公开(公告)号：DK0759901T3

公开(公告)日：1999-12-13

申请号：DK95920008

申请日：1995-05-09

Applicant: BASF AG

Inventor： M LLER STEFAN ,  KARL ULRICH ,  DE POTZOLLI BERND

IPC: C07B61/00 ,  C07C227/18 ,  C07C229/12 ,  C07C269/06 ,  C07C271/22 ,  C07C323/59

Abstract: A process for preparing N-protected N-alkylated amino acids of the formula I:in which the substituents have the meanings stated in the description, comprises mixing a compound of the formula IIwith a solution of potassium tert-butanolate in a non-protic organic solvent, and subsequently adding a C1-2-alkyl halide.

公开(公告)号：DK0758342T3

公开(公告)日：2000-05-01

申请号：DK95917963

申请日：1995-04-26

Applicant: BASF AG

Inventor： BUSCHMANN ERNST ,  HAUPT ANDREAS ,  JANSSEN BERND ,  AMBERG WILHELM ,  BERNARD HARALD ,  JANITSCHKE LOTHAR ,  KARL ULRICH ,  KLING ANDREAS ,  M LLER STEFAN ,  DE POTZOLLI BERND ,  RITTER KURT ,  THYES MARCO ,  ZIERKE THOMAS

IPC: A61K38/08 ,  A61K38/00 ,  A61P35/00 ,  C07K1/08 ,  C07K5/10 ,  C07K5/103 ,  C07K7/06 ,  C07K14/52

Abstract: PCT No. PCT/EP95/01577 Sec. 371 Date Nov. 4, 1996 Sec. 102(e) Date Nov. 4, 1996 PCT Filed Apr. 26, 1995 PCT Pub. No. WO95/30691 PCT Pub. Date Nov. 16, 1995The compound Me2Val-Val-MeVal-Pro-Pro-NHBzlxHCl is described. It is prepared from Z-Val-Val-MeVal-Pro-OR1 where Z and R1 have the meanings stated in the description. The compound shows antineoplastic activity.