公开(公告)号：DE4420751A1

公开(公告)日：1995-12-21

申请号：DE4420751

申请日：1994-06-15

Applicant: BASF AG

Inventor： STAUDENMAIER HORST RALF DR ,  HAUER BERNHARD DR ,  BALKENHOHL FRIEDHELM DR ,  LADNER WOLFGANG DR ,  SCHNELL URSULA DR ,  PRESLER UWE DR

IPC: C12P17/10 ,  C12P41/00 ,  C12R1/01 ,  C12R1/38 ,  C07C201/16 ,  C07D227/087 ,  C07D207/267 ,  C07D203/00 ,  C07D205/08 ,  C07D211/76

Abstract: Prodn. of enantiomeric lactams of formula (I) comprises reacting a racemate (I) with a biocatalyst which reacts with one enantiomer and isolating the unreacted enantiomer from the mixt. obtd. R1, R2 = 1-4C alkyl, 2-4C alkenyl or aryl (all opt. substd.), H or (CH2)n-COOH; n = 0-3; x = 1-5. Pref. the biocatalyst is a microorganism, esp. from Pseudomonas or Rhodococcus.

公开(公告)号：DE19625137A1

公开(公告)日：1998-01-08

申请号：DE19625137

申请日：1996-06-24

Applicant: BASF AG

Inventor： BALK ROELOF DR ,  EIPEL HEINZ ,  PRESLER UWE DR

IPC: C12Q1/66 ,  G01N33/44

公开(公告)号：DE4434172A1

公开(公告)日：1996-03-28

申请号：DE4434172

申请日：1994-09-24

Applicant: BASF AG

Inventor： KRATZ DETLEF DR ,  WITZEL TOM DR ,  BAEZNER RUDOLF DR ,  KRONER MATTHIAS DR ,  PRESLER UWE DR

IPC: C07C227/06 ,  C07C229/24 ,  C07C227/04

Abstract: A process is disclosed for preparing D,L-aspartic acid by heating aqueous solutions of ammonium salts of the maleic acid. The molar ratio of maleic acid to ammonia ranges from 1:1 to 1:50. The process is carried out at temperatures from 60 to 250 DEG C and pressures of at least 1 bar. The pressure applied during the reaction is adjusted to ensure that the reaction mixture is almost completely present in liquid phase. Excess ammonia is removed and the reaction solution is acidified so as to release D,L-aspartic acid, which is then isolated.