公开(公告)号：DE59801326D1

公开(公告)日：2001-10-04

申请号：DE59801326

申请日：1998-05-13

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  ZETTLER DIETER

IPC: A61K9/16 ,  B01J2/20 ,  B29C47/00 ,  B29C47/40 ,  B29C47/78 ,  B29C48/395 ,  B29C48/67 ,  B29C47/64

Abstract: A process for the continuous production of solid, particulate preparations of bioactive substances, in which the bioactive substances are homogeneously dispersed in a matrix of thermoplastic auxiliaries, in a screw extruder divided into a plurality of zones, wherein there is firstly melting of the matrix auxiliaries and mixing of the bioactive components with the matrix auxiliaries in a heatable zone, after which the mixture is cooled, precomminuted and finely ground in a cooling zone, the screw geometry in the cooling zone being selected so that the cooling zone consists of a conveying zone, a mixing zone and a kneading zone.

公开(公告)号：DE59806555D1

公开(公告)日：2003-01-16

申请号：DE59806555

申请日：1998-08-13

Applicant: BASF AG

Inventor： BERBNER HEINZ ,  ETLING HANS ,  GUENTHER ERHARD ,  SIRCH TILMAN ,  ZETTLER DIETER

IPC: B29C48/38 ,  B29C47/00 ,  B29C48/76 ,  B29C67/24 ,  C08G8/00 ,  C08G12/12 ,  C08G12/32 ,  C08G14/00 ,  B29C47/50 ,  B29C47/76

Abstract: The invention relates to a continuous process for preparing aminoplastics and/or phenolics, in which a precondensate solution is prepared in a first extruder (14), the precondensate solution is continuously fed, with addition of additives, to a second extruder (20) with partial filling in the feed section (E) and devolatilization section (G), devolatilized in the second extruder (20) and then formed to give a molding composition or an end product. The process is particularly suitable for preparing melamine resins, in particular melamine-formaldehyde resins, as well as for preparing urea-formaldehyde resins.

公开(公告)号：DE59609104D1

公开(公告)日：2002-05-23

申请号：DE59609104

申请日：1996-10-23

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  HAERTL PAUL ,  HOFMANN JUERGEN ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  ZETTLER DIETER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60

Abstract: PCT No. PCT/EP96/04601 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Oct. 23, 1996 PCT Pub. No. WO97/15293 PCT Pub. Date May 1, 1997The present invention relates to a process for producing multilayer, solid drug forms for oral or rectal administration, which comprises coextrusion of at least two compositions which in each case comprise a thermoplastic, pharmacologically acceptable polymeric binder which is soluble or swellable in a physiological environment, and at least one of which contains a pharmaceutical active ingredient, and shaping the coextruded multilayer material to the required drug form.

公开(公告)号：DE59605682D1

公开(公告)日：2000-09-07

申请号：DE59605682

申请日：1996-04-22

Applicant: BASF AG

Inventor： BERBNER HEINZ ,  GIHR HARTMUT ,  RACHWALSKY UWE ,  ZETTLER DIETER

IPC: C08G12/32 ,  D01F6/76 ,  D03D15/00 ,  D03D15/12 ,  D04H1/42

Abstract: A process is disclosed for producing filaments from a hydroxy- or aminoalkylmelamine-modified melamine/formaldehyde condensation product. The highly concentrated aqueous solution of a melamine/formaldehyde condensation product is filtered, extruded through a spinning nozzle, the extruded threads are dried in a dry shaft by means of hot air, and the dried threads are processed in a tempering furnace at temperatures that rise progressively up to a maximum temperature from 160 to 250 DEG C, thus hardening the pre-condensed product.