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公开(公告)号：DE3936594A1
公开(公告)日：1991-03-28
申请号：DE3936594
申请日：1989-11-03
Applicant: BASF AG
IPC: A61K31/715 , A61K38/45 , A61K38/46 , A61K38/54 , A61P7/02 , A61P9/08 , A61P9/10 , A61P35/00 , C12N9/10
Abstract: The description relates to the use of gamma glutamyl transferases in the treatment of diseases.
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公开(公告)号：DE4403665A1
公开(公告)日：1995-08-10
申请号：DE4403665
申请日：1994-02-07
Applicant: BASF AG
Inventor： KROEGER BURKHARD DR , SEULBERGER HARALD DR , SUBKOWSKI THOMAS DR , HILLEN HEINZ DR , JACOB ELARD DR , MEYER THOMAS DR , OTTER RAINER DR , SCHMIDT MARTIN DR
Abstract: An endothelin converting enzyme (ECE) having the 754 (bovine) or 753 (human) amino acid sequence shown in the specification, or functional fragments, is new. Also claimed is DNA defined as (a) coding for the ECE as above, (b) having the 2314 (bovine) or 2720 (human) nucleotide sequence given in the specification or complementary sequences, or (c) encoding proteins which are recognised by antibodies generated against ECE as above.
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公开(公告)号：DE3939801A1
公开(公告)日：1991-06-06
申请号：DE3939801
申请日：1989-12-01
Applicant: BASF AG
Inventor： MEYER THOMAS DR , FRIEDRICH THOMAS DR , KOERWER WOLFGANG DR , STRUBE KARL-HERMANN DR , BIALOJAN SIEGFRIED DR
Abstract: Described is a protein which dissolves blood clots, prepared fromthe leech Hirudo Medicinalis, containing the sequences 1-13 listed in the sequence protocoland capable of splitting epsilon -( alpha -glutamyl)-lysine compounds, plus its muteins and natural variants with a comparable action.
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公开(公告)号：DE3823519A1
公开(公告)日：1990-01-18
申请号：DE3823519
申请日：1988-07-12
Applicant: BASF AG
Inventor： MEYER THOMAS DR
IPC: C12N9/64
Abstract: A process for the purification of activated protein C and analogous proteins by affinity chromatography is described.
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公开(公告)号：CZ9601394A3
公开(公告)日：1997-10-15
申请号：CZ139496
申请日：1994-11-10
Applicant: BASF AG
Inventor： KROGER BURKHARD DR , SEULBERGER HARALD DR , MEYER THOMAS DR , SCHMIDT MARTIN DR , JACOB ELARD DR , OTTER RAINER DR , SUBKOWSKI THOMAS DR , HILLEN HEINZ DR
IPC: G01N33/573 , A61K31/70 , A61K35/12 , A61K38/00 , A61K38/43 , A61K39/395 , A61K48/00 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/04 , A61P25/28 , A61P29/00 , A61P31/04 , C07H21/04 , C07K14/47 , C12N5/00 , C12N5/10 , C12N9/64 , C12N15/09 , C12N15/57 , C12R1/91 , A01K67/027 , A61K38/48 , C07K16/40 , C12N15/11
CPC classification number: C12N9/6497 , A61K38/00 , C12Y304/24071
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Patent Agency Ranking
公开(公告)号：DE4234921A1
公开(公告)日：1994-04-21
申请号：DE4234921
申请日：1992-10-16
Applicant: BASF AG
IPC: A61K38/00 , C07K14/815 , C07K15/08 , A61K37/02
Abstract: Described is a new anticoagulant protein from land leeches of the genus Haemadipsa, having the N-terminal amino acid sequence: A-Val-Lys-Phe-Cys-Gly-His-Pro-Leu-Ser-Leu-Pro-Thr-Ala-Leu-Cys-Ala, where A represents an indefinite amino acid. This protein can be used in combatting diseases.
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公开(公告)号：DE3823804A1
公开(公告)日：1990-01-18
申请号：DE3823804
申请日：1988-07-14
Applicant: BASF AG
Inventor： MOELLER ACHIM DR , EMLING FRANZ DR , KURFUERST MANFRED DR , MEYER THOMAS DR
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公开(公告)号：CZ139496A3
公开(公告)日：1997-10-15
申请号：CZ139496
申请日：1994-11-10
Applicant: BASF AG
Inventor： KROGER BURKHARD DR , SEULBERGER HARALD DR , MEYER THOMAS DR , SCHMIDT MARTIN DR , JACOB ELARD DR , OTTER RAINER DR , SUBKOWSKI THOMAS DR , HILLEN HEINZ DR
IPC: G01N33/573 , A01K67/027 , A61K31/70 , A61K35/12 , A61K38/00 , A61K38/43 , A61K38/48 , A61K39/395 , A61K48/00 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/04 , A61P25/28 , A61P29/00 , A61P31/04 , C07H21/04 , C07K14/47 , C07K16/40 , C12N5/00 , C12N5/10 , C12N9/64 , C12N15/09 , C12N15/113 , C12N15/57 , C12R1/91 , C12N15/11
Abstract: PCT No. PCT/EP94/03706 Sec. 371 Date May 16, 1996 Sec. 102(e) Date May 16, 1996 PCT Filed Nov. 10, 1994 PCT Pub. No. WO95/14095 PCT Pub. Date May 26, 1995The invention relates to endothelin-converting enzymes containing the polypeptide sequence described in SEQ. ID. NO. 30 or SEQ. ID. NO. 36 or functional fragments thereof, genes which code for such enzymes, and processes for producing the said enzymes and the use thereof.
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公开(公告)号：DE4412372A1
公开(公告)日：1995-10-19
申请号：DE4412372
申请日：1994-04-12
Applicant: BASF AG
Inventor： KROEGER BURKHARD DR , SEULBERGER HARALD DR , SUBKOWSKI THOMAS DR , HILLEN HEINZ DR , JACOB ELARD DR , MEYER THOMAS DR , OTTER RAINER DR , SCHMIDT MARTIN DR
Abstract: An endothelin converting enzyme (ECE) having the 754 (bovine) or 753 (human) amino acid sequence shown in the specification, or functional fragments, is new. Also claimed is DNA defined as (a) coding for the ECE as above, (b) having the 2314 (bovine) or 2720 (human) nucleotide sequence given in the specification or complementary sequences, or (c) encoding proteins which are recognised by antibodies generated against ECE as above.
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公开(公告)号：DE4339100A1
公开(公告)日：1995-05-18
申请号：DE4339100
申请日：1993-11-16
Applicant: BASF AG
Inventor： KROEGER BURKHARD DR , SEULBERGER HARALD DR , MEYER THOMAS DR , SCHMIDT MARTIN DR , JACOB ELARD DR , OTTER RAINER DR , SUBKOWSKI THOMAS DR , HILLEN HEINZ DR
Abstract: Endothelin converting enzyme (ECE) having mol.wt. 250000 Da and a partial amino acid sequence with at least 80% homology to sequence (I) is new: Xaa-Xaa-Pro-Asn-Ala-Leu-Asn-Phe-Gly-Gly-Ile-Gly-Val-Val-Val-Gly-His-Gl u-Leu-Thr-His-Ala-Phe- (I) Also claimed is a method for the isolation of ECE by (i) stimulation of mammalian cells for overproduction of ECE with an inhibitor of ECE, and (ii) isolation of the ECE. The pref. cell line is a bovine cell line FBHE and the pref. inhibitor is phosphoramidon (PHAM).
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