USE OF RE-DISPERSIBLE POLYMERIC POWDER OR POLYMERIC GRANULE AS BINDER AND SOLID PHARMACEUTICAL DOSAGE FORM

    公开(公告)号:JPH10298111A

    公开(公告)日:1998-11-10

    申请号:JP5764598

    申请日:1998-03-10

    Applicant: BASF AG

    Abstract: PROBLEM TO BE SOLVED: To obtain a polymeric powder or polymeric granules comprising a water-insoluble polymer and a water-soluble polymer, suitable as a binder for production of solid pharmaceutical dosage forms and capable of rapidly releasing active substance(s). SOLUTION: This polymeric powder or granules as binder comprise(s) 10-95 wt.% of polyvinyl acetate, 5-90 wt.% of an N-vinylpyrrolidone-contg. polymer, 0-20 wt.% of another water-soluble or water-swellable substance and 0-20 wt.% of a water-insoluble pulverizing agent, and in some cases, other additive(s). The content of the binder in the other objective dosage form is 0.5-20 wt.%. This polymeric powder or granules has (have) remarkable binding action, and does not disintegrate the dose form and also does not virtually affect the release of the active substance(s) included in the preparation within the concentration range of 0.5-20 wt.%, based on the whole weight of the prescribed preparation as the dosage form.

    8.
    发明专利
    未知

    公开(公告)号:ES2189997T3

    公开(公告)日:2003-07-16

    申请号:ES98103626

    申请日:1998-03-02

    Applicant: BASF AG

    Abstract: Use of redispersible polymer powders or granules as binders for preparing solid compositions, where the powders or granules comprise: (a) 10-95 wt.% polyvinyl acetate; (b) 5-90 wt.% of a N-vinylpyrrolidone polymer; (c) 0-20 wt.% of another water-soluble or water-swellable material; (d) 0-20 wt.% of a water-insoluble dusting agent; and optionally (e) further additives, and where the proportion of the binder in the dosage form is 0.5-20 wt.%. Also claimed are solid compositions with a binder comprising components (a)-(e) in the amounts specified above, where the binder makes up 0.5-20% of the total.

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