公开(公告)号：AU765446B2

公开(公告)日：2003-09-18

申请号：AU1036500

申请日：1999-10-13

Applicant: BASF AG

Inventor： BISCHOF NORBERT ,  BUSCHMANN ERNST ,  HENNINGSEN MICHAEL ,  KREI GEORG ARNOLD ,  MUNSCHAUER RAINER ,  PFEIFFER THOMAS ,  STEINER GERD ,  VIERGUTZ WOLFGANG

IPC: C07D209/52 ,  A61K31/40 ,  C07B37/10 ,  C07D20060101

Abstract: A process for preparing (+)-exo-6-phenyl-3-azabicyclo[3.2.0]heptanes of the formula Iwhere R is hydrogen, chlorine, bromine, fluorine or methoxy, which comprises photocyclizing a bisallylammonium salt of the formula IIwhere R has the meanings given above and X- is an anion, in an inert solvent in a glass apparatus with addition of sensitizer and precipitating using (-)-ditoluoyltartaric acid the desired (+)-exo-isomer I as ditoluoyltartrate from the resulting mixture, with or without recrystallization of this tartrate from an alcohol/water mixture.

公开(公告)号：DE59807019D1

公开(公告)日：2003-02-27

申请号：DE59807019

申请日：1998-05-04

Applicant: BASF AG

Inventor： VIERGUTZ WOLFGANG ,  KOSER STEFAN

IPC: C07D209/48 ,  C07D221/14

Abstract: Bisimides of the formula Iwhere R1, R2, R3 and R4 have the meanings stated in the description, are prepared in a process in which the corresponding dicarboxylic anhydrides of the formulae II and IIIare reacted with an amine of the formula H2N-R-NH2 in the presence of a tertiary amine.

公开(公告)号：CA2347757A1

公开(公告)日：2000-04-27

申请号：CA2347757

申请日：1999-10-13

Applicant: BASF AG

Inventor： MUNSCHAUER RAINER ,  VIERGUTZ WOLFGANG ,  BUSCHMANN ERNST ,  STEINER GERD ,  BISCHOF NORBERT ,  PFEIFFER THOMAS ,  KREI GEORG ARNOLD ,  HENNINGSEN MICHAEL

IPC: C07D209/52 ,  A61K31/40 ,  C07B37/10 ,  C07D20060101

Abstract: The invention relates to a method for producing (+)-exo-6-phenyl-3-azabicycl o- [3.2.0]heptanes of formula (I) in which R represents hydrogen, chlorine, bromine, fluorine or methoxy. The inventive compounds are characterized in that a bisallyl ammonium salt of formula (II), in which R has the above- mentioned meanings and X- represents an anion, is photo-cyclized in an inert solvent while adding a sensitizer in a glass apparatus, and the selected (+) - exo-isomer (I) is precipitated as ditoluoyl tartrate using (-)-ditoluoyl tartaric acid from the obtained mixture, and this ditoluoyl tartrate is optionally recrystallized out of an alcohol/water mixture.

公开(公告)号：CA2167406A1

公开(公告)日：1995-01-26

申请号：CA2167406

申请日：1994-06-28

Applicant: BASF AG

Inventor： VIERGUTZ WOLFGANG ,  THYES MARCO

IPC: C07D471/08

Abstract: Described is an improved method of preparing N,N'-dibenzylbispidine by reacting N-benzylpiperidone with benzylamine and subsequent reduction.

公开(公告)号：HU0104127A2

公开(公告)日：2002-03-28

申请号：HU0104127

申请日：1999-10-13

Applicant: BASF AG

Inventor： BISCHOF NORBERT ,  BUSCHMANN ERNST ,  HENNINGSEN MICHAEL ,  KREI GEORG ARNOLD ,  MUNSCHAUER RAINER ,  PFEIFFER THOMAS ,  STEINER GERD ,  VIERGUTZ WOLFGANG

IPC: C07D209/52 ,  A61K31/40 ,  C07B37/10 ,  C07D20060101

Abstract: A process for preparing (+)-exo-6-phenyl-3-azabicyclo[3.2.0]heptanes of the formula Iwhere R is hydrogen, chlorine, bromine, fluorine or methoxy, which comprises photocyclizing a bisallylammonium salt of the formula IIwhere R has the meanings given above and X- is an anion, in an inert solvent in a glass apparatus with addition of sensitizer and precipitating using (-)-ditoluoyltartaric acid the desired (+)-exo-isomer I as ditoluoyltartrate from the resulting mixture, with or without recrystallization of this tartrate from an alcohol/water mixture.

公开(公告)号：CZ20011422A3

公开(公告)日：2001-08-15

申请号：CZ20011422

申请日：1999-10-13

Applicant: BASF AG

Inventor： BISCHOF NORBERT ,  BUSCHMANN ERNST ,  HENNINGSEN MICHAEL ,  KREI GEORG ARNOLD ,  MUNSCHAUER RAINER ,  PFEIFFER THOMAS ,  STEINER GERD ,  VIERGUTZ WOLFGANG

IPC: C07D209/52 ,  A61K31/40 ,  C07B37/10 ,  C07D20060101

Abstract: A process for preparing (+)-exo-6-phenyl-3-azabicyclo[3.2.0]heptanes of the formula Iwhere R is hydrogen, chlorine, bromine, fluorine or methoxy, which comprises photocyclizing a bisallylammonium salt of the formula IIwhere R has the meanings given above and X- is an anion, in an inert solvent in a glass apparatus with addition of sensitizer and precipitating using (-)-ditoluoyltartaric acid the desired (+)-exo-isomer I as ditoluoyltartrate from the resulting mixture, with or without recrystallization of this tartrate from an alcohol/water mixture.

公开(公告)号：HK1014927A1

公开(公告)日：1999-10-08

申请号：HK99100169

申请日：1999-01-14

Applicant: BASF AG

Inventor： VIERGUTZ WOLFGANG ,  KNOPFF JUERGEN ,  BRASE WALTER

IPC: C07B57/00 ,  C07C59/68 ,  C07C209/88 ,  C07C213/10 ,  C07C215/28 ,  C07C215/30 ,  C07D217/20 ,  C07D217/24 ,  C07B ,  C07D ,  C07C

Abstract: PCT No. PCT/EP96/04030 Sec. 371 Date Feb. 26, 1998 Sec. 102(e) Date Feb. 26, 1998 PCT Filed Sep. 13, 1996 PCT Pub. No. WO97/11927 PCT Pub. Date Apr. 3, 1997A process for resolving racemates of compounds of the formula I in which a, A, B, D, E, F, M, Q and R have the meanings given in the description is described. The process is carried in a manner known per se but using the optical antipodes of derivatives of phenoxypropionic acid. Also described are salts of deprenyl, ephedrine or tetrahydropapaverine with a phenoxypropionic acid of the formula in which U and T have the meaning stated in the description, and which result as intermediate in the racemate resolution.

公开(公告)号：HU9503859D0

公开(公告)日：1996-02-28

申请号：HU9503859

申请日：1994-06-28

Applicant: BASF AG

Inventor： THYES MARCO ,  VIERGUTZ WOLFGANG

IPC: C07D471/08

Abstract: Described is an improved method of preparing N,N'-dibenzylbispidine by reacting N-benzylpiperidone with benzylamine and subsequent reduction.

公开(公告)号：AU7073394A

公开(公告)日：1995-02-13

申请号：AU7073394

申请日：1994-06-28

Applicant: BASF AG

Inventor： VIERGUTZ WOLFGANG ,  THYES MARCO

IPC: C07D471/08

Abstract: Described is an improved method of preparing N,N'-dibenzylbispidine by reacting N-benzylpiperidone with benzylamine and subsequent reduction.

公开(公告)号：CA2347757C

公开(公告)日：2005-05-17

申请号：CA2347757

申请日：1999-10-13

Applicant: BASF AG

Inventor： VIERGUTZ WOLFGANG ,  BUSCHMANN ERNST ,  STEINER GERD ,  PFEIFFER THOMAS ,  KREI GEORG ARNOLD ,  HENNINGSEN MICHAEL ,  BISCHOF NORBERT ,  MUNSCHAUER RAINER

IPC: C07D209/52 ,  A61K31/40 ,  C07B37/10 ,  C07D20060101

Abstract: The invention relates to a method for producing (+)-exo-6-phenyl-3--azabicyc lo- [3.2.0]heptanes of formula (I) in which R represents hydrogen, chlorine, bromine, fluorine or methoxy. The inventive compounds ar e characterized in that a bisallyl ammonium salt of formula (II), in which R has the above-mentioned meanings and X- represents an anion , is photo-cyclized in an inert solvent while adding a sensitizer in a glass apparatus, and the selected (+)-exo-isomer (I) is precipitated as ditoluoyl tartrate using (-)-ditoluoyl tartaric acid from the obtained mixture, and this ditoluoyl tartrate is optionally recrystalliz ed out of an alcohol/water mixture.