公开(公告)号：DE2860111D1

公开(公告)日：1980-11-27

申请号：DE2860111

申请日：1978-06-13

Applicant: BASF AG

Inventor： BINNIG FRITZ DR ,  FRIEDRICH LUDWIG DR ,  HOFMANN HANS PETER DR ,  KREISKOTT HORST DR ,  MUELLER CLAUS DR ,  RASCHACK MANFRED DR

IPC: A61K31/435 ,  A61K31/445 ,  A61P9/06 ,  C07D221/00 ,  C07D471/08

Abstract: Bispidine derivatives of the formula where R1 is H or C6H5, R2 is H, Cl or CF3, R3 is H, F or Cl and X is 0 or 1, and drugs which contain these compounds. The compounds are prepared by condensing N-monobenzylbispidine with appropriately substituted phenylethyl halides or by a Mannich reaction of N-benzylpiperid-4-one with appropriately substituted phenylalkylamines, followed by reduction. They exhibit mainly anti-arrhythmic action.