公开(公告)号：AT165813T

公开(公告)日：1998-05-15

申请号：AT95112356

申请日：1992-01-24

Applicant: BASF AG

Inventor： GRAMMENOS WASSILIOS DR ,  HARREUS ALBRECHT DR ,  SAUTER HUBERT DR ,  HELLENDAHL BEATE DR ,  DOETZER REINHARDT DR ,  AMMERMANN EBERHARD DR ,  LORENZ GISELA DR

IPC: A01N37/50 ,  A01N43/54 ,  A01N43/58 ,  A01N43/76 ,  A01N43/836 ,  C07C69/65 ,  C07C69/653 ,  C07C69/734 ,  C07C69/738 ,  C07C251/48 ,  C07C251/50 ,  C07C251/52 ,  C07C251/54 ,  C07C251/56 ,  C07C251/58 ,  C07C251/60 ,  C07C251/86 ,  C07C255/15 ,  C07C255/57 ,  C07C255/58 ,  C07C255/62 ,  C07D213/77 ,  C07D239/42 ,  C07D241/20 ,  C07D263/32 ,  C07D333/28

Abstract: Iminoalkyl-phenylacrylic acid derivs. (I) ar new: R = H or 1-6C alkyl; R = H; 1-4C alkyl opt. substd. by halo; or opt. substd. aryl; Z ,Z = H; halo; CN; NO2;etc.;Y = O; NH; or NR ; and R = H; 1-4C alkoxycarbonyl-1-4C alkyl; or opt. substd. alkyl, cycloalkyl, etc.; or Y+R form a ring which is opt. substd. when Y = NH or NR ; R = 1-6C alkyl; X = CH-1-4C alkoxy or CH-1-4C alkylthio (also 1-4C alkylidene and 1-4C alkoxyimino in the description).

公开(公告)号：AT165352T

公开(公告)日：1998-05-15

申请号：AT96101050

申请日：1993-07-31

Applicant: BASF AG

Inventor： WINGERT HORST DR ,  HELLENDAHL BEATE DR ,  KIRSTGEN REINHARD DR ,  SAUTER HUBERT DR ,  AMMERMANN EBERHARD DR ,  LORENZ GISELA DR

IPC: A01N37/42 ,  A01N37/10 ,  A01N37/34 ,  A01N37/36 ,  A01N37/50 ,  A01N43/10 ,  A01N43/40 ,  A01N43/78 ,  A01N43/80 ,  A01N43/84 ,  A01N55/00 ,  C07C69/618 ,  C07C69/734 ,  C07C69/738 ,  C07C69/76 ,  C07C205/56 ,  C07C233/31 ,  C07C233/54 ,  C07C251/48 ,  C07C255/23 ,  C07C255/62 ,  C07C323/57 ,  C07C323/60 ,  C07D213/54 ,  C07D213/55 ,  C07D213/56 ,  C07D215/12 ,  C07D217/16 ,  C07D231/12 ,  C07D233/92 ,  C07D261/08 ,  C07D271/10 ,  C07D271/107 ,  C07D277/20 ,  C07D277/22 ,  C07D277/58 ,  C07D277/66 ,  C07D285/12 ,  C07D307/54 ,  C07D307/71 ,  C07D317/60 ,  C07D319/18 ,  C07D333/24 ,  C07D333/28 ,  C07D333/38 ,  C07D333/42 ,  C07D413/12 ,  C07D521/00 ,  C07F7/10 ,  C07F7/22

Abstract: Acetylene derivatives of the general formula I in which U, V and W denote hydrogen, halogen, nitro, cyano, alkyl and alkoxy, A denotes alkylidene, alkoxymethylidene, alkylthiomethylidene and alkoximino, B denotes OH, alkoxy and alkylamino and R denotes hydrogen, halogen, cyano, CF3, alkyl, cycloalkyl, haloalkyl, aryl, alkenyl, alkinyl, heterocyclyl, heteroaryl, arylalkyl, arylalkenyl, arylethinyl, heteroaryl-C1-C4-alkyl, C1-C4-alkoxy-C1-C4-alkyl, aryloxyalkyl, heteroaryloxyalkyl, arylamino-alkyl, arylthiomethyl, heteroarylthiomethyl, C(O)R , C(O)NR R , C(S)NR R , C(O)SR , C(S)OR , C(S)SR , CH(OH)R )R , SiR R R , SnR R R , C(OR)R , C(=N-OR )R , and the radicals R -R , R and R denote hydrogen, alkyl, aryl, heteroaryl, arylalkyl and heteroarylalkyl, and fungicides containing these compounds.

公开(公告)号：AT138906T

公开(公告)日：1996-06-15

申请号：AT92101121

申请日：1992-01-24

Applicant: BASF AG

Inventor： GRAMMENOS WASSILIOS DR ,  HARREUS ALBRECHT DR ,  SAUTER HUBERT DR ,  HELLENDAHL BEATE DR ,  DOETZER REINHARD DR ,  AMMERMANN EBERHARD DR ,  LORENZ GISELA DR

IPC: A01N37/50 ,  A01N43/54 ,  A01N43/58 ,  A01N43/76 ,  A01N43/836 ,  C07C69/65 ,  C07C69/653 ,  C07C69/734 ,  C07C69/738 ,  C07C251/48 ,  C07C251/50 ,  C07C251/52 ,  C07C251/54 ,  C07C251/56 ,  C07C251/58 ,  C07C251/60 ,  C07C251/86 ,  C07C255/15 ,  C07C255/57 ,  C07C255/58 ,  C07C255/62 ,  C07D213/77 ,  C07D239/42 ,  C07D241/20 ,  C07D263/32 ,  C07D333/28

Abstract: Iminoalkyl-phenylacrylic acid derivs. (I) ar new: R = H or 1-6C alkyl; R = H; 1-4C alkyl opt. substd. by halo; or opt. substd. aryl; Z ,Z = H; halo; CN; NO2;etc.;Y = O; NH; or NR ; and R = H; 1-4C alkoxycarbonyl-1-4C alkyl; or opt. substd. alkyl, cycloalkyl, etc.; or Y+R form a ring which is opt. substd. when Y = NH or NR ; R = 1-6C alkyl; X = CH-1-4C alkoxy or CH-1-4C alkylthio (also 1-4C alkylidene and 1-4C alkoxyimino in the description).

公开(公告)号：DE4425146A1

公开(公告)日：1996-01-18

申请号：DE4425146

申请日：1994-07-15

Applicant: BASF AG

Inventor： HELLENDAHL BEATE DR ,  LANSKY ANNEGRET DR ,  RENDENBACH-MUELLER BEATRICE DR ,  BACH ALFRED DR ,  UNGER LILIANE DR ,  TESCHENDORF HANS-JUERGEN DR ME ,  WICKE CARSTEN DR

IPC: C07D233/84 ,  A61K31/33 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4425 ,  A61K31/445 ,  A61K31/495 ,  A61K31/496 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  C07D213/56 ,  C07D213/64 ,  C07D213/65 ,  C07D213/70 ,  C07D213/73 ,  C07D213/79 ,  C07D213/81 ,  C07D233/90 ,  C07D307/79 ,  C07D333/24 ,  C07D333/28 ,  C07D333/38 ,  C07D471/18 ,  A61K31/52

Abstract: The present invention relates to the use of heterocyclic compounds of formula (I) Het - A - B - Ar in which Het A, B and Ar have the meanings given in the description. The compounds of the invention have a high affinity for the dopamine-D3-receptor and are therefore usable for the treatment of diseases responding to dopamine-D3-ligands.

公开(公告)号：DE4425144A1

公开(公告)日：1996-01-18

申请号：DE4425144

申请日：1994-07-15

Applicant: BASF AG

Inventor： HELLENDAHL BEATE DR ,  LANSKY ANNEGRET DR ,  MUNSCHAUER RAINER DR ,  BIALOJAN SIEGFRIED DR ,  UNGER LILIANE DR ,  TESCHENDORF HANS-JUERGEN DR ME ,  WICKE CARSTEN DR ,  DRESCHER KARLA DR

IPC: C07D249/08 ,  A61K31/41 ,  A61K31/435 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/505 ,  A61K31/53 ,  A61P1/08 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  C07D249/12 ,  C07D249/14 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14

Abstract: The present invention relates to triazole compounds of formula (I) in which R , R stand for H or different substituents, A stands for a bivalent group, B stands for a rest of the formula (a), (b) or (c) and Ar stands for optionally substituted phenyl, pyridyl, pyrimidyl or triazinyl. The compounds of the invention have a high affinity for the dopamine-D3-receptor and are therefore usable for the treatment of diseases responding to dopamine-D3-ligands.

公开(公告)号：DK0684226T3

公开(公告)日：1998-06-02

申请号：DK95112356

申请日：1992-01-24

Applicant: BASF AG

Inventor： SAUTER HUBERT DR ,  HARREUS ALBRECHT DR ,  LORENZ GISELA DR ,  AMMERMANN EBERHARD DR ,  GRAMMENOS WASSILIOS DR ,  HELLENDAHL BEATE DR ,  DUETZER REINHARDT DR

IPC: A01N37/50 ,  A01N43/54 ,  A01N43/58 ,  A01N43/76 ,  A01N43/836 ,  C07C69/65 ,  C07C69/653 ,  C07C69/734 ,  C07C69/738 ,  C07C251/48 ,  C07C251/50 ,  C07C251/52 ,  C07C251/54 ,  C07C251/56 ,  C07C251/58 ,  C07C251/60 ,  C07C251/86 ,  C07C255/15 ,  C07C255/57 ,  C07C255/58 ,  C07C255/62 ,  C07D213/77 ,  C07D239/42 ,  C07D241/20 ,  C07D263/32 ,  C07D333/28

Abstract: Iminoalkyl-phenylacrylic acid derivs. (I) ar new: R = H or 1-6C alkyl; R = H; 1-4C alkyl opt. substd. by halo; or opt. substd. aryl; Z ,Z = H; halo; CN; NO2;etc.;Y = O; NH; or NR ; and R = H; 1-4C alkoxycarbonyl-1-4C alkyl; or opt. substd. alkyl, cycloalkyl, etc.; or Y+R form a ring which is opt. substd. when Y = NH or NR ; R = 1-6C alkyl; X = CH-1-4C alkoxy or CH-1-4C alkylthio (also 1-4C alkylidene and 1-4C alkoxyimino in the description).

公开(公告)号：DE59308455D1

公开(公告)日：1998-05-28

申请号：DE59308455

申请日：1993-07-31

Applicant: BASF AG

Inventor： WINGERT HORST DR ,  HELLENDAHL BEATE DR ,  KIRSTGEN REINHARD DR ,  SAUTER HUBERT DR ,  AMMERMANN EBERHARD DR ,  LORENZ GISELA DR

IPC: A01N37/42 ,  A01N37/10 ,  A01N37/34 ,  A01N37/36 ,  A01N37/50 ,  A01N43/10 ,  A01N43/40 ,  A01N43/78 ,  A01N43/80 ,  A01N43/84 ,  A01N55/00 ,  C07C69/618 ,  C07C69/734 ,  C07C69/738 ,  C07C69/76 ,  C07C205/56 ,  C07C233/31 ,  C07C233/54 ,  C07C251/48 ,  C07C255/23 ,  C07C255/62 ,  C07C323/57 ,  C07C323/60 ,  C07D213/54 ,  C07D213/55 ,  C07D213/56 ,  C07D215/12 ,  C07D217/16 ,  C07D231/12 ,  C07D233/92 ,  C07D261/08 ,  C07D271/10 ,  C07D271/107 ,  C07D277/20 ,  C07D277/22 ,  C07D277/58 ,  C07D277/66 ,  C07D285/12 ,  C07D307/54 ,  C07D307/71 ,  C07D317/60 ,  C07D319/18 ,  C07D333/24 ,  C07D333/28 ,  C07D333/38 ,  C07D333/42 ,  C07D413/12 ,  C07D521/00 ,  C07F7/10 ,  C07F7/22

Abstract: Acetylene derivatives of the general formula I in which U, V and W denote hydrogen, halogen, nitro, cyano, alkyl and alkoxy, A denotes alkylidene, alkoxymethylidene, alkylthiomethylidene and alkoximino, B denotes OH, alkoxy and alkylamino and R denotes hydrogen, halogen, cyano, CF3, alkyl, cycloalkyl, haloalkyl, aryl, alkenyl, alkinyl, heterocyclyl, heteroaryl, arylalkyl, arylalkenyl, arylethinyl, heteroaryl-C1-C4-alkyl, C1-C4-alkoxy-C1-C4-alkyl, aryloxyalkyl, heteroaryloxyalkyl, arylamino-alkyl, arylthiomethyl, heteroarylthiomethyl, C(O)R , C(O)NR R , C(S)NR R , C(O)SR , C(S)OR , C(S)SR , CH(OH)R )R , SiR R R , SnR R R , C(OR)R , C(=N-OR )R , and the radicals R -R , R and R denote hydrogen, alkyl, aryl, heteroaryl, arylalkyl and heteroarylalkyl, and fungicides containing these compounds.

公开(公告)号：AT155775T

公开(公告)日：1997-08-15

申请号：AT95112355

申请日：1992-01-24

Applicant: BASF AG

Inventor： GRAMMENOS WASSILIOS DR ,  HARREUS ALBRECHT DR ,  SAUTER HUBERT DR ,  HELLENDAHL BEATE DR ,  DOETZER REINHARD DR ,  AMMERMANN EBERHARD DR ,  LORENZ GISELA DR

IPC: A01N37/50 ,  A01N43/54 ,  A01N43/58 ,  A01N43/76 ,  A01N43/836 ,  C07C69/65 ,  C07C69/653 ,  C07C69/734 ,  C07C69/738 ,  C07C251/48 ,  C07C251/50 ,  C07C251/52 ,  C07C251/54 ,  C07C251/56 ,  C07C251/58 ,  C07C251/60 ,  C07C251/86 ,  C07C255/15 ,  C07C255/57 ,  C07C255/58 ,  C07C255/62 ,  C07D213/77 ,  C07D239/42 ,  C07D241/20 ,  C07D263/32 ,  C07D333/28

Abstract: Iminoalkyl-phenylacrylic acid derivs. (I) ar new: R = H or 1-6C alkyl; R = H; 1-4C alkyl opt. substd. by halo; or opt. substd. aryl; Z ,Z = H; halo; CN; NO2;etc.;Y = O; NH; or NR ; and R = H; 1-4C alkoxycarbonyl-1-4C alkyl; or opt. substd. alkyl, cycloalkyl, etc.; or Y+R form a ring which is opt. substd. when Y = NH or NR ; R = 1-6C alkyl; X = CH-1-4C alkoxy or CH-1-4C alkylthio (also 1-4C alkylidene and 1-4C alkoxyimino in the description).

公开(公告)号：DE4425145A1

公开(公告)日：1996-01-18

申请号：DE4425145

申请日：1994-07-15

Applicant: BASF AG

Inventor： HELLENDAHL BEATE DR ,  LANSKY ANNEGRET DR ,  RENDENBACH-MUELLER BEATRICE DR ,  BACH ALFRED DR ,  UNGER LILIANE DR ,  TESCHENDORF HANS-JUERGEN DR ME ,  WICKE CARSTEN DR

IPC: C07D277/22 ,  A61K31/425 ,  A61K31/426 ,  A61K31/433 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/454 ,  A61K31/496 ,  A61K31/54 ,  C07D277/20 ,  C07D277/32 ,  C07D277/36 ,  C07D277/42 ,  C07D285/12 ,  C07D285/125 ,  C07D285/135 ,  C07D417/12 ,  A61K31/495 ,  C07D401/14

Abstract: The use is disclosed of thiazole and thiadiazole compounds having the formula (I), in which R , A, B and Ar have the meanings given in the description. These compounds have a high affinity to the dopamine D3 receptor and are therefore useful for treating diseases of the central nervous system.

公开(公告)号：DE4216941A1

公开(公告)日：1993-11-25

申请号：DE4216941

申请日：1992-05-22

Applicant: BASF AG

Inventor： HELLENDAHL BEATE DR ,  ROEHL FRANZ DR ,  RASCHACK MANFRED DR ,  HAFNER MATTHIAS DR

IPC: C07C211/49 ,  C07C215/50 ,  C07C217/58 ,  C07C219/28 ,  C07C233/43 ,  C07D521/00 ,  A61K31/135

Abstract: Para-substitued benzyl amines of general formula (I) in which W is a carbonyl group or a single bond, R is a lower alkyl group, R is an alkyl radical with 5 to 20 carbon atoms which may be branched and contain 1 to 3 double bonds, in addition a saturated cycle of 3 to 7 carbon atoms may be integrated into the chain or included as substituents, and may be substitued by one or more aromatic rings and contain a sulphur or oxygen atom, X is a group of the general formula: OR or NR R in which R stands for a lower alkyl, lower alkyl carbonyl, lower alkoxycarbonyl, mono lower alkyl aminocarbonyl, di lower alkyl aminocarbonyl group or a hydrogen atom, R is a lower alkyl group or a hydrogen atom and R is a hydrogen atom, a lower alkyl, lower alkyl carbonyl, lower alkoxy carbonyl, aminocarbonyl, mono lower alkyl aminocarbonyl or di lower alkyl aminocarbonyl group, Y is a hydrogen atom or a methyl group, and addition salts with physiologically acceptable acids and medicaments containing them.