公开(公告)号：DE4216941A1

公开(公告)日：1993-11-25

申请号：DE4216941

申请日：1992-05-22

Applicant: BASF AG

Inventor： HELLENDAHL BEATE DR ,  ROEHL FRANZ DR ,  RASCHACK MANFRED DR ,  HAFNER MATTHIAS DR

IPC: C07C211/49 ,  C07C215/50 ,  C07C217/58 ,  C07C219/28 ,  C07C233/43 ,  C07D521/00 ,  A61K31/135

Abstract: Para-substitued benzyl amines of general formula (I) in which W is a carbonyl group or a single bond, R is a lower alkyl group, R is an alkyl radical with 5 to 20 carbon atoms which may be branched and contain 1 to 3 double bonds, in addition a saturated cycle of 3 to 7 carbon atoms may be integrated into the chain or included as substituents, and may be substitued by one or more aromatic rings and contain a sulphur or oxygen atom, X is a group of the general formula: OR or NR R in which R stands for a lower alkyl, lower alkyl carbonyl, lower alkoxycarbonyl, mono lower alkyl aminocarbonyl, di lower alkyl aminocarbonyl group or a hydrogen atom, R is a lower alkyl group or a hydrogen atom and R is a hydrogen atom, a lower alkyl, lower alkyl carbonyl, lower alkoxy carbonyl, aminocarbonyl, mono lower alkyl aminocarbonyl or di lower alkyl aminocarbonyl group, Y is a hydrogen atom or a methyl group, and addition salts with physiologically acceptable acids and medicaments containing them.

公开(公告)号：DE4216942A1

公开(公告)日：1993-11-25

申请号：DE4216942

申请日：1992-05-22

Applicant: BASF AG

Inventor： HELLENDAHL BEATE DR ,  SCHLECKER RAINER DR ,  ROEHL FRANZ DR ,  ZIPPLIES MATTHIAS DR ,  RASCHACK MANFRED DR ,  HAFNER MATTHIAS DR

IPC: A61K31/47 ,  A61K31/472 ,  A61P9/00 ,  A61P31/04 ,  C07D217/04 ,  C07D217/06

Abstract: Medicament for oral administration which contains as active substance per individual dose, besides the customary galenic auxiliaries, 10 to 1000 mg of a compound of general formula (I) or (II) in which W is a carbonyl group or a single bond, R is a hydrogen atom or a group of the general formula R CO in which R is a lower alkyl, lower alkoxy, mono lower alkylamino or di lower alkylamino group, R is an alkyl residue with 3 to 20 carbon atoms which may be branched or unbranched and contain 1 to 3 double bonds, a saturated cycle of 3 to 7 carbon atoms integrated into the chain or as substituent, or may be substituted by one or more aromatic rings or contain an oxygen or sulphur atom, as a racemate and as isolated enantiomers; or the addition salt thereof with a physiologically acceptable acid, and the active substances themselves insofar as they are novel.