公开(公告)号：CA2360227A1

公开(公告)日：2000-07-20

申请号：CA2360227

申请日：2000-01-07

Applicant: BASF AG

Inventor： EASON RAYMOND ,  THOMPSON RICHARD C ,  MULLER BERND W ,  HACH HARALD ,  EINIG HEINZ

IPC: A61K9/20 ,  A61K31/19 ,  A61K31/192 ,  A61K31/485 ,  A61K31/52 ,  A61K45/00 ,  A61K47/14 ,  A61K47/30 ,  A61K47/36 ,  A61K47/38 ,  A61P27/16 ,  A61P29/00 ,  A61K31/137 ,  A61K31/522

Abstract: A pharmaceutical mixture comprising a profen and one or more additional acti ve compounds is described which has a total active compound content of over 85 % and contains up to 1 %, based on the content of the profen, of a nonionic surfactant having an HLB of >= 9 and a customary disintegrant and a lubri cant.

公开(公告)号：PT1128820E

公开(公告)日：2004-07-30

申请号：PT00912425

申请日：2000-01-07

Applicant: BASF AG

Inventor： EINIG HEINZ ,  HACH HARALD ,  EASON RAYMOND ,  MULLER BERND W ,  THOMPSON RICHARD C

IPC: A61K9/20 ,  A61K31/19 ,  A61K31/192 ,  A61K31/485 ,  A61K31/52 ,  A61K45/00 ,  A61K47/14 ,  A61K47/30 ,  A61K47/36 ,  A61K47/38 ,  A61P27/16 ,  A61P29/00 ,  A61K31/522

Abstract: A pharmaceutical mixture comprising a profen and one or more additional active compounds is described which has a total active compound content of over 85% and contains up to 1%, based on the content of the profen, of a nonionic surfactant having an HLB of >=9 and a customary disintegrant and a lubricant.

公开(公告)号：CZ20012553A3

公开(公告)日：2001-10-17

申请号：CZ20012553

申请日：2000-01-07

Applicant: BASF AG

Inventor： EINIG HEINZ ,  HACH HARALD ,  EASON RAYMOND ,  MULLER BERND W ,  THOMPSON RICHARD C

IPC: A61K9/20 ,  A61K31/19 ,  A61K31/192 ,  A61K31/485 ,  A61K31/52 ,  A61K45/00 ,  A61K47/14 ,  A61K47/30 ,  A61K47/36 ,  A61K47/38 ,  A61P27/16 ,  A61P29/00 ,  A61K31/522

Abstract: A pharmaceutical mixture comprising a profen and one or more additional active compounds is described which has a total active compound content of over 85% and contains up to 1%, based on the content of the profen, of a nonionic surfactant having an HLB of >=9 and a customary disintegrant and a lubricant.

公开(公告)号：AU3420600A

公开(公告)日：2000-08-01

申请号：AU3420600

申请日：2000-01-07

Applicant: BASF AG

Inventor： EINIG HEINZ ,  HACH HARALD ,  EASON RAYMOND ,  MULLER BERND W ,  THOMPSON RICHARD C

IPC: A61K9/20 ,  A61K31/19 ,  A61K31/192 ,  A61K31/485 ,  A61K31/52 ,  A61K45/00 ,  A61K47/14 ,  A61K47/30 ,  A61K47/36 ,  A61K47/38 ,  A61P27/16 ,  A61P29/00 ,  A61K31/522

Abstract: A pharmaceutical mixture comprising a profen and one or more additional active compounds is described which has a total active compound content of over 85% and contains up to 1%, based on the content of the profen, of a nonionic surfactant having an HLB of >=9 and a customary disintegrant and a lubricant.

公开(公告)号：ES2218138T3

公开(公告)日：2004-11-16

申请号：ES00912425

申请日：2000-01-07

Applicant: BASF AG

Inventor： EINIG HEINZ ,  HACH HARALD ,  EASON RAYMOND ,  MULLER BERND W ,  THOMPSON RICHARD C

IPC: A61K9/20 ,  A61K31/19 ,  A61K31/192 ,  A61K31/485 ,  A61K31/52 ,  A61K45/00 ,  A61K47/14 ,  A61K47/30 ,  A61K47/36 ,  A61K47/38 ,  A61P27/16 ,  A61P29/00 ,  A61K31/522

Abstract: A pharmaceutical mixture comprising a profen and one or more additional active compounds is described which has a total active compound content of over 85% and contains up to 1%, based on the content of the profen, of a nonionic surfactant having an HLB of >=9 and a customary disintegrant and a lubricant.

公开(公告)号：CZ20012228A3

公开(公告)日：2002-07-17

申请号：CZ20012228

申请日：1999-12-14

Applicant: BASF AG

Inventor： EINIG HEINZ ,  HACH HARALD ,  THOMPSON RICHARD C ,  EASON RAYMOND ,  MULLER BERND W

IPC: A61K9/20 ,  A61K9/28 ,  A61K9/36 ,  A61K31/19 ,  A61K31/192 ,  A61P29/00

Abstract: A pharmaceutical mixture comprising a profen is described which has a profen content of over 85 % and contains up to 1% of a nonionic surfactant having an HLB of >/=9 and also a customary disintegrant and a lubricant and optionally a microcrystalline cellulose.

公开(公告)号：CA2464756A1

公开(公告)日：2003-05-15

申请号：CA2464756

申请日：2002-10-25

Applicant: BASF AG

Inventor： MULLER BERND W ,  FRIESE KATRIN ,  RASENACK NORBERT ,  EINIG HEINZ ,  FRANKE DIRK

IPC: A61K9/20 ,  A61K9/14 ,  A61K9/16 ,  A61K9/26 ,  A61K31/192 ,  A61P29/00 ,  C07C51/43 ,  C07C51/50 ,  C07C57/30 ,  C07C59/64

Abstract: The invention relates to a method for the formation of ibuprofen crystals, characterised in that the solidification occurs after crystallisation by displacement, crystallisation by cooling, crystallisation by evaporation or a combination thereof in the presence of one or several additives and the use of the ibuprofen produced as above for pharmaceutical formulations.