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    2.
    发明专利
    未知

    公开(公告)号：DE59107467D1

    公开(公告)日：1996-04-04

    申请号：DE59107467

    申请日：1991-11-29

    Applicant: BASF AG

    Inventor： HUELLMANN MICHAEL DR ,  GNAD JOSEF DR ,  BECKER RAINER DR

    IPC: C07C51/377 ,  C07C57/44 ,  C07C59/64 ,  C07C59/66 ,  C07C67/327 ,  C07C67/46 ,  C07C69/734 ,  A61K7/40

    Abstract: 3-Arylacrylic acids and their derivatives I in which Ar represents an aryl radical which can additionally have substituents which do not react with ketene and which are stable to acids and bases under the conditions of the reaction described below, and R denotes hydrogen, alkali metal, alkaline earth metal, ammonium or a C1- to C20-alkyl group, are prepared by reacting, in a first reaction step, a dialkyl acetal of an aromatic aldehyde II in which R represents C1- to C4-alkyl, with ketene CH2=C=O in the presence of catalytic amounts of a protonic acid or a Lewis acid to give a 3-arylpropionic acid derivative III and reacting this intermediate III, in a second reaction step, in the presence of acid or base and, additionally in the case where R denotes a C1- to C20-alkyl group, with a C1- to C20-alkanol to give the end product I.

    6.
    发明专利
    未知

    公开(公告)号：DE4039782A1

    公开(公告)日：1992-06-17

    申请号：DE4039782

    申请日：1990-12-13

    Applicant: BASF AG

    Inventor： HUELLMANN MICHAEL DR ,  GNAD JOSEF DR ,  BECKER RAINER DR

    IPC: C07C51/377 ,  C07C57/44 ,  C07C59/64 ,  C07C59/66 ,  C07C67/327 ,  C07C67/46 ,  C07C69/734

    Abstract: 3-Arylacrylic acids and their derivatives I in which Ar represents an aryl radical which can additionally have substituents which do not react with ketene and which are stable to acids and bases under the conditions of the reaction described below, and R denotes hydrogen, alkali metal, alkaline earth metal, ammonium or a C1- to C20-alkyl group, are prepared by reacting, in a first reaction step, a dialkyl acetal of an aromatic aldehyde II in which R represents C1- to C4-alkyl, with ketene CH2=C=O in the presence of catalytic amounts of a protonic acid or a Lewis acid to give a 3-arylpropionic acid derivative III and reacting this intermediate III, in a second reaction step, in the presence of acid or base and, additionally in the case where R denotes a C1- to C20-alkyl group, with a C1- to C20-alkanol to give the end product I.

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