AMINO DERIVATIVES OF 4-HYDROXY-1,2-BENZISOTHIAZOLE

    公开(公告)号:CA1103680A

    公开(公告)日:1981-06-23

    申请号:CA296200

    申请日:1978-02-03

    Applicant: BASF AG

    Abstract: : New aminopropanolderivatives of 4-hydroxy-1,2-benzisothiazole and their addition salts with acids, their preparation, and pharmaceutical formulations which contain the said compounds and may be used for the treatment and prophylaxis of cardiac and circulatory disorders. These new compounds have the following general formula I : (I) where R is hydrogen or alkyl of 1 to 8 carbon atom which may be unsubstituted or substituted by hydroxyl, alkoxy of 1 to 3 carbon atoms, alkylthio of 1 to 3 carbon atoms, dialkylamino (where alkyl is of 1 to 5 carbon atoms), cycloalkylamino of 3 to 7 carbon atoms in the ring, piperidine or cycloalkyl of 3 to 8 carbon atoms in the ring, or is alkenyl or alkynyl of 2 to 8 carbon atoms, or is cycloalkyl or cycloalkenyl of 3 to 8 carbon atoms in the ring or bicycloalkyl of 5 to 8 carbon atoms, the cycloalkyl rings being unsubstituted or substituted by lower alkyl of 1 to 3 carbon atoms, and its addition salts with physiologically safe acids.

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