公开(公告)号：CZ245797A3

公开(公告)日：1998-06-17

申请号：CZ245797

申请日：1996-02-12

Applicant: BASF AG

Inventor： BOHM HANS-JOACHIM DR ,  HOFFKEN HANS WOLFGANG DR ,  HORNBERGER WILFRIED DR ,  KOSER STEFAN DR ,  MACK HELMUT DR ,  PFEIFFER THOMAS DR ,  SEITZ WERNER DR ,  ZIERKE THOMAS DR

IPC: A61K31/00 ,  A61K38/55 ,  A61P7/02 ,  C07D205/04 ,  C07D207/16 ,  C07D213/53 ,  C07D213/63 ,  C07D213/72 ,  C07D213/78 ,  C07D213/79 ,  C07D239/28 ,  C07D241/14 ,  C07D241/24 ,  C07D401/12 ,  C07K5/06 ,  C07K5/062 ,  C07K5/078 ,  A61K31/40 ,  A61K31/445 ,  A61K31/495

Abstract: The invention relates to a compound of the formula I: or a salt thereof with a physiologically tolerated acid, or stereoisomers thereof, wherein R 1 , R 2 , A, B, C and D have the meanings described in the specification.

公开(公告)号：CZ9702376A3

公开(公告)日：1998-04-15

申请号：CZ237697

申请日：1996-02-06

Applicant: BASF AG

Inventor： SEITZ WERNER DR ,  MACK HELMUT DR ,  ZIERKE THOMAS DR ,  BOHM HANS-JOACHIM DR ,  HOFFKEN HANS WOLFGANG DR ,  KOSER STEFAN DR ,  PFEIFFER THOMAS DR ,  HORNBERGER WILFRIED DR

IPC: A61K38/55 ,  A61K38/00 ,  A61P7/02 ,  C07K5/06 ,  C07K5/065 ,  C07K5/072 ,  C07K5/087

CPC classification number: C07K5/0812 ,  A61K38/00 ,  C07K5/06026 ,  C07K5/06034 ,  C07K5/0606 ,  C07K5/06078 ,  C07K5/06113 ,  C07K5/06191

公开(公告)号：CZ237697A3

公开(公告)日：1998-04-15

申请号：CZ237697

申请日：1996-02-06

Applicant: BASF AG

Inventor： SEITZ WERNER DR ,  MACK HELMUT DR ,  ZIERKE THOMAS DR ,  BOHM HANS-JOACHIM DR ,  HOFFKEN HANS WOLFGANG DR ,  KOSER STEFAN DR ,  PFEIFFER THOMAS DR ,  HORNBERGER WILFRIED DR

IPC: A61K38/55 ,  A61K38/00 ,  A61P7/02 ,  C07K5/06 ,  C07K5/065 ,  C07K5/072 ,  C07K5/087

Abstract: PCT No. PCT/EP96/00472 Sec. 371 Date Jul. 30, 1997 Sec. 102(e) Date Jul. 30, 1997 PCT Filed Feb. 6, 1996 PCT Pub. No. WO96/24609 PCT Pub. Date Aug. 15, 1996Thrombin inhibitors of the formula where R1, A, B and D have the meaning indicated in the description, and intermediates for the preparation thereof are described. The compounds I are suitable for controlling diseases.

公开(公告)号：DE3785225D1

公开(公告)日：1993-05-13

申请号：DE3785225

申请日：1987-01-24

Applicant: BASF AG

Inventor： UNGER LILIANE DR ,  RASCHACK MANFRED DR ,  BALDINGER VERENA DR ,  DENGEL FERDINAND DR ,  EHRMANN OSKAR DR ,  TREIBER HANS JOERG DR ,  SEITZ WERNER DR

IPC: A61K31/275 ,  A61K31/335 ,  A61K31/357 ,  A61P7/02 ,  A61P9/00 ,  A61P9/12 ,  A61P43/00 ,  C07C67/00 ,  C07C253/00 ,  C07C255/32 ,  C07C255/42 ,  C07C255/43 ,  C07C255/53 ,  C07C255/58 ,  C07D317/58 ,  C07D319/08 ,  C07D319/18 ,  C07D321/12 ,  C07D325/00

Abstract: Phenylacetonitrile derivs. of formula (I), their antipodes and salts with physiologically acceptable acids are new. R1 and R2 = H, halo, 1-3C alkyl, NO2, MeO, EtO, CF3O or CF3CH2O; R3 and R4 = H, halo, CF3, 1-3C alkyl, NO2, MeO or EtO; R5 = H, halo or 1-3C alkyl; or R3 and R5 are together methylenedioxy; ethylenedioxy; 1,3-dioxatetramethylene; propylene or butylene; at least one of R1-R5 is other than H, and when R6 = isopropyl, R7 = Me, m = 3, n = 2 and p = zero, then R1-R4 cannot simultaneously be MeO or EtO; R6 = up to 6C, satd. or unsatd. hydrocarbyl; 3-8C cycloalkyl; 5-8C cycloalkenyl or R3, R4, R5-substd. phenyl; R7 = 1-4C alkyl; m = 2-4. n = 2-3; p = 0 or 1.

公开(公告)号：DE3781116D1

公开(公告)日：1992-09-17

申请号：DE3781116

申请日：1987-10-21

Applicant: BASF AG

Inventor： SEITZ WERNER DR ,  DAUM LOTHAR DR ,  EMLING FRANZ DR ,  KEILHAUER GERHARD DR

IPC: A61K31/275 ,  A61K31/277 ,  A61P35/00

Abstract: (+)-Verapamil, (+)-gallopamil, (+)-devapamil and/or (+)-emopamil can be used to protect against tumour metastases.

公开(公告)号：DE3826796A1

公开(公告)日：1990-02-08

申请号：DE3826796

申请日：1988-08-06

Applicant: BASF AG

Inventor： KEILHAUER GERHARD DR ,  KOENIG HORST PROF DR ,  SCHLICK ERICH DR ,  SEITZ WERNER DR

IPC: A61K31/275 ,  A61K31/277 ,  A61P3/00 ,  A61P3/14 ,  A61P35/00 ,  C07C255/42 ,  C07C255/43

Abstract: Use of substituted phenylacetonitriles of formula (I) to overcome resistance to cancerostatic drugs.

公开(公告)号：DE3642331A1

公开(公告)日：1988-06-23

申请号：DE3642331

申请日：1986-12-11

Applicant: BASF AG

Inventor： SEITZ WERNER DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR ,  BALDINGER VERENA DR ,  RUEBSAMEN KLAUS DR ,  GRIES JOSEF DR

IPC: A61K31/275 ,  A61K31/335 ,  A61K31/357 ,  A61K31/36 ,  A61P1/04 ,  A61P3/00 ,  A61P9/00 ,  A61P11/00 ,  A61P43/00 ,  C07C67/00 ,  C07C253/00 ,  C07C253/30 ,  C07C255/32 ,  C07C255/33 ,  C07C255/35 ,  C07C255/37 ,  C07C255/42 ,  C07C255/53 ,  C07C255/58 ,  C07D317/50 ,  C07D317/60 ,  C07D319/08 ,  C07D319/18 ,  C07D321/00 ,  C07C121/75 ,  C07C121/66

Abstract: Basic-substituted phenylacetonitriles of the formula I … … in which… R to R and n have the meaning given in the description, are suitable for combating diseases.

公开(公告)号：DE3344755A1

公开(公告)日：1985-06-20

申请号：DE3344755

申请日：1983-12-10

Applicant: BASF AG

Inventor： RASCHACK MANFRED DR ,  KREISKOTT HORST PROF DR ,  SEITZ WERNER DR

IPC: C07B57/00 ,  A61K20060101 ,  A61K31/275 ,  A61P9/00 ,  C07B31/00 ,  C07C20060101 ,  C07C67/00 ,  C07C253/00 ,  C07C255/32 ,  C07C255/42 ,  C07C255/58 ,  C07D20060101 ,  C07C121/66

Abstract: 1,7-diphenyl-3-methylaza-7-cyano-8-methylnonane and its antipodes and salts are used for the treatment of diseases.

公开(公告)号：CZ153797A3

公开(公告)日：1998-02-18

申请号：CZ153797

申请日：1995-11-25

Applicant: BASF AG

Inventor： BOHM HANS JOACHIM DR ,  KOSER STEFAN DR ,  MACK HELMUT DR ,  PFEIFFER THOMAS DR ,  SEITZ WERNER DR ,  HOFFKEN HANS WOLFGANG DR ,  HORNBERGER WILFRIED DR ,  ZIERKE THOMAS DR

IPC: A61K38/00 ,  A61K38/05 ,  A61K38/55 ,  A61P7/02 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065 ,  C07K5/072 ,  C07K5/087

公开(公告)号：DE19630082A1

公开(公告)日：1998-01-29

申请号：DE19630082

申请日：1996-07-26

Applicant: BASF AG

Inventor： MACK HELMUT DR ,  PFEIFFER THOMAS DR ,  SEITZ WERNER DR ,  ZIERKE THOMAS DR ,  BALKENHOHL FRIEDHELM DR ,  LANGE UDO DR

IPC: C12P17/04 ,  C07D207/22 ,  C07D401/12 ,  C07D401/04 ,  C07B57/00

Abstract: A process is disclosed for preparing 3-pyrroline-2-carboxylic acid derivatives of formula (I), in which R stands for H, C1-C6-alkyl, benzyl, benzyl substituted at the phenyl radical, allyloxycarbonyl, C1-C6-alkyloxycarbonyl, benzyloxycarbonyl, in which the benzyl radical can be substituted by OCH3 radicals, or for C1-C4-alkylcarbonyl; or R stands for an amino acid radical which can be alkylated or acylated at the nitrogen and is linked by the C-terminal; and R stands for OH, C1-C4-alkyloxy, benzyloxy or an N R group, in which R and R represent independently from each other H, C1-C4-alkyl, benzyl, phenyl or pyridyl, in which the aromatic compounds in R and R can be substituted by up to three identical or different substituents selected from the group composed of methyl, methoxy, hydroxy, cyano or halogen. According to this process, the sulphonic acid radical is eliminated by means of a base from a compound having the formula (II), in which R and R have the above meanings and R stands for C1-C6-alkyl, benzyl, trifluoromethyl, naphthyl or phenyl optionally substituted by radicals from the group composed of methyl, nitro and halogen.