公开(公告)号：BRPI0607108A2

公开(公告)日：2010-03-09

申请号：BRPI0607108

申请日：2006-01-30

Applicant: BASF AG

Inventor： SCHIEWECK FRANK ,  GROTE THOMAS ,  NAVE BARBARA ,  SCHWIGLER ANJA ,  JABS THORSTEN ,  BLETTNER CARSTEN ,  RHEINHEIMER JOACHIM ,  MUELLER BERND

IPC: A61K31/506 ,  A61K31/505 ,  C07D239/42 ,  C07D239/48 ,  C07D401/04 ,  C07D403/04 ,  C07D417/04

Abstract: The present invention relates to substituted 5-phenyl pyrimidines I, which carry a radical X in the 4-position of the pyrimidine ring, a radical Y in the 6-position of the pyrimidine ring, the radical X denoting a group of the formula NR 1 R 2 , OR 1a or SR 1a , in which R 1 , R 2 , independently of each other, denote hydrogen, C 1 -C 10 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 1 -C 10 -haloalkyl, C 3 -C 8 -cycloalkyl, C 3 -C 8 -halocycloalkyl, phenyl, or 5- or 6-membered heteroaryl or 5- or 6-membered heterocyclyl, containing 1, 2, 3 or 4 nitrogen atoms or 1, 2 or 3 nitrogen atoms and one sulfur or oxygen atom as ring members, which radicals may be unsubstituted or may carry 1, 2, 3 or 4 radicals R a1 ; or the radical NR 1 R 2 may also form a 5- or 6-membered optionally substituted heterocyclic ring, containing 1, 2, 3 or 4 nitrogen atoms or 1, 2 or 3 nitrogen atoms and one sulfur or oxygen atom as ring members, which are non-adjacent to the nitrogen of NR 1 R 2 , in which two adjacent C atoms or one N atom and one adjacent C atom can be linked by a C 1 -C 4 -alkylene chain and wherein the heterocyclic ring may be unsubstituted or may carry 1, 2, 3 or 4 radicals R a1 as defined in claim 1 , R 1a has one of the meanings given for R 1 except for hydrogen; the radical Y being selected from the group consisting of halogen, cyano, C 1 -C 4 -alkyl, C 2 -C 4 -alkenyl, C 2 -C 4 -alkynyl, C 3 -C 6 -cycloalkyl, C 1 -C 4 -alkoxy, C 3 -C 4 -alkenyloxy, C 3 -C 4 -alkynyloxy, C 1 -C 6 -alkylthio, di-(C 1 -C 6 -alkyl)amino or C 1 -C 6 -alkylamino, where the alkyl, alkenyl and alkynyl radicals of Y may be substituted by halogen, cyano, nitro, C 1 -C 2 -alkoxy or C 1 -C 4 -alkoxycarbonyl; and wherein the pyrimidine radical may also carry a radical different from hydrogen in the 2-position and wherein the phenyl ring in the 5-position of the pyrimidine ring may be unsubstituted or carry 1, 2, 3, 4 or 5 radicals L which are different from hydrogen, and the pharmaceutically acceptable salts substituted 5-phenyl pyrimidines for use in therapy, in particular in therapy or treatment of cancerous diseases.

公开(公告)号：CR8844A

公开(公告)日：2007-08-28

申请号：CR8844

申请日：2007-01-10

Applicant: BASF AG

Inventor： GRAMMENOS WASSILIOS ,  GROTE THOMAS ,  BLETTNER CARSTEN ,  GEWEHR MARKUS ,  HUNGER UDO ,  MULLER BERND ,  RHEINHEIMER JOACHIM ,  SCHAFER PETER ,  SCHIEWECK FRANK ,  SCHWIGLER ANJA ,  SCHIFL ULRICH ,  KIHLE HARALD ,  STRATHMANN SIEGFRIED ,  SCHERER MARIA ,  STIERL REINHARD ,  RETHER JAN

IPC: A01N43/54 ,  C07D401/04

Abstract: Compuestos de 2-(piridin-2-il)-pirimidinas de la formula general I y su uso 5 para combatir hongos daninos, asi como los agentes fitosanitarios que contienen estos compuestos corno componente activo, aqui, k es 0, 1,2, o 3, m es 0,1,2,3,4 o 5, n es l,2,3, 4, o 5; R1 es, de modo independiente entre si, halogeno, OH, CN, NO2, alquilo C1-C4, halogenalquilo C1-C4, alcoxi C1-C4, halogenalcoxi C1-C4, alquenilo C2-C4, alquinilo C2-C4, cicloalquilo C3-C6, alcoxi C1-C4-alquilo C1-C4, amino, fenoxi, que eventualmente esta sustituido por halogeno o alquilo C1-C4, NHR, NR2, C(R¬)=N-ORb, S(=O)pA1 o C(=O)A2, o dOs radicales R1 unidos a atomos de C adyacentes tambien pueden ser juntos un grupo -O-Alk-O-, en donde Alk es alquileno C1-04 lineal o ramificado, en donde 1, 2, 3 o 4 atomos de hidrogeno tambien pueden estar reemplazados por halogeno; R2 es halogenalquilo C1-C4, alcoxi C1-C4, halogenalcoxi C1-C4, hidroxi, halogeno, CN o NO2 en donde R2 tambien puede ser hidrogeno o alquilo C1-04 cuando se cumple al menos una de las dos condiciones siguientes - n es 3,4 o5, - k es l,2 o 3, y R3 es alquilo C1-C4.