K31/135

Abstract: Cpds (I) and their physiologically compatible acid addn salts: (where 1=H or 1-4C alkyl, R2=1-8C alkyl (may be substd with -OH or aromatic gps) or the whole gp. -NR1R2 forms a 5-8 membered heterocyclic ring (which may contain another heteroatom and may be substd)), have pharmacological props. e.gg. spasmolytic action, action on the central nervous system and antidepressive effects. They may be used in suitable pharmaceutical prepns.

公开(公告)号：DE2310141A1

公开(公告)日：1974-09-12

申请号：DE2310141

申请日：1973-03-01

Applicant: BASF AG

Inventor： KOENIG HORST DIPL CHEM DR ,  THIEME PETER C DIPL CHEM DR ,  GIERTZ HUBERT PROF DR MED

IPC: C07C67/00 ,  C07C213/00 ,  C07C215/60 ,  C07D319/08 ,  C07C91/34 ,  A61K27/00

公开(公告)号：DE2309639A1

公开(公告)日：1974-09-12

申请号：DE2309639

申请日：1973-02-27

Applicant: BASF AG

Inventor： AMANN AUGUST DR MED ,  KOENIG HORST DIPL CHEM DR ,  THIEME PETER C DIPL CHEM DR ,  GIERTZ HUBERT PROF DR MED

IPC: A01N43/32 ,  C07C45/75 ,  C07C49/82 ,  C07D319/08 ,  C07D15/08 ,  A01N9/28 ,  A61L13/00

公开(公告)号：CH599190A5

公开(公告)日：1978-05-12

申请号：CH1237474

申请日：1974-09-11

Applicant: BASF AG

Inventor： AMANN AUGUST DR MED ,  BOLZ GERHARD DR ,  WIERSDORFF WALTER-WIELANT DR ,  GIERTZ HUBERT PROF DR MED ,  WILSMANN KLAUS DR MED

IPC: C07D307/77 ,  A61K20060101 ,  A61K31/27 ,  A61K31/34 ,  A61K31/365 ,  C07D20060101 ,  C07D307/89 ,  C07D307/93

公开(公告)号：DE2346305A1

公开(公告)日：1975-04-03

申请号：DE2346305

申请日：1973-09-14

Applicant: BASF AG

Inventor： AMANN AUGUST DR MED ,  BOLZ GERHARD DIPL CHEM DR ,  WIERSDORFF WALTER-WIELANT DIPL ,  GIERTZ HUBERT PROF DR MED ,  WILSMANN KLAUS DR MED

IPC: C07D307/77 ,  A61K20060101 ,  A61K31/27 ,  A61K31/34 ,  A61K31/365 ,  C07D20060101 ,  C07D307/89 ,  C07D307/93

公开(公告)号：DE2310140A1

公开(公告)日：1974-09-12

申请号：DE2310140

申请日：1973-03-01

Applicant: BASF AG

Inventor： AMANN AUGUST DR MED ,  THIEME PETER C DIPL CHEM DR ,  GIERTZ HUBERT PROF DR MED ,  KOENIG HORST DIPL-CHEM DR

IPC: C07C45/75 ,  C07D319/08 ,  C07C91/24 ,  A61K27/00

Abstract: Cpds. of formula (I) (where R1 is H or 1-4C alkyl; R2 is 1-6C alkyl; or R1 + R2 is -(CH2)n- in which n is 3, 4, 5 or 6; and m is 0 or 1) and their pharmacologically tolerable salts, which are useful as bronchodilators, are prepd. by reacting an epoxide of formula (II) (where R3 and R4 are H or 1-4C alkyl or R3 + R4 is -(CH2)n- in which n is 3, 4 or 5) with an amine H2N-CR1R2-(CH2)m-C CH and hydrolysing the reaction prod.