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1.发明公开
公开(公告)号：EP0944609A4
公开(公告)日：2000-03-08
申请号：EP97948371
申请日：1997-11-18
Inventor： ANNEN ULRICH , DELINE JAMES E , FOLAND LAFAYETTE D , KLOTTER KEVIN A , MUELLER JOSEF , MUELLER MICHAEL , MUENDINGER KLAUS , PHILLIPPI MARTIN A , RULAND ALFRED , SCHAEFER WOLFGANG , SCHUERMANN GREGOR , WIDDER RUDI , ZIELSKE ALFRED G
IPC: C07D295/14 , C07D265/12 , C07D291/00 , C07D295/15 , C11D3/39 , C07D211/26 , C07D211/34 , C07D295/12
CPC classification number: C07D295/15 , C11D3/3925
Abstract: A process for the preparation of a compound having the structure of Formula (I) wherein A, R1, R2, R3, Y and Z are as defined in the disclosure. The process includes reacting a heterocyclic amine with a monoaldehyde or a dialdehyde in a pH range of from about 8 to 14 and then quaternizing the so-reacted heterocyclic amine with an alkylating agent at a pH of not less than about 2. The use of a pH control substantially prevents formation of an undesirable protonated intermediate.
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公开(公告)号：MX9905076A
公开(公告)日：2000-04-30
申请号：MX9905076
申请日：1999-05-31
Inventor： ANNEN ULRICH , DELINE JAMES E , FOLAND LAFAYETTE D , KLOTTER KEVIN A , MUELLER JOSEF , MUELLER MICHAEL , MUENDINGER KLAUS , PHILLIPPI MARTIN A , RULAND ALFRED , SCHAEFER WOLFGANG , SCHUERMANN GREGOR , WIDDER RUDI , ZIELSKE ALFRED G
IPC: C07D295/14 , C07D265/12 , C07D291/00 , C07D295/15 , C11D3/39
Abstract: A process for the preparation of a compound having the structure of Formula (I) wherein A, R1, R2, R3, Y and Z are as defined in the disclosure. The process includes reacting a heterocyclic amine with a monoaldehyde or a dialdehyde in a pH range of from about 8 to 14 and then quaternizing the so-reacted heterocyclic amine with an alkylating agent at a pH of not less than about 2. The use of a pH control substantially prevents formation of an undesirable protonated intermediate.
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公开(公告)号：DK172610B1
公开(公告)日：1999-02-22
申请号：DK438388
申请日：1988-08-05
Applicant: BASF AG
Inventor： BIRNBACH STEFAN , MUELLER JOSEF , WULZ KLAUS , HOUBEN JOCHEN
Abstract: Etherified polyoxyalkylene derivatives of the formula where R1 is hydrogen, C1-C20-alkyl or C3-C5-alkenyl, R2 and R3 independently of one another are each hydrogen, methyl or ethyl, R4 is C1-C4-alkyl and m and n are identical or different and are each greater than or equal to 0, with the proviso that the sum of m and n is from 3 to 300, are prepared by reacting the corresponding hydroxyl-containing polyoxyalkylene derivative with a dialkyl sulfate in the presence of an alkali metal hydroxide by a process in which the reaction is carried out at from 20 DEG to 60 DEG C. in the presence of an aqueous solution of an alkali metal hydroxide, the concentration of alkali metal hydroxide during the entire duration of the reaction being not less than 35% by weight, based on the aqueous phase, and not less than 1 mole of dialkyl sulfate and not less than one mole of alkali metal hydroxide are used per mole equivalent of organic hydroxyl groups.
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公开(公告)号：DK164699B
公开(公告)日：1992-08-03
申请号：DK416082
申请日：1982-09-17
Applicant: BASF AG
Inventor： FRANKE ALBRECHT , MUELLER JOSEF , LIETZ HELMUT , WIERSDORFF WALTER-WIELANT , HEGE HANS-GUENTHER , MUELLER CLAUS D , GRIES JOSEF , LENKE DIETER , PHILIPSBORN GERDA VON , RASCHACK MANFRED
IPC: A61K31/13 , A61K31/445 , A61K31/495 , C07C45/62 , C07C45/71 , C07C45/73 , C07C45/74 , C07C49/83 , C07C49/835 , C07C49/84 , C07D211/46 , C07D211/52 , C07D295/08 , C07D295/092 , C07D303/22 , C07D303/24 , C07C217/36 , C07C323/25 , C07D207/08 , C07D211/14 , C07D295/088
Abstract: Novel aminopropanol derivatives of 2-hydroxy- beta -phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.
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公开(公告)号：NO883506L
公开(公告)日：1989-02-07
申请号：NO883506
申请日：1988-08-05
Applicant: BASF AG
Inventor： BIRNBACH STEFAN , MUELLER JOSEF , WULZ KLAUS , HOUBEN JOCHEN
Abstract: Etherified polyoxyalkylene derivatives of the formula where R1 is hydrogen, C1-C20-alkyl or C3-C5-alkenyl, R2 and R3 independently of one another are each hydrogen, methyl or ethyl, R4 is C1-C4-alkyl and m and n are identical or different and are each greater than or equal to 0, with the proviso that the sum of m and n is from 3 to 300, are prepared by reacting the corresponding hydroxyl-containing polyoxyalkylene derivative with a dialkyl sulfate in the presence of an alkali metal hydroxide by a process in which the reaction is carried out at from 20 DEG to 60 DEG C. in the presence of an aqueous solution of an alkali metal hydroxide, the concentration of alkali metal hydroxide during the entire duration of the reaction being not less than 35% by weight, based on the aqueous phase, and not less than 1 mole of dialkyl sulfate and not less than one mole of alkali metal hydroxide are used per mole equivalent of organic hydroxyl groups.
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Patent Agency Ranking
公开(公告)号：NO883506D0
公开(公告)日：1988-08-05
申请号：NO883506
申请日：1988-08-05
Applicant: BASF AG
Inventor： BIRNBACH STEFAN , MUELLER JOSEF , WULZ KLAUS , HOUBEN JOCHEN
Abstract: Etherified polyoxyalkylene derivatives of the formula where R1 is hydrogen, C1-C20-alkyl or C3-C5-alkenyl, R2 and R3 independently of one another are each hydrogen, methyl or ethyl, R4 is C1-C4-alkyl and m and n are identical or different and are each greater than or equal to 0, with the proviso that the sum of m and n is from 3 to 300, are prepared by reacting the corresponding hydroxyl-containing polyoxyalkylene derivative with a dialkyl sulfate in the presence of an alkali metal hydroxide by a process in which the reaction is carried out at from 20 DEG to 60 DEG C. in the presence of an aqueous solution of an alkali metal hydroxide, the concentration of alkali metal hydroxide during the entire duration of the reaction being not less than 35% by weight, based on the aqueous phase, and not less than 1 mole of dialkyl sulfate and not less than one mole of alkali metal hydroxide are used per mole equivalent of organic hydroxyl groups.
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公开(公告)号：CS236489B2
公开(公告)日：1985-05-15
申请号：CS666882
申请日：1982-09-16
Applicant: BASF AG
Inventor： FRANKE ALBRECHT , MUELLER JOSEF , LIETZ HELMUT , WIERSDORF WALTER-WIELANT , HEGE HANS-GUENTHER , MUELLER CLAUS D , GRIES JOSEF , LENKE DIETER , VON PHILIPSBORN GERDA , RASCHACK MANFRED
IPC: A61K31/13 , A61K31/445 , A61K31/495 , C07C45/62 , C07C45/71 , C07C45/73 , C07C45/74 , C07C49/83 , C07C49/835 , C07C49/84 , C07D211/46 , C07D211/52 , C07D295/08 , C07D295/092 , C07D303/22 , C07D303/24 , C07C97/10 , C07C93/06 , C07D295/10 , C07D341/12 , A61K31/135 , A61K31/395
Abstract: Novel aminopropanol derivatives of 2-hydroxy- beta -phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.
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公开(公告)号：DK84983A
公开(公告)日：1983-08-26
申请号：DK84983
申请日：1983-02-24
Applicant: BASF AG
Inventor： MUELLER JOSEF , WIERSDORFF WALTER-WIELANT , KIRSCHENLOHR WERNER , SCHWANTJE GERD
IPC: C07C231/00 , C07C67/00 , C07C231/02 , C07C231/12 , C07C233/02 , C07C233/13 , C07C
Abstract: 1. A process for the preparation of an o-acylaminomethylbenzyl halide of the formula (I) see diagramm : EP0087676,P5,F3 where X is halogen and R**1 is an aliphatic or aromatic radical, wherein an o-aminomethylbenzyl alkyl ether of the formula (II) see diagramm : EP0087676,P5,F4 where R**2 is alkyl, is reacted with an acylating agent to give the corresponding acylaminomethylbenzyl alkyl ether, and the latter is reacted with an aqueous hydrohalic acid to give the halide (I).
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公开(公告)号：DK164699C
公开(公告)日：1992-12-21
申请号：DK416082
申请日：1982-09-17
Applicant: BASF AG
Inventor： FRANKE ALBRECHT , MUELLER JOSEF , LIETZ HELMUT , WIERSDORFF WALTER-WIELANT , HEGE HANS-GUENTHER , MUELLER CLAUS D , GRIES JOSEF , LENKE DIETER , PHILIPSBORN GERDA VON , RASCHACK MANFRED
IPC: A61K31/13 , A61K31/445 , A61K31/495 , C07C45/62 , C07C45/71 , C07C45/73 , C07C45/74 , C07C49/83 , C07C49/835 , C07C49/84 , C07D211/46 , C07D211/52 , C07D295/08 , C07D295/092 , C07D303/22 , C07D303/24 , C07C217/36 , C07C323/25 , C07D207/08 , C07D211/14 , C07D295/088
Abstract: Novel aminopropanol derivatives of 2-hydroxy- beta -phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.
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公开(公告)号：DK438388A
公开(公告)日：1989-02-07
申请号：DK438388
申请日：1988-08-05
Applicant: BASF AG
Inventor： BIRNBACH STEFAN , MUELLER JOSEF , WULZ KLAUS , HOUBEN JOCHEN
Abstract: Etherified polyoxyalkylene derivatives of the formula where R1 is hydrogen, C1-C20-alkyl or C3-C5-alkenyl, R2 and R3 independently of one another are each hydrogen, methyl or ethyl, R4 is C1-C4-alkyl and m and n are identical or different and are each greater than or equal to 0, with the proviso that the sum of m and n is from 3 to 300, are prepared by reacting the corresponding hydroxyl-containing polyoxyalkylene derivative with a dialkyl sulfate in the presence of an alkali metal hydroxide by a process in which the reaction is carried out at from 20 DEG to 60 DEG C. in the presence of an aqueous solution of an alkali metal hydroxide, the concentration of alkali metal hydroxide during the entire duration of the reaction being not less than 35% by weight, based on the aqueous phase, and not less than 1 mole of dialkyl sulfate and not less than one mole of alkali metal hydroxide are used per mole equivalent of organic hydroxyl groups.
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