公开(公告)号：DE3620656A1

公开(公告)日：1987-12-23

申请号：DE3620656

申请日：1986-06-20

Applicant: BASF AG

Inventor： SCHOLLMEIER KLAUS DR ,  MOELLER ACHIM DR ,  KOERWER WOLFGANG DR ,  DOERPER THOMAS DR

IPC: C07K14/52 ,  A61K38/00 ,  A61P35/00 ,  C07K14/00 ,  C07K14/525 ,  C12N15/00 ,  C12N15/09 ,  C12P21/02 ,  C12R1/19 ,  C12N1/20 ,  A61K37/02 ,  A61K45/05 ,  C07K15/04 ,  C07K15/12 ,  C12P19/34 ,  C12P21/00

公开(公告)号：AT82329T

公开(公告)日：1992-11-15

申请号：AT87108847

申请日：1987-06-20

Applicant: BASF AG

Inventor： SCHOLLMEIER KLAUS DR ,  MOELLER ACHIM DR ,  KOERWER WOLFGANG DR ,  DOERPER THOMAS DR ,  HILLEN HEINZ DR ,  DAUM LOTHAR DR ,  EMLING FRANZ DR ,  KEILHAUER GERHARD DR

IPC: C07K14/52 ,  A61K38/00 ,  A61P35/00 ,  C07K14/00 ,  C07K14/525 ,  C12N15/00 ,  C12N15/09 ,  C12P21/02 ,  C12R1/19 ,  A61K37/02 ,  C07K15/00

公开(公告)号：DE3782549D1

公开(公告)日：1992-12-17

申请号：DE3782549

申请日：1987-06-20

Applicant: BASF AG

Inventor： SCHOLLMEIER KLAUS DR ,  MOELLER ACHIM DR ,  KOERWER WOLFGANG DR ,  DOERPER THOMAS DR ,  HILLEN HEINZ DR ,  DAUM LOTHAR DR ,  EMLING FRANZ DR ,  KEILHAUER GERHARD DR

IPC: C07K14/52 ,  A61K38/00 ,  A61P35/00 ,  C07K14/00 ,  C07K14/525 ,  C12N15/00 ,  C12N15/09 ,  C12P21/02 ,  C12R1/19 ,  A61K37/02 ,  C07K15/00

Abstract: (I) and their allelic variations and mutagenically produced derivs. with lymphotoxin or lymphotoxin-like activity, as well as derivs. having an N-terminal immunogenic peptide sequence, are new. (I) is X-Leu-Lys-Pro-Ala-Ala-His-Leu-Ile -Gly-Asp-Pro-Ser-Lys-Gln-Asn-Ser-Leu- Leu-Trp-Arg-Ala-Asn-Thr-Asp-Arg-Ala-Phe-Leu-Gln-Asp-Gly-Phe-Ser-L- eu-Ser-Asn-Asn-Ser-Leu-Leu -Val-Pro-Thr-Ser-Gly-Ile -Tyr-Phe-Val-Tyr-Ser-Gln- -Val-Val-Phe-Ser-Gly-Lys-Ala-Tyr-Ser-Pro-Lys-Ala-Thr- Ser-Ser-Pro-Leu Tyr-Leu-Ala-His-Glu-Val -Gln- Leu-Phe-Ser--Ser-Gln-Tyr-Pro-Phe-His-Val-Pro- Leu-Leu-Ser-Ser-Gln -Lys-Met-Val-Tyr-Pro-Gly- Leu-Gln-Glu-Pro -Trp-Leu-His-Ser-Met-Tyr-His-Gly -Ala-Ala-Phe-Gln-Leu-Thr-Gln-Gly-Asp- Gln-Leu-Ser-Thr -His-Thr-Asp-Gly-Ile-Pro-His-Leu -Val-Leu-Ser-Pro Ser-Thr-Val-Phe-Phe-Gly -Ala-Phe-Ala-Leu, where X = Thr, Ser-Thr, Met-Ser-Thr, Ala-Thr or Ala-Ser-Thr. DNA sequences coding for the polypeptides are also new.

公开(公告)号：DE3730331A1

公开(公告)日：1989-03-30

申请号：DE3730331

申请日：1987-09-10

Applicant: BASF AG

Inventor： KREIMEYER ANDREAS DR ,  DAUM LOTHAR DR ,  SCHOLLMEIER KLAUS DR

IPC: A61K38/00 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07K1/22 ,  C07K14/52 ,  C07K14/525 ,  C07K14/555 ,  C07K14/57 ,  C12N15/09 ,  C12P21/02 ,  C12R1/19

公开(公告)号：ES2052513T3

公开(公告)日：1994-07-16

申请号：ES87108847

申请日：1987-06-20

Applicant: BASF AG

Inventor： SCHOLLMEIER KLAUS DR ,  MOELLER ACHIM DR ,  KOERWER WOLFGANG DR ,  DOERPER THOMAS DR ,  HILLEN HEINZ DR ,  DAUM LOTHAR DR ,  EMLING FRANZ DR ,  KEILHAUER GERHARD DR

IPC: C07K14/52 ,  A61K38/00 ,  A61P35/00 ,  C07K14/00 ,  C07K14/525 ,  C12N15/00 ,  C12N15/09 ,  C12P21/02 ,  C12R1/19 ,  A61K37/02 ,  C07K15/00

公开(公告)号：DE3843534A1

公开(公告)日：1990-07-12

申请号：DE3843534

申请日：1988-12-23

Applicant: BASF AG

Inventor： DAUM LOTHAR DR ,  DOERPER THOAMS DR ,  HILLEN HEINZ DR ,  MOELLER ACHIM DR ,  SCHOLLMEIER KLAUS DR ,  WALKER NIGEL DR ,  KEILHAUER GERHARD DR

IPC: A61K38/00 ,  C07K14/525 ,  C12N1/21 ,  C12N15/28

Abstract: Polypeptides derived from tumour necrosis factors (TNF) differ from natural TNF by the substitution and/or deletion of amino acids. These novel polypeptides are useful therapeutic agents.