公开(公告)号：DE3886327D1

公开(公告)日：1994-01-27

申请号：DE3886327

申请日：1988-09-17

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  BINNIG FRITZ DR ,  VON PHILIPSBORN GERDA DR

IPC: A61K31/435 ,  A61K31/44 ,  A61P9/06 ,  C07D471/08

Abstract: Bispidine derivatives of the formula I I where R, R1 and R3 are identical or different and are each H, C1-C4-alkyl, halogen or C1-C4-alkoxy, when Y is R2 is C1-C4-alkyl, halogen, -CN, C1-C4-alkoxy, -NHSO2CH3, -CF3, NH-acetyl or -NR4R5 where R4 and R5 are each C1-C4-alkyl, when Y is R2 is C1-C4-alkyl, halogen, -CN1C1-C4-alkoxy, -NHSO2CH3, -CF3, NH-acetyl or -NR9R10 where R9 is C1-C4-alkyl and R10 is H or C1-C4-alkyl, and when X is not CH2 R2 may also be NO2 or NH2, X is -CH2-, -C(O)- or -C(R6)OR7- (where R6 is H or C1-C4-alkyl and R7 is H, C1-C4-alkyl or where R8 is H, C1-C4-alkyl, halogen or C1 -C4-alkoxy), Y is -C(O) or -CONH- and Z is C1-C4-alkylene which may be olefinically unsaturated and/or branched, and their physiologically tolerated salts, and drugs containing these compounds as active compounds are described.

公开(公告)号：DE3732094A1

公开(公告)日：1989-04-06

申请号：DE3732094

申请日：1987-09-24

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  BINNIG FRITZ DR ,  PHILIPSBORN GERDA VON DR MED

IPC: A61K31/435 ,  A61K31/44 ,  A61P9/06 ,  C07D471/08

Abstract: Bispidine derivatives of the formula I I where R, R1 and R3 are identical or different and are each H, C1-C4-alkyl, halogen or C1-C4-alkoxy, when Y is R2 is C1-C4-alkyl, halogen, -CN, C1-C4-alkoxy, -NHSO2CH3, -CF3, NH-acetyl or -NR4R5 where R4 and R5 are each C1-C4-alkyl, when Y is R2 is C1-C4-alkyl, halogen, -CN1C1-C4-alkoxy, -NHSO2CH3, -CF3, NH-acetyl or -NR9R10 where R9 is C1-C4-alkyl and R10 is H or C1-C4-alkyl, and when X is not CH2 R2 may also be NO2 or NH2, X is -CH2-, -C(O)- or -C(R6)OR7- (where R6 is H or C1-C4-alkyl and R7 is H, C1-C4-alkyl or where R8 is H, C1-C4-alkyl, halogen or C1 -C4-alkoxy), Y is -C(O) or -CONH- and Z is C1-C4-alkylene which may be olefinically unsaturated and/or branched, and their physiologically tolerated salts, and drugs containing these compounds as active compounds are described.

公开(公告)号：DE3260265D1

公开(公告)日：1984-07-26

申请号：DE3260265

申请日：1982-03-19

Applicant: BASF AG

Inventor： BINNIG FRITZ DR ,  MUELLER CLAUS D DR ,  RASCHACK MANFRED DR ,  VON PHILIPSBORN GERDA DR

IPC: A61K31/435 ,  A61K31/445 ,  A61P9/00 ,  A61P9/06 ,  C07D221/00 ,  C07D471/08

Abstract: Bispidine derivatives of the formula I I where R is hydrogen or amino, and their salts with physiologically tolerated acids. The compounds have antiarrhythmic properties.

公开(公告)号：GR75859B

公开(公告)日：1984-08-02

申请号：GR820167244

申请日：1982-02-08

Applicant: BASF AG

Inventor： BINNIG FRITZ DR ,  MUELLER CLAUS D DR ,  RASCHACK MANFRED DR

IPC: A61K31/435 ,  A61K31/445 ,  A61P9/00 ,  A61P9/06 ,  C07D221/00 ,  C07D471/08

Abstract: Bispidine derivatives of the formula I I where R is hydrogen or amino, and their salts with physiologically tolerated acids. The compounds have antiarrhythmic properties.

公开(公告)号：DE2860111D1

公开(公告)日：1980-11-27

申请号：DE2860111

申请日：1978-06-13

Applicant: BASF AG

Inventor： BINNIG FRITZ DR ,  FRIEDRICH LUDWIG DR ,  HOFMANN HANS PETER DR ,  KREISKOTT HORST DR ,  MUELLER CLAUS DR ,  RASCHACK MANFRED DR

IPC: A61K31/435 ,  A61K31/445 ,  A61P9/06 ,  C07D221/00 ,  C07D471/08

Abstract: Bispidine derivatives of the formula where R1 is H or C6H5, R2 is H, Cl or CF3, R3 is H, F or Cl and X is 0 or 1, and drugs which contain these compounds. The compounds are prepared by condensing N-monobenzylbispidine with appropriately substituted phenylethyl halides or by a Mannich reaction of N-benzylpiperid-4-one with appropriately substituted phenylalkylamines, followed by reduction. They exhibit mainly anti-arrhythmic action.