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公开(公告)号：CZ290684B6
公开(公告)日：2002-09-11
申请号：CZ287396
申请日：1995-03-23
Applicant: BASF AG
Inventor： BAUMANN ERNST DR , VOGELBACHER UWE JOSEF DR , RHEINHEIMER JOACHIM DR , KLINGE DAGMAR DR , RIECHERS HARTMUT DR , KROGER BURKHARD DR , BIALOJAN SIEGFRIED DR , BOLLSCHWEILER CLAUS DR , WERNER VOLFGANG DR , UNGER LILIANE DR , RASCHACK MANFRED DR
IPC: C07D251/26 , A61K31/00 , A61K31/505 , A61K31/506 , A61K31/53 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/04 , A61P39/02 , C07D239/26 , C07D239/34 , C07D239/38 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
Abstract: The present invention relates to the use of carboxylic acid derivatives of the general formula I for preparing medicament i.e. endothelin receptor antagonists. The medicament can be used for treating hypertension, renal insufficiency, and restenosis after angioplasty.
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公开(公告)号：DE4425144A1
公开(公告)日：1996-01-18
申请号：DE4425144
申请日：1994-07-15
Applicant: BASF AG
Inventor： HELLENDAHL BEATE DR , LANSKY ANNEGRET DR , MUNSCHAUER RAINER DR , BIALOJAN SIEGFRIED DR , UNGER LILIANE DR , TESCHENDORF HANS-JUERGEN DR ME , WICKE CARSTEN DR , DRESCHER KARLA DR
IPC: C07D249/08 , A61K31/41 , A61K31/435 , A61K31/4427 , A61K31/445 , A61K31/505 , A61K31/53 , A61P1/08 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , C07D249/12 , C07D249/14 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
Abstract: The present invention relates to triazole compounds of formula (I) in which R , R stand for H or different substituents, A stands for a bivalent group, B stands for a rest of the formula (a), (b) or (c) and Ar stands for optionally substituted phenyl, pyridyl, pyrimidyl or triazinyl. The compounds of the invention have a high affinity for the dopamine-D3-receptor and are therefore usable for the treatment of diseases responding to dopamine-D3-ligands.
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公开(公告)号：DE4400748A1
公开(公告)日：1995-07-20
申请号：DE4400748
申请日：1994-01-13
Applicant: BASF AG
Inventor： SEULBERGER HARALD DR , STERRER SYLVIA DR , BIALOJAN SIEGFRIED DR
IPC: C12Q1/68 , C12Q1/6897 , C12Q1/37 , C12Q1/66
Abstract: Substances (I) that influence expression of renin (II) are identified by (1) transfecting a host cell with a recombinant vector that contains the regulatory region of the (II) gene functionally coupled to a reporter gene (RG); (2) either (a) isolating cells that carry the vector transiently or (b) generating cell lines that have stably integrated the vector; (3) exposing these cells to test cpds., and (4) measuring expression of RG.
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公开(公告)号：DE3821757A1
公开(公告)日：1990-02-08
申请号：DE3821757
申请日：1988-06-28
Applicant: BASF AG
Inventor： MUELLER-NEUMANN MARKUS DR , SCHMIDT MARTIN DR , SCHWARZ MARGARETE DR , BALDINGER VERENA DR , DOERPER THOMAS DR , BOELLSCHWEILER CLAUS DR , STRUBE KARL-HERMANN DR , BIALOJAN SIEGFRIED DR
Abstract: Polypeptides of the formula A-tPA1-111-X-tPA112-527, in which A, tPA1-111, X and tPA112-527 have the meaning indicated in the description, and their preparation are described. The polypeptides are suitable for controlling diseases.
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公开(公告)号：DE4433479A1
公开(公告)日：1996-03-21
申请号：DE4433479
申请日：1994-09-20
Applicant: BASF AG
Inventor： FRIEDRICH THOMAS DR , BIALOJAN SIEGFRIED DR
IPC: A61K38/00 , C07K7/08 , C07K14/81 , C12Q1/56 , A61K35/64 , C07K1/12 , C07K1/14 , C12N9/74 , C12N9/99
Abstract: Proteins (I and II) having the (N-terminal) sequences below are new: VYGGCGGNDNNYESE; and SYGGCGGNENNEETI.
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Patent Agency Ranking
公开(公告)号：DE4408690A1
公开(公告)日：1995-09-21
申请号：DE4408690
申请日：1994-03-15
Applicant: BASF AG
Inventor： KROEGER BURKHARD DR , BIALOJAN SIEGFRIED DR , BOLLSCHWEILER CLAUS DR
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公开(公告)号：DE4400745A1
公开(公告)日：1995-07-20
申请号：DE4400745
申请日：1994-01-13
Applicant: BASF AG
Inventor： KROEGER BURKHARD DR , BIALOJAN SIEGFRIED DR
IPC: C07K14/75 , C12Q1/66 , C12Q1/68 , C12Q1/6897
Abstract: Substances (I) that inhibit expression of beta-fibrinogen (II) are identified by (1) transfecting a host cell with a recombinant vector that contains the regulatory region of the (II) gene functionally coupled to a reporter gene (RG); (2) either (a) isolating cells that carry the vector transiently or (b) generating cell lines that have stably integrated the vector; (3) exposing these cells to test cpds. and (4) measuring expression of RG.
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公开(公告)号：DE4234921A1
公开(公告)日：1994-04-21
申请号：DE4234921
申请日：1992-10-16
Applicant: BASF AG
IPC: A61K38/00 , C07K14/815 , C07K15/08 , A61K37/02
Abstract: Described is a new anticoagulant protein from land leeches of the genus Haemadipsa, having the N-terminal amino acid sequence: A-Val-Lys-Phe-Cys-Gly-His-Pro-Leu-Ser-Leu-Pro-Thr-Ala-Leu-Cys-Ala, where A represents an indefinite amino acid. This protein can be used in combatting diseases.
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公开(公告)号：DE4136513A1
公开(公告)日：1993-05-13
申请号：DE4136513
申请日：1991-11-06
Applicant: BASF AG
IPC: A61K35/64 , A61K38/00 , A61K38/55 , A61P7/02 , C07K14/00 , C07K14/245 , C07K14/435 , C07K14/81 , C12N15/15 , C12P21/02 , C12R1/19
Abstract: The description relates to a novel thrombin inhibiting protein from reduvii with a molecular weight of some 12000 Dalton and the N-terminus Glu-Gly-Gly-Glu-Pro-Cys-Ala-Cys-Pro-His-Ala-Leu-His-Arg-Val-Cys-Gly-Se r-Asp. The protein is useful in combatting diseases.
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公开(公告)号：DE4134814A1
公开(公告)日：1993-04-29
申请号：DE4134814
申请日：1991-10-22
Applicant: BASF AG
Inventor： FRIEDRICH THOMAS DR , BIALOJAN SIEGFRIED DR , BOLLSCHWEILER CLAUS DR , KUENAST CHRISTOPH DR
IPC: A61K35/64 , A61K38/00 , A61K38/55 , A61P7/02 , C07K14/435 , C07K14/81 , C12N15/09 , C12N15/15 , C12P21/02 , C12R1/19
Abstract: Described is a new thrombin-inhibiting protein isolated from ticks, with a molecular weight of about 8000 Daltons and the N-terminus Leu-Asn-Val-Leu-Cys-Asn-Asn-Pro-His-Thr-Ala-Asp-Cys-Asn-Asn-Asp-Ala-Gl n-Val-Asp. The protein is suitable for use in the treatment of illnesses.
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