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公开(公告)号：JPH10182540A
公开(公告)日：1998-07-07
申请号：JP33875297
申请日：1997-12-09
Applicant: BASF AG
Inventor： GROENING CARSTEN , THERRE JOERG , KAIBEL GERD , EBEL KLAUS
Abstract: PROBLEM TO BE SOLVED: To provide a new method for industrially advantageously producing a glyoxal monoacetal, enabling to profitably obtain the glyoxal monoacetal by reacting glyoxal and a glyoxal bisacetal with an alcohol under a specific reaction condition. SOLUTION: This method for producing a glyoxal monoacetal of formula I (R , R are each a 1-4C alkyl, a 2-4C alkenyl) comprises reacting the mixture of glyoxal with a glyoxal bisacetal of formula II with an excessive amount of an alcohol of the formula: R OH or R OH or their mixture in the presence of an acidic catalyst until the equilibrium of the reaction is achieved. The acidic catalyst is preferably an acidic ion exchange material, especially preferably the fixed bed of the acidic ion exchange material. The alcohol is preferably methanol. The glyoxal bisacetal, the acidic catalyst and the alcohol are preferably reutilized for the reaction.
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公开(公告)号：JPH0912558A
公开(公告)日：1997-01-14
申请号：JP15990096
申请日：1996-06-20
Applicant: BASF AG
Inventor： SCHNEIDER REGINA , MELDER JOHANN-PETER , TELES JOAQUIM HENRIQUE , GROENING CARSTEN , EBEL KLAUS
IPC: C07C257/22 , C07D249/08 , C07D249/12
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公开(公告)号：CA2667559A1
公开(公告)日：2008-05-15
申请号：CA2667559
申请日：2007-11-05
Applicant: BASF AG
Inventor： GROENING CARSTEN , KEIL MICHAEL , KUHN OLIVER , LONGLET JON J , SUKOPP MARTIN
IPC: C07D231/44 , A01N43/00 , A01N43/56 , A61K31/415 , A61P33/00
Abstract: The present invention relates to a process for the sulfinylation of a pyr azole derivative, characterized in that 5-amino-1-[2,6-dichloro-4-(trifluoro methyl)phenyl]-1H-pyrazole-3- carbonitrile (II) is reacted with a sulfinylat ing agent selected from trifluoromethylsulfinic acid, trifluoromethylsulfini c acid anhydride, and a trifluoromethylsulfinate alkaline or alkaline earth metal salt and mixtures of the acid and/or the salt(s), in the presence of a t least one amine acid complex wherein the amine(s) are selected from tertia ry amines and the acid(s) are selected from hydrofluoric, hydrochloric, hydr obromic and hydroiodic acid and sulfonic acid derivatives, and with the addi tion of a halogenating agent.
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公开(公告)号：DE19858360A1
公开(公告)日：2000-06-21
申请号：DE19858360
申请日：1998-12-17
Applicant: BASF AG
Inventor： GROENING CARSTEN , KEMPER REINHARD , FREDE MARKUS , EBEL KLAUS
IPC: C07D207/32 , C07D207/323 , C07D207/416
Abstract: In the preparation of 2,4-dimethyl-pyrrole (I) by hydrolysis of 2,4-dimethyl-3,5-bis-alkoxycarbonyl-pyrrole (II) to the dicarboxylic acid (III) with strong alkali and thermal decarboxylation of (III), (II) is heated under reflux with 10-30% aqueous alkali hydroxide, and then neutralized with acid. Heating under reflux is continued to complete decarboxylation.
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公开(公告)号：DE19858352A1
公开(公告)日：2000-06-21
申请号：DE19858352
申请日：1998-12-17
Applicant: BASF AG
Inventor： GROENING CARSTEN , KEMPER REINHARD , FREDE MARKUS , EBEL KLAUS
IPC: C07D241/06 , B01J23/44 , C07B61/00 , C07D207/34 , C07D207/416
Abstract: In the preparation of 2,4-dimethyl-3,5-bis-alkoxycarbonyl-pyrroles (I) by nitrosing an alkyl acetoacetate (II) to the alkyl 2-nitrosoacetoacetate (III), reducing (III) to the amine (IV) and ring-closing condensation with unsubstituted (II), (III) is hydrogenated with hydrogen in the presence of a noble metal catalyst and condensed with (II) without isolating (IV).
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Patent Agency Ranking
公开(公告)号：DE19651325A1
公开(公告)日：1998-06-18
申请号：DE19651325
申请日：1996-12-11
Applicant: BASF AG
Inventor： GROENING CARSTEN , THERRE JOERG , KAIBEL GERD , EBEL KLAUS
Abstract: Preparation of glyoxal monoacetals of formula (I) comprises reacting a mixture of glyoxal and glyoxal bis-acetals of formula (II) with an excess of alcohol(s) R OH and/or R OH in the presence of an acid catalyst until equilibrium is attained. R1,R2 = 1-4C alkyl or 2-4C alkenyl, preferably methyl.
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公开(公告)号：CA2667565A1
公开(公告)日：2008-05-15
申请号：CA2667565
申请日：2007-11-05
Applicant: BASF AG
Inventor： KUHN OLIVER , SUKOPP MARTIN , GROENING CARSTEN , LONGLET JON J , KEIL MICHAEL
IPC: C07D231/44 , A01N43/00 , A01N43/56 , A61K31/415 , A61P33/00
Abstract: The present invention relates to a process for the sulfinylation of a pyr azole derivative, characterized in that 5-amino-1-[2,6-dichloro-4-(trifluoro methyl)phenyl]-1H-pyrazole-3-carbonitrile (II) is reacted with a sulfinylati ng agent S in the presence of at least one amine acid complex wherein the am ine(s) are selected from secondary and/or tertiary amines and the acid(s) ar e selected from hydrofluoric, hydrochloric, hydrobromic and hydroiodic acid and sulfonic acid derivatives, and with the addition of a halogenating agent , wherein S is [CF3S(O)]2O; or CF3S(O)X wherein X means fluoro, chloro, brom o, iodo, a hydroxy group, or an alkaline or alkaline earth metal salt of the hydroxy group; or mixtures thereof, wherein the temperature of the reaction mixture at no time exceeds 39°C.
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公开(公告)号：DE59603698D1
公开(公告)日：1999-12-30
申请号：DE59603698
申请日：1996-06-18
Applicant: BASF AG
Inventor： SCHNEIDER REGINA , MELDER JOHANN-PETER , TELES JOAQUIM HENRIQUE , GROENING CARSTEN , EBEL KLAUS
IPC: C07C257/22 , C07D249/08 , C07D249/12
Abstract: Prepn. of 1,2,4-triazolium salts of formula (Ia) and 1,2,4-triazolines of formula (Ib) comprises (a) reacting an amidrazone of formula (R )(NHR )C=N-NHR (II) with a carboxylic acid of formula R COOH (III) or its functional deriv. (IIIa) to give (Ia; A = anion of (III)), opt. followed by exchanging the anion for another A; and opt. (b) reacting (Ia), without isolation, with an alcohol or thiol cpd. of formula X-Y-R (IV) to give (Ib). R -R , R = organic gps., where R , R may be linked to form a 5-8 membered ring; R = H or organic gp.; A = 1 equiv. of an anion; Y = O or S ; X = H, alkali metal or alkaline earth metal.
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公开(公告)号：DE19522715A1
公开(公告)日：1997-01-02
申请号：DE19522715
申请日：1995-06-22
Applicant: BASF AG
Inventor： SCHNEIDER REGINA , MELDER JOHANN-PETER , TELES JOAQUIM HENRIQUE , GROENING CARSTEN , EBEL KLAUS
IPC: C07C257/22 , C07D249/08 , C07D249/12 , C07D249/16 , B01J31/02
Abstract: Prepn. of 1,2,4-triazolium salts of formula (Ia) and 1,2,4-triazolines of formula (Ib) comprises (a) reacting an amidrazone of formula (R )(NHR )C=N-NHR (II) with a carboxylic acid of formula R COOH (III) or its functional deriv. (IIIa) to give (Ia; A = anion of (III)), opt. followed by exchanging the anion for another A; and opt. (b) reacting (Ia), without isolation, with an alcohol or thiol cpd. of formula X-Y-R (IV) to give (Ib). R -R , R = organic gps., where R , R may be linked to form a 5-8 membered ring; R = H or organic gp.; A = 1 equiv. of an anion; Y = O or S ; X = H, alkali metal or alkaline earth metal.
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公开(公告)号：DE10026141A1
公开(公告)日：2001-11-29
申请号：DE10026141
申请日：2000-05-26
Applicant: BASF AG
Inventor： WEIGL HAGEN , EBEL KLAUS , HIEBER GISELA , SCHULZ GERHARD , GROENING CARSTEN
IPC: C07C51/285 , C07C51/43 , C07C59/01 , C07C59/10
Abstract: The invention relates to a method for producing poly or monomethylol alkanoic acids of general formula (I), wherein R can be the same or different and means a substituted or unsubstituted aliphatic hydrocarbon or a methylol group, from the corresponding poly or monomethylol alkanals of general formula (II), R having the meaning given above, by oxidation with hydrogen peroxide. A differentiation is made between a starting phase and an end phase of the reaction, the reaction temperature selected during the starting phase being lower than that selected during the end phase and being at least >/= 40 DEG C to 85 DEG C, preferably 60 to 80 DEG C, especially preferably 65-75 DEG C, and the temperature during the end phase being > 85 DEG C-110 DEG C, preferably up to 105 DEG C. The method is used especially for producing dimethylol alkanoic acids from the corresponding dimethylol alkanals, especially for producing dimethylol butanal or dimethylol propanal.
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