公开(公告)号：DE2456958A1

公开(公告)日：1976-06-16

申请号：DE2456958

申请日：1974-12-03

Applicant: BASF AG

Inventor： AMANN AUGUST DR MED ,  VILHUBER HEINZ GEORG DIPL CHEM ,  KUNZE JOHANNES DR MED ,  GIERTZ HUBERT PROF DR MED ,  FRAKE ALBRECHT DIPL CHEM DR

IPC: A61K31/275 ,  C07C29/147 ,  C07C67/00 ,  C07C253/00 ,  C07C255/32 ,  C07C255/33 ,  C07C121/66

公开(公告)号：DE2854475A1

公开(公告)日：1980-07-03

申请号：DE2854475

申请日：1978-12-16

Applicant: BASF AG

Inventor： THYES MARCO DIPL CHEM DR ,  GRIES JOSEF DR MED ,  LEHMANN HANS DIETER DR MED ,  LENKE DIETER PROF DR ,  KUNZE JOHANNES DR MED

IPC: A61K31/50 ,  A61K31/395 ,  A61K31/502 ,  A61P7/02 ,  A61P9/12 ,  C07C62/38 ,  C07C205/56 ,  C07D231/54 ,  C07D237/26 ,  A61K31/52

Abstract: 2-Aryl-3,4-diaza-bicyclo-[4.1.0]hept-2-en-5-ones, substituted in the phenyl ring, of the general formula their preparation, and therapeutic agents, containing these compounds, which may be used for the treatment of hypertension or of thrombo-embolic disorders.

公开(公告)号：DE2854191A1

公开(公告)日：1980-07-03

申请号：DE2854191

申请日：1978-12-15

Applicant: BASF AG

Inventor： THYES MARCO DIPL CHEM DR ,  GRIES JOSEF DR MED ,  LEHMANN HANS DIETER DR MED ,  LENKE DIETER PROF DR ,  KUNZE JOHANNES DR MED

IPC: A61K31/50 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04

公开(公告)号：DE2727481A1

公开(公告)日：1979-01-11

申请号：DE2727481

申请日：1977-06-18

Applicant: BASF AG

Inventor： LEBKUECHER ROLF ,  THYES MARCO DIPL CHEM DR ,  KOENIG HORST DIPL CHEM DR ,  LEHMANN HANS DIETER DR MED ,  GRIES JOSEF DR MED ,  LENKE DIETER PROF DR ,  KUNZE JOHANNES DR MED

IPC: C07D237/00 ,  A61K31/50 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04

Abstract: 6-(p-Acylaminophenyl)-4,5-dihydropyridaz-3-ones of the formula I I where R1 is hydrogen or alkyl of 1 to 3 carbon atoms and R2, if R1 is hydrogen, is halogen-substituted alkyl of 3 to 6 carbon atoms or beta -haloethyl or, if R1 is alkyl of 1 to 3 carbon atoms, is halogen-substituted alkyl of 1 to 6 carbon atoms, their manufacture, and therapeutic agents which contain, as the active ingredient, a compound of the formula I, where R2 may also be halomethyl or alpha -haloethyl if R1 is hydrogen. These compounds may be used as anti-hypertensive agents and for the prophylaxis and therapy of thromboembolic disorders.

公开(公告)号：DE2329037A1

公开(公告)日：1974-12-19

申请号：DE2329037

申请日：1973-06-07

Applicant: BASF AG

Inventor： AMANN AUGUST DR MED ,  VILHUBER HEINZ GEORG DIPL CHEM ,  KUNZE JOHANNES DR MED ,  GIERTZ HUBERT PROF DR MED ,  FRANKE ALBRECHT DIPL CHEM DR

IPC: C07C51/00 ,  C07C51/15 ,  C07C57/38 ,  C07C57/42 ,  C07C57/58 ,  C07C59/48 ,  C07C59/64 ,  C07C67/00 ,  C07C231/00 ,  C07C231/10 ,  C07C231/12 ,  C07C233/11 ,  C07C235/32 ,  C07C235/34 ,  C07C253/00 ,  C07C255/37 ,  C07D295/185 ,  C07C103/22 ,  A61K27/00 ,  C07C63/52 ,  C07D29/20 ,  C07D87/34