公开(公告)号：AT34741T

公开(公告)日：1988-06-15

申请号：AT84100381

申请日：1984-01-16

Applicant: BASF AG

Inventor： ROSSY PHILLIP A DR ,  THYES MARCO DR ,  FRANKE ALBRECHT DR ,  KOENIG HORST PROF DR ,  LEHMANN HANS DIETER PROF DR ,  GRIES JOSEF DR ,  FRIEDRICH LUDWIG DR ,  LENKE DIETER PROF DR

IPC: A61K31/50 ,  A61K31/502 ,  A61K31/535 ,  A61K31/55 ,  A61P1/04 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04 ,  C07D237/14 ,  C07D237/26 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D417/14 ,  C07D521/00

公开(公告)号：DE3146599A1

公开(公告)日：1983-07-07

申请号：DE3146599

申请日：1981-11-25

Applicant: BASF AG

Inventor： SCHLECKER RAINER DIPL CHEM DR ,  FRIEDRICH LUDWIG DR ,  LENKE DIETER PROF DR

IPC: A61K31/505 ,  A61P37/08 ,  C07D239/95 ,  C07D487/04 ,  C07D491/04 ,  C07D491/14 ,  C07D491/147

Abstract: 1,2,4-Triazolo[1,5-c]-quinazolinones of the general formula I (I) and their pharmaceutically tolerated salts, processes for their preparation and pharmaceutical formulations which contain these compounds and are useful drugs in the treatment of allergic disorders.

公开(公告)号：DE3112164A1

公开(公告)日：1982-10-14

申请号：DE3112164

申请日：1981-03-27

Applicant: BASF AG

Inventor： SCHLECKER RAINER DIPL CHEM DR ,  FRANKE ALBRECHT DIPL CHEM DR ,  HAGEN HELMUT DIPL ING DR ,  FRIEDRICH LUDWIG DR ,  LENKE DIETER PROF DR

IPC: C07D275/04 ,  A61K31/425

Abstract: The present invention relates to benzisothiazolyloxamide esters and the acids on which they are based and their salts, processes for their preparation and pharmaceutical preparations containing these compounds, which preparations can be used as medicaments in the treatment of allergic disorders.

公开(公告)号：DE3101502A1

公开(公告)日：1982-08-26

申请号：DE3101502

申请日：1981-01-19

Applicant: BASF AG

Inventor： THIEME PETER C DR ,  STEINER GERD DR ,  ROHR WOLFGANG DR ,  LENKE DIETER PROF DR ,  GRIES JOSEF DR MED ,  WEIFENBACH HARALD DR ,  TESCHENDORF HANS-JUERGEN DR ME ,  HOFMANN HANS PETER DR ,  KREISKOTT HORST DR

IPC: C07D249/08 ,  A61K31/41 ,  A61K31/415 ,  A61K31/495 ,  A61K31/496 ,  A61P9/02 ,  A61P11/00 ,  A61P25/20 ,  C07D231/12 ,  C07D233/60 ,  C07D233/61 ,  C07D271/10 ,  C07D295/06 ,  C07D295/067 ,  C07D295/096 ,  C07D521/00 ,  C07D403/12 ,  C07D413/12

Abstract: Novel phenylpiperazinylpropane and -butane derivatives of hetarylphenols and hetarylanilines of the formula where R1 is hydrogen or alkyl of 1 to 4 carbon atoms, R2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms or alkoxy where alkyl is of 1 to 3 carbon atoms, the phenyl ring can be monosubstituted or disubstituted by R2, X is oxygen or an NH group, and the heterocyclic structure Het. is 1,3,4-oxadiazolyl, triazolyl, imidazolyl or pyrazolyl, and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and exhibit predominantly sedative, neuroleptic and hypotensive properties.

公开(公告)号：DE2944222A1

公开(公告)日：1981-05-14

申请号：DE2944222

申请日：1979-11-02

Applicant: BASF AG

Inventor： FRICKEL FRITZ-FRIEDER DIPL CHE ,  FRANKE ALBRECHT DIPL CHEM DR ,  HAGEN HELMUT DIPL ING DR ,  LENKE DIETER PROF DR ,  GRIES JOSEF DR MED

IPC: C07D275/04 ,  A61K31/425

Abstract: Novel amino-derivs. of 1,2-benzisothiazole are of formula (I). n is 2 or 3; R1 and R2 are H or opt. branched 1-5C alkyl; R3 is Ph, opt. mono-, di- or tri-substd. by halogen, alkyl, alkoxy, alkylthio, haloalkyl or haloalkoxy (these 2 gps. contg. 1-3 halogen), hydroxyalkyl or alkoxyalkyl (all alkyl gps. contg. 1-5C), 2-6C alkenyl, alkinyl or alkinyloxy, 3-8 ring C cycloalkoxy, methylene dioxy, amino, 1-5C alkylamino or di(1-5C)alkylamino. R3 may also be indanyl or tetrabydropaphthyl). The physiologically acceptable acid addn.-salts of (I) are also new. (I) are pharmaceuticals and can be used in heart and circulatory disorders. As a result of their beta-sympatholytic action, (I) are esp. suitable for the treatment of coronary heart disease, hypertonia and disturbances of cardiac rhythm. Suitable unit doese for humans are 1-100 (sp. 3-50) mg. (I) are strong beta-sympatholytics of low toxicity and have a therapeutic breadth 3-12 times greater than that of the known beta-sympatholitic propandol.

公开(公告)号：DE2846567A1

公开(公告)日：1980-05-08

申请号：DE2846567

申请日：1978-10-26

Applicant: BASF AG

Inventor： TREIBER HANS JOERG DR ,  LENKE DIETER PROF DR ,  WORSTMANN WOLFGANG DR MED

IPC: A61K31/55 ,  A61K31/553 ,  A61P25/04 ,  C07D267/00 ,  C07D267/12 ,  C07D267/14

Abstract: PCT No. PCT/EP79/00080 Sec. 371 Date Jun. 26, 1980 Sec. 102(e) Date Jun. 16, 1980 PCT Filed Oct. 22, 1979 PCT Pub. No. WO80/00838 PCT Pub. Date May 1, 1980. The invention relates to novel 1,4-cycloalkano-oxazepines of the general formula where R1 is hydrogen, hydroxyl or alkoxy or acyloxy of 1 to 4 carbon atoms, R2 is a hydrocarbon radical of 1 to 3 carbon atoms, n is 1, 2 or 3 and x is 0 or 1, and of its salts with physiologically acceptable acids; processes for their preparation, and their use in therapy. The novel substances are suitable for the pharmacotherapy of pains of various origins.

公开(公告)号：DE2704794A1

公开(公告)日：1978-08-17

申请号：DE2704794

申请日：1977-02-05

Applicant: BASF AG

Inventor： FRICKEL FRITZ-FRIEDER DIPL CHE ,  HAGEN HELMUT DIPL ING DR ,  OHNSORGE ULRICH DIPL CHEM DR ,  FRANKE ALBRECHT DIPL CHEM DR ,  LENKE DIETER PROF DR ,  GRIES JOSEF DR MED ,  LEHMANN HANS DIETER DR MED

IPC: A61K31/428 ,  C07D275/04 ,  A61K31/425

Abstract: New aminopropanol derivatives of 4-hydroxy-1,2-benzisothiazole and their addition salts with acids, their preparation, and pharmaceutical formulations which contain the said compounds and may be used for the treatment and prophylaxis of cardiac and circulatory disorders.

公开(公告)号：DE3665861D1

公开(公告)日：1989-11-02

申请号：DE3665861

申请日：1986-11-26

Applicant: BASF AG

Inventor： SEITZ WERNER DR ,  BALDINGER VERENA DR ,  GRIES JOSEF DR ,  LENKE DIETER PROF DR ,  RASCHACK MANFRED DR ,  RUEBSAMEN KLAUS DR

IPC: A61K31/135 ,  A61P1/04 ,  A61P9/00 ,  A61P9/12 ,  C07C223/02 ,  C07D317/58 ,  C07D319/18 ,  C07D325/00 ,  C07C95/08

公开(公告)号：AT33020T

公开(公告)日：1988-04-15

申请号：AT85115389

申请日：1985-12-04

Applicant: BASF AG

Inventor： FRANKE ALBRECHT DR ,  MUELLER CLAUS D DR ,  LENKE DIETER PROF DR

IPC: A61K31/135 ,  A61K31/13 ,  A61K31/445 ,  A61K31/535 ,  A61K31/5375 ,  A61P9/06 ,  C07C67/00 ,  C07C213/00 ,  C07C215/38 ,  C07C217/08 ,  C07D295/08 ,  C07D295/084 ,  C07C91/23 ,  C07C89/02 ,  C07C93/04

公开(公告)号：DE3460024D1

公开(公告)日：1986-03-06

申请号：DE3460024

申请日：1984-03-10

Applicant: BASF AG

Inventor： FRANKE ALBRECHT DR ,  GRIES JOSEF DR ,  MUELLER CLAUS D DR ,  LENKE DIETER PROF DR

IPC: C07D211/52 ,  A61K31/13 ,  A61K31/445 ,  A61K31/451 ,  A61P9/06 ,  C07C67/00 ,  C07C213/00 ,  C07C217/32 ,  C07C313/00 ,  C07C323/25 ,  C07D211/44 ,  C07D295/08 ,  C07D295/092 ,  C07D303/22 ,  C07C93/06

Abstract: Compounds of the general formula I where R1, R2, R3, R4 and n have the meanings given in the description, are useful for treating cardiac disorders.