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公开(公告)号：CA2333888C
公开(公告)日：2008-10-14
申请号：CA2333888
申请日：1999-05-28
Applicant: BASF AG
Inventor： STURMER RAINER , BORNER ARMIN , VOSS GUDRUN , HOLZ JENS
IPC: C07F9/6568 , B01J31/24 , C07B53/00 , C07B61/00 , C07C45/50 , C07C51/36 , C07C55/02 , C07C67/303 , C07C69/34 , C07C231/12 , C07C233/47 , C07F15/00
Abstract: The invention relates to phospholanes and diphospholanes of general formula (I), whereby R represents H, C1-C6-alkyl, aryl, alkyl aryl, SiR2 3, R2 represents alkyl or aryl, A represents H, C1-C6-alkyl, aryl, Cl, or (a), and B represents a binding link with 1-5 C-atoms between both P-atoms. The invention also relates to the use of said phospholanes and diphospholanes as a catalyst in asymmetric synthesis.
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公开(公告)号：AU2003251677A1
公开(公告)日：2004-02-23
申请号：AU2003251677
申请日：2003-07-31
Applicant: BASF AG
Inventor： STURMER RAINER
IPC: C07D333/20 , C07B57/00
Abstract: The present invention relates to a process for the preparation of enantiomerically pure (S)-3-methyl-amino-1-(thien-2-yl)propan-1-ol of the formula II-S by obtainment of (S)-3-hydroxy-3-thien-2-ylpropionitrile from its enantiomer mixture with the R isomer and the subsequent reaction of (S)-3-hydroxy-3-thien-2-ylpropionitrile with hydrogen and methylamine in the presence of a catalyst to give II-S.
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公开(公告)号：ES2170415T3
公开(公告)日：2002-08-01
申请号：ES97943881
申请日：1997-09-23
Applicant: BASF AG
Inventor： GEPRAGS MICHAEL , STURMER RAINER , WEISS HORST , STEIGER SUSANNE
Abstract: PCT No. PCT/EP97/05201 Sec. 371 Date Apr. 14, 1999 Sec. 102(e) Date Apr. 14, 1999 PCT Filed Sep. 23, 1997 PCT Pub. No. WO98/16564 PCT Pub. Date Apr. 23, 1998A catalyst system containing as active constituents A) metal complexes of the formula I wherein the substituents have the meanings set forth in the specification and B) a compound capable of forming metallocenium ions.
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公开(公告)号：ES2169849T3
公开(公告)日：2002-07-16
申请号：ES97909307
申请日：1997-09-23
Applicant: BASF AG
Inventor： GEPRAGS MICHAEL , STURMER RAINER , WEISS HORST , STEIGER SUSANNE
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公开(公告)号：AU8404701A
公开(公告)日：2002-03-13
申请号：AU8404701
申请日：2001-08-30
Applicant: BASF AG
Inventor： HAUER BERNHARD , FRIEDRICH THOMAS , NUBLING CHRISTOPH , STURMER RAINER , LADNER WOLFGANG
IPC: C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/16 , C12N9/18 , C12N15/55 , C12P7/62 , C12P41/00
Abstract: The invention relates to novel proteins from Pseudomonas glumae, having esterase activity, in particular butynol I esterase activity, to nucleic acid sequences coding therefore, to expression cassettes, vectors and recombinant microorganisms; to methods for preparing said proteins and to the use thereof for enzymic, in particular enantioselective enzymic, ester hydrolysis or transesterification of organic esters.
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Patent Agency Ranking
公开(公告)号：CA2419275A1
公开(公告)日：2002-03-07
申请号：CA2419275
申请日：2001-08-30
Applicant: BASF AG
Inventor： NUBLING CHRISTOPH , STURMER RAINER , LADNER WOLFGANG , FRIEDRICH THOMAS , HAUER BERNHARD
IPC: C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/16 , C12N9/18 , C12N15/55 , C12P7/62 , C12P41/00 , C12P7/00 , C12N1/20 , C12N15/63
Abstract: The invention relates to novel proteins exhibiting esterase activity, in particular butinol I esterase activity, obtained from Pseudomonas glumae and to nucleic acid sequences that code therefor, expression cassettes, vectors and recombinant microorganisms. The invention also relates to a method for producing said proteins and to the use thereof for the enzymatic, in particular, enantioselective ester hydrolysis or interesterification of organic esters.
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公开(公告)号：ES2188176T3
公开(公告)日：2003-06-16
申请号：ES99926460
申请日：1999-05-28
Applicant: BASF AG
Inventor： STURMER RAINER , BORNER ARMIN , HOLZ JENS , VOSS GUDRUN
IPC: B01J31/24 , C07B53/00 , C07B61/00 , C07C45/50 , C07C51/36 , C07C55/02 , C07C67/303 , C07C69/34 , C07C231/12 , C07C233/47 , C07F9/6568 , C07F15/00
Abstract: Phospolanes and diphospholanes of the general formula Iwhere: is H, C 1 -C 6 -aryl, alkylaryl, SiR 3 , R is alkyl or aryl, A is H, C 1 -C 6 -alkyl, aryl, Cl orB is a linker with 1-5 C atoms between the two P atoms, and their use as catalyst in asymmetric synthesis.
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公开(公告)号：AU2002304725A1
公开(公告)日：2002-11-05
申请号：AU2002304725
申请日：2002-04-08
Applicant: BASF AG
Inventor： STURMER RAINER , FRIEDRICH THOMAS , ZIMMERMANN NORBERT
IPC: C07D211/20 , C07D265/30 , C07D279/12 , C12N9/06 , C12P7/04 , C12P7/18 , C12P7/22 , C12P13/00 , C12P13/24 , C12P17/10 , C12P17/12 , C12P17/14
Abstract: The invention relates to methods for reacting (di)amines as substrates in the presence of a lysine oxidase arid a reducing agent, resulting in alcohols, diols or cyclic secondary amines. In a particular embodiment, the invention is directed to methods of preparing cyclic secondary amines suitable for ultimately synthesizing piperidine-2-carboxylic acid and proline derivatives, useful, for example as thrombin inhibitors.
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公开(公告)号：CA2337884A1
公开(公告)日：2000-02-03
申请号：CA2337884
申请日：1999-07-02
Applicant: BASF AG
Inventor： STURMER RAINER
Abstract: The present invention relates to novel enzyme-containing polymers, having at least one of the following structural elements (1 and 2), wherein the abbreviations and symbols have the following meaning: E stands for enzyme; X 1, X2 independently represent oxygen, sulfur or NH from a functional group of t he enzyme; Q represents hydrogen or group (a); A1, A2, A3, A4 independently represent oxygen or sulfur; p is 0 or 1 with the proviso that A1, A2, A3 and A4 represent oxygen when p = 0; w is 1-4; q is 1-4; v is 1-100; R1 represent s an optionally substituted or functionalized hydrocarbon group with two to fi ve bonds; R2 represents an optionally substituted or functionalized hydrocarbon group with two to five bonds; R4 and R5 independently represent hydrogen, a C1- C4-alkyl, aryl or alkylaryl group. The invention further relates to a method for the production of said enzyme-containing polymers, their utilization as catalysts in chemical reactions and their use for separating enantiomer mixtures.
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公开(公告)号：ES2278203T3
公开(公告)日：2007-08-01
申请号：ES03766383
申请日：2003-07-31
Applicant: BASF AG
Inventor： STURMER RAINER
IPC: C07D333/20 , C07B57/00
Abstract: Un proceso para la preparación de (S)-3-metilamino-1-(tien-2-il)propan-1-ol enantioméricamente puro de fórmula II-S que abarca los pasos siguientes: a) reacción de una mezcla del enantiómero de los alcoholes (S)-3-hidroxi-3-tien-2-ilpropionitrilo y (R)-3-hidroxi-3-tien-2-ilpropionitrilo de las fórmulas I-S e I-R con un agente acilante en la presencia de una lipasa, una mezcla del alcohol I-S esencialmente no acilado y del alcohol I-R esencialmente acilado obtenido; b) la separación del alcohol I-S de la mezcla obtenida en el paso a); y c) la reacción del alcohol I-S con hidrógeno y metilamina en la presencia de un catalizador para dar (S)-3-metilamino-1-(tien-2-il)propan-1-ol II-S.
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