公开(公告)号：DE4036782A1

公开(公告)日：1992-05-21

申请号：DE4036782

申请日：1990-11-17

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  PHILIPSBORN GERDA VON DR MED ,  SCHULT SABINE DR ,  KIRCHENGAST MICHAEL DR

IPC: A61K31/165 ,  A61K31/00 ,  A61K31/16 ,  A61K31/167 ,  A61K31/40 ,  A61K31/445 ,  A61K31/4453 ,  A61P9/00 ,  A61P9/06 ,  C07C233/29 ,  C07C235/38 ,  C07D295/08 ,  C07D295/088 ,  C07D295/092

Abstract: Substituted anilides of the formula I I (where R1 is C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, halogen, cyano, nitro, C2-C4-alkenyl, C2-C4-alkynyl; X is methylene, ethylene, vinylene; R2 and R3 are each C1-C4-alkyl, C3-C6-cycloalkyl or together are tetra- or pentamethylene; R4 is C1-C4-alkyl, methoxy; n is 2, 3 or 4), and the physiologically tolerated acid addition salts thereof, the pharmaceutical use thereof, drugs produced therefrom and the use thereof for treating cardiac arrhythmias and/or for lowering the heart rate, are described.

公开(公告)号：DE59204456D1

公开(公告)日：1996-01-11

申请号：DE59204456

申请日：1992-02-29

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  SCHULT SABINE DR ,  BEHL BERTHOLD DR ,  KIRCHENGAST MICHAEL DR

IPC: A61K31/445 ,  A61K31/4427 ,  A61K31/4465 ,  A61K31/4468 ,  A61K31/451 ,  A61K31/495 ,  A61K31/496 ,  A61P9/06 ,  C07D211/26 ,  C07D211/56 ,  C07D211/58 ,  C07D401/04 ,  C07D401/06

公开(公告)号：DE4117904A1

公开(公告)日：1992-12-03

申请号：DE4117904

申请日：1991-05-31

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  SCHULT SABINE DR ,  BEHL BERTHOLD DR ,  KIRCHENGAST MICHAEL DR

IPC: C07D211/26 ,  C07D211/56 ,  C07D211/58 ,  C07D401/04

Abstract: Substituted N-phenylpiperidines I (* CHEMICAL STRUCTURE *) I (R1=H, NO2, CN, halogen, C1-C4-alkyl, CF3, OCF3, OH, CH2OH, COOH, CHO, NH-CHO, NH2, CO-NH2, 5-tetrazinyl, R4-O-, R4-O-CH2-, R4O-CO-, R4-CO-, R4-NH-CO, R4-CO-NH-, R4-SO2-NH-; R2=H, NO2, halogen, C1-C4-alkyl or R4-O-; (* CHEMICAL STRUCTURE *) (* CHEMICAL STRUCTURE *) (* CHEMICAL STRUCTURE *) (* CHEMICAL STRUCTURE *) (* CHEMICAL STRUCTURE *) R4=C1-C4-alkyl or phenyl which can carry one of the R2 radicals; R5, R6=H or one of the R4 radicals; R7 =one of the R1 radicals; n=0 or 1; m=1 or 2; with the proviso that R3 is (* CHEMICAL STRUCTURE *) only when n is 1, and the optical isomers in the case of optical isomerism, and the physiologically tolerated acid addition salts, are suitable as drugs.

公开(公告)号：AT130851T

公开(公告)日：1995-12-15

申请号：AT92103514

申请日：1992-02-29

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  SCHULT SABINE DR ,  BEHL BERTHOLD DR ,  KIRCHENGAST MICHAEL DR

IPC: A61K31/445 ,  A61K31/4427 ,  A61K31/4465 ,  A61K31/4468 ,  A61K31/451 ,  A61K31/495 ,  A61K31/496 ,  A61P9/06 ,  C07D211/26 ,  C07D211/56 ,  C07D211/58 ,  C07D401/04 ,  C07D401/06 ,  C07D211/00 ,  C07D215/00

公开(公告)号：DE59107342D1

公开(公告)日：1996-03-14

申请号：DE59107342

申请日：1991-11-07

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  VON PHILIPSBORN GERDA DR ,  SCHULT SABINE DR ,  KIRCHENGAST MICHAEL DR

IPC: A61K31/165 ,  A61K31/00 ,  A61K31/16 ,  A61K31/167 ,  A61K31/40 ,  A61K31/445 ,  A61K31/4453 ,  A61P9/00 ,  A61P9/06 ,  C07C233/29 ,  C07C235/38 ,  C07D295/08 ,  C07D295/088 ,  C07D295/092

Abstract: Substituted anilides of the formula I I (where R1 is C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, halogen, cyano, nitro, C2-C4-alkenyl, C2-C4-alkynyl; X is methylene, ethylene, vinylene; R2 and R3 are each C1-C4-alkyl, C3-C6-cycloalkyl or together are tetra- or pentamethylene; R4 is C1-C4-alkyl, methoxy; n is 2, 3 or 4), and the physiologically tolerated acid addition salts thereof, the pharmaceutical use thereof, drugs produced therefrom and the use thereof for treating cardiac arrhythmias and/or for lowering the heart rate, are described.

公开(公告)号：AT133668T

公开(公告)日：1996-02-15

申请号：AT91118954

申请日：1991-11-07

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  VON PHILIPSBORN GERDA DR ,  SCHULT SABINE DR ,  KIRCHENGAST MICHAEL DR

IPC: A61K31/165 ,  A61K31/00 ,  A61K31/16 ,  A61K31/167 ,  A61K31/40 ,  A61K31/445 ,  A61K31/4453 ,  A61P9/00 ,  A61P9/06 ,  C07C233/29 ,  C07C235/38 ,  C07D295/08 ,  C07D295/088 ,  C07D295/092

Abstract: Substituted anilides of the formula I I (where R1 is C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, halogen, cyano, nitro, C2-C4-alkenyl, C2-C4-alkynyl; X is methylene, ethylene, vinylene; R2 and R3 are each C1-C4-alkyl, C3-C6-cycloalkyl or together are tetra- or pentamethylene; R4 is C1-C4-alkyl, methoxy; n is 2, 3 or 4), and the physiologically tolerated acid addition salts thereof, the pharmaceutical use thereof, drugs produced therefrom and the use thereof for treating cardiac arrhythmias and/or for lowering the heart rate, are described.

公开(公告)号：DE4114330A1

公开(公告)日：1992-11-05

申请号：DE4114330

申请日：1991-05-02

Applicant: BASF AG

Inventor： KIRCHENGAST MICHAEL DR ,  RUEBSAMEN KLAUS DR ,  SCHMIED BERNHARD DR ,  SEITZ WERNER DR

IPC: A61K31/275 ,  A61K45/06

Abstract: The description relates to combinations of medicaments of calcium/serotonin antagonists and thromboxane-A2-receptors suitable for treating diseases.