公开(公告)号：DE3735916A1

公开(公告)日：1989-05-03

申请号：DE3735916

申请日：1987-10-23

Applicant: BASF AG

Inventor： KOERWER WOLFGANG DR ,  KURFUERST MANFRED DR ,  BALDINGER VERENA DR ,  DOERPER THOMAS DR

IPC: A61K38/46 ,  A61P7/02 ,  C07K1/22 ,  C07K14/00 ,  C12N9/72 ,  C12N15/00 ,  C12N15/09 ,  C12R1/19 ,  C12R1/91

公开(公告)号：AT69953T

公开(公告)日：1991-12-15

申请号：AT88120960

申请日：1988-12-15

Applicant: BASF AG

Inventor： HERR DIETER DR ,  DOERPER THOMAS DR ,  DAUM LOTHAR DR ,  GEISS KARL-HEINZ DR ,  MOELLER ACHIM DR

IPC: C08B37/10 ,  A61K20060101 ,  A61K31/715 ,  A61P31/12 ,  A61K31/725

公开(公告)号：DE3744119A1

公开(公告)日：1989-07-06

申请号：DE3744119

申请日：1987-12-24

Applicant: BASF AG

Inventor： HERR DIETER DR ,  DOERPER THOMAS DR ,  DAUM LOTHAR DR ,  GEISS KARL-HEINZ DR ,  MOELLER ACHIM DR

IPC: C08B37/10 ,  A61K20060101 ,  A61K31/715 ,  A61P31/12

公开(公告)号：DE3620656A1

公开(公告)日：1987-12-23

申请号：DE3620656

申请日：1986-06-20

Applicant: BASF AG

Inventor： SCHOLLMEIER KLAUS DR ,  MOELLER ACHIM DR ,  KOERWER WOLFGANG DR ,  DOERPER THOMAS DR

IPC: C07K14/52 ,  A61K38/00 ,  A61P35/00 ,  C07K14/00 ,  C07K14/525 ,  C12N15/00 ,  C12N15/09 ,  C12P21/02 ,  C12R1/19 ,  C12N1/20 ,  A61K37/02 ,  A61K45/05 ,  C07K15/04 ,  C07K15/12 ,  C12P19/34 ,  C12P21/00

公开(公告)号：ES2052513T3

公开(公告)日：1994-07-16

申请号：ES87108847

申请日：1987-06-20

Applicant: BASF AG

Inventor： SCHOLLMEIER KLAUS DR ,  MOELLER ACHIM DR ,  KOERWER WOLFGANG DR ,  DOERPER THOMAS DR ,  HILLEN HEINZ DR ,  DAUM LOTHAR DR ,  EMLING FRANZ DR ,  KEILHAUER GERHARD DR

IPC: C07K14/52 ,  A61K38/00 ,  A61P35/00 ,  C07K14/00 ,  C07K14/525 ,  C12N15/00 ,  C12N15/09 ,  C12P21/02 ,  C12R1/19 ,  A61K37/02 ,  C07K15/00

公开(公告)号：DE3866686D1

公开(公告)日：1992-01-16

申请号：DE3866686

申请日：1988-12-15

Applicant: BASF AG

Inventor： HERR DIETER DR ,  DOERPER THOMAS DR ,  DAUM LOTHAR DR ,  GEISS KARL-HEINZ DR ,  MOELLER ACHIM DR

IPC: C08B37/10 ,  A61K20060101 ,  A61K31/715 ,  A61P31/12 ,  A61K31/725

Abstract: Polysulphated heparins (I) are used to prepare medicaments for prophylaxis and therapy of diseases caused by retroviruses. (I) have an S content of 13-15% and a molecular wt. of 2000-20,000 (esp. 2000-9000 for oral admin). They may be prepd. by converting heparin to the pyridinium salt and reacting this with ClSO3H in pyridine. The medicaments may be formulated for oral or parenteral admin., or as sprays. The daily dose is 10-1000 mg/kg oral or 0.1-10 mg/kg parenteral.

公开(公告)号：DE3925183A1

公开(公告)日：1991-02-07

申请号：DE3925183

申请日：1989-07-29

Applicant: BASF AG

Inventor： DOERPER THOMAS DR ,  HILLEN HEINZ DR ,  EMLING FRANZ DR ,  DAUM LOTHAR DR ,  MOELLER ACHIM DR

IPC: A61K38/00 ,  A61P29/00 ,  A61P31/04 ,  A61P37/06 ,  C07K14/47 ,  C07K14/52 ,  C07K14/525 ,  C07K19/00 ,  C12N1/21 ,  C12N5/24 ,  C12N15/09 ,  C12P21/02 ,  C12R1/19

Abstract: The invention relates to derivatives of the tumour necrosis factor (TNF) produced by joining partial sequences of the heavy leukokinine chain to the terminal amino of the mature human TNF. These proteins are suitable for use in drugs. A process for obtaining them is also described.

公开(公告)号：AT82329T

公开(公告)日：1992-11-15

申请号：AT87108847

申请日：1987-06-20

Applicant: BASF AG

Inventor： SCHOLLMEIER KLAUS DR ,  MOELLER ACHIM DR ,  KOERWER WOLFGANG DR ,  DOERPER THOMAS DR ,  HILLEN HEINZ DR ,  DAUM LOTHAR DR ,  EMLING FRANZ DR ,  KEILHAUER GERHARD DR

IPC: C07K14/52 ,  A61K38/00 ,  A61P35/00 ,  C07K14/00 ,  C07K14/525 ,  C12N15/00 ,  C12N15/09 ,  C12P21/02 ,  C12R1/19 ,  A61K37/02 ,  C07K15/00

公开(公告)号：DE3821757A1

公开(公告)日：1990-02-08

申请号：DE3821757

申请日：1988-06-28

Applicant: BASF AG

Inventor： MUELLER-NEUMANN MARKUS DR ,  SCHMIDT MARTIN DR ,  SCHWARZ MARGARETE DR ,  BALDINGER VERENA DR ,  DOERPER THOMAS DR ,  BOELLSCHWEILER CLAUS DR ,  STRUBE KARL-HERMANN DR ,  BIALOJAN SIEGFRIED DR

IPC: A61K38/00 ,  C12N9/72

Abstract: Polypeptides of the formula A-tPA1-111-X-tPA112-527, in which A, tPA1-111, X and tPA112-527 have the meaning indicated in the description, and their preparation are described. The polypeptides are suitable for controlling diseases.

公开(公告)号：DE3815886A1

公开(公告)日：1989-11-09

申请号：DE3815886

申请日：1988-05-10

Applicant: BASF AG

Inventor： MUELLER-NEUMANN MARKUS DR ,  SCHMIDT MARTIN DR ,  BALDINGER VERENA DR ,  DOERPER THOMAS DR ,  BOLLSCHWEILER CLAUS DR

IPC: A61K38/00 ,  C12N9/72

Abstract: Polypeptides of the formula A-tPA1-111-X-tPA112-527, in which A, tPA1-111, X and tPA112-527 have the meaning stated in the description, and the preparation thereof are described. The polypeptides are suitable for controlling diseases.