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公开(公告)号：HU9900574A2
公开(公告)日：1999-06-28
申请号：HU9900574
申请日：1997-02-11
Applicant: BASF AG
Inventor： BOLLSCHWEILER CLAUS , FRIEDRICH THOMAS , HOEFFKEN HANS WOLFGANG , RADITSCH MARTIN , RUEBSAMEN KLAUS , SCHMIDT MARTIN , SCHWEDEN JUERGEN
IPC: C12N15/09 , A61K31/00 , A61K38/00 , A61K38/46 , A61P7/00 , A61P7/04 , C07K14/47 , C12N9/74 , C12N15/00 , C12N15/57 , C12R1/91 , A61K38/48
Abstract: PCT No. PCT/EP97/00612 Sec. 371 Date Aug. 4, 1998 Sec. 102(e) Date Aug. 4, 1998 PCT Filed Feb. 11, 1997 PCT Pub. No. WO97/29198 PCT Pub. Date Aug. 14, 1997The invention concerns thrombin muteins which have the following differences in their sequences as compared with natural thrombin: (a) the exchange of a Gly after Ala, the Gly being in the sequence environment Tyr-Gly-Phe and having position 558 in natural human thrombin (SEQ ID No. 14); (b) at least one exchange or deletion of the following radicals: (b1) His, located in the sequence environment Ala-His-Cys and having position 363 in natural human thrombin (SEQ ID No. 14); (b2) Asp, located in the sequence environment Arg-Asp-Ile and having position 419 in natural human thrombin (SEQ ID No. 14); (b3) Ser, located in the sequence environment Asp-Ser-Gly and having position 525 in natural human thrombin (SEQ ID No. 14). The invention further concerns the use of these muteins as antidotes.
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2.发明专利
公开(公告)号：ZA8709280B
公开(公告)日：1989-08-30
申请号：ZA8709280
申请日：1987-12-10
Applicant: BASF AG
Inventor： SEITZ WERNER , WERNER SEITZ , UNGER LILIANE , LILIANE UNGER , RASCHACK MANFRED , MANFRED RASCHACK , BALDINGER VERENA , VERENA BALDINGER , RUEBSAMEN KLAUS , KLAUS RUEBSAMEN , GRIES JOSEF , JOSEF GRIES
IPC: A61K31/275 , A61K31/335 , A61K31/357 , A61K31/36 , A61P1/04 , A61P3/00 , A61P9/00 , A61P11/00 , A61P43/00 , C07C67/00 , C07C253/00 , C07C253/30 , C07C255/32 , C07C255/35 , C07C255/42 , C07C255/53 , C07C255/58 , C07D317/50 , C07D317/60 , C07D319/08 , C07D319/18 , C07D321/00 , C07C , A61K , C07D
CPC classification number: C07C255/00 , C07D317/60 , C07D319/08
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公开(公告)号：AU587661B2
公开(公告)日：1989-08-24
申请号：AU6610086
申请日：1986-12-04
Applicant: BASF AG
Inventor： SEITZ WERNER , BALDINGER VERENA , GRIES JOSEF , LENKE DIETER , RASCHACK MANFRED , RUEBSAMEN KLAUS
IPC: A61K31/135 , A61P1/04 , A61P9/00 , A61P9/12 , C07C223/02 , C07D317/58 , C07D319/18 , C07D325/00 , C07C95/08 , C07D319/08
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公开(公告)号：DK61789A
公开(公告)日：1989-08-14
申请号：DK61789
申请日：1989-02-10
Applicant: BASF AG
Inventor： ESCHENFELDER VOLKER , SCHMIED BERNHARD , RUEBSAMEN KLAUS
Abstract: The mixture is suitable for controlling thrombotic vascular disorders.
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5.发明专利
公开(公告)号：AU8240387A
公开(公告)日：1988-06-16
申请号：AU8240387
申请日：1987-12-10
Applicant: BASF AG
Inventor： SEITZ WERNER , UNGER LILIANE , RASCHACK MANFRED , BALDINGER VERENA , RUEBSAMEN KLAUS , GRIES JOSEF
IPC: A61K31/275 , A61K31/335 , A61K31/357 , A61K31/36 , A61P1/04 , A61P3/00 , A61P9/00 , A61P11/00 , A61P43/00 , C07C67/00 , C07C253/00 , C07C253/30 , C07C255/32 , C07C255/33 , C07C255/35 , C07C255/37 , C07C255/42 , C07C255/53 , C07C255/58 , C07D317/50 , C07D317/60 , C07D319/08 , C07D319/18 , C07D321/00 , C07C121/80 , C07C121/78
Abstract: Basic-substituted phenylacetonitriles of the formula I … … in which… R to R and n have the meaning given in the description, are suitable for combating diseases.
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Patent Agency Ranking
公开(公告)号：AU6610086A
公开(公告)日：1987-06-11
申请号：AU6610086
申请日：1986-12-04
Applicant: BASF AG
Inventor： SEITZ WERNER , BALDINGER VERENA , GRIES JOSEF , LENKE DIETER , RASCHAK MANFRED , RUEBSAMEN KLAUS
IPC: A61K31/135 , A61P1/04 , A61P9/00 , A61P9/12 , C07C223/02 , C07D317/58 , C07D319/18 , C07D325/00 , C07C95/08 , C07D319/08
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公开(公告)号：NO852793L
公开(公告)日：1986-01-13
申请号：NO852793
申请日：1985-07-11
Applicant: BASF AG
Inventor： GEISS KARL-HEINZ , SCHMIED BERNHARD , RASCHACK MANFRED , LEHMANN HANS-DIETER , GRIES JOSEF , RUEBSAMEN KLAUS
IPC: A61K31/50 , A61K31/55 , A61P1/04 , A61P7/02 , A61P9/04 , A61P9/12 , C07D237/00 , C07D403/04 , C07D403/10 , C07D
Abstract: Novel pyrrol-1-ylphenyldihydropyridazinones of the formula I their preparation and their use in the treatment of disorders.
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公开(公告)号：ZA9701107B
公开(公告)日：1998-08-11
申请号：ZA9701107
申请日：1997-02-11
Applicant: BASF AG
Inventor： RADITSCH MARTIN , FRIEDRICH THOMAS , BOLLSCHWEILER CLAUS , SCHMIDT MARTIN , HOEFFKEN HANS WOLFGANG , SCHWEDEN JUERGEN , RUEBSAMEN KLAUS
IPC: C12N15/09 , A61K31/00 , A61K38/00 , A61K38/46 , A61P7/00 , A61P7/04 , C07K14/47 , C12N9/74 , C12N15/00 , C12N15/57 , C12R1/91 , C07K , A61K , C07H
CPC classification number: C12N9/6429 , A61K38/00 , C12Y304/21005
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公开(公告)号：CA2245546A1
公开(公告)日：1997-08-14
申请号：CA2245546
申请日：1997-02-11
Applicant: BASF AG
Inventor： H FFKEN HANS WOLFGANG , SCHWEDEN JUERGEN , RADITSCH MARTIN , FRIEDRICH THOMAS , RUEBSAMEN KLAUS , SCHMIDT MARTIN , BOLLSCHWEILER CLAUS
IPC: C12N15/09 , A61K31/00 , A61K38/00 , A61K38/46 , A61P7/00 , A61P7/04 , C07K14/47 , C12N9/74 , C12N15/00 , C12N15/57 , C12R1/91 , A61K38/48
Abstract: The invention concerns thrombin muteins which have the following differences in their sequences as compared with natural thrombin: (a) the exchange of a Gly after Ala, the Gly being in the sequence environment Tyr-Gly-Phe and having position 558 in natural human thrombin (SEQ ID No. 14); (b) at least one exchange or deletion of the following radicals: (b1) His, located in the sequence environment Ala-His-Cys and having position 363 in natural human thrombin (SEQ ID No. 14); (b2) Asp, located in the sequence environment ArgAsp-Ile and having position 419 in natural human thrombin (SEQ ID No. 14); (b3) Ser, located in the sequence environment Asp-Ser-Gly and having position 525 in natural human thrombin (SEQ ID No. 14). The invention further concerns the use of these muteins as antidotes.
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公开(公告)号：LV5809A4
公开(公告)日：1997-02-20
申请号：LV960306
申请日：1996-07-22
Applicant: BASF AG
Inventor： KURFUERST MANFRED , RUEBSAMEN KLAUS , SCHMIED BERNHARD , KOERWER WOLFGANG , SCHWEDEN JUERGEN , HOEFFKEN HANS W
IPC: A61K38/58 , A61K47/48 , C07K14/815 , C07K17/08
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