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公开(公告)号：WO0143660A3
公开(公告)日：2002-01-10
申请号：PCT/US0042718
申请日：2000-12-08
Applicant: BAXTER INT
Inventor： PEKKARINEN MICHAEL O , BRAUKER JAMES
CPC classification number: A61F2/02 , A61F2/00 , A61F2/0077 , A61F2/022 , A61F2/06 , A61F2/30767 , A61F2/3094 , A61F2002/30154 , A61F2002/30199 , A61F2002/30263 , A61F2002/30271 , A61F2002/30329 , A61F2002/30677 , A61F2002/307 , A61F2002/30701 , A61F2002/30703 , A61F2220/0025 , A61F2230/0021 , A61F2230/0063 , A61F2230/0082 , A61F2230/0084 , A61F2240/001 , A61F2250/0067 , A61F2250/0081
Abstract: A porous three dimensional structure (10) for implantation in a host animal capable of producing an inflammatory foreign body response. The structure includes first and second layers (12, 14) spaced by a plurality of posts (16) having a predetermined length connecting the first and second layers. Each of the layers has a plurality of openings (18, 20) of a predetermined size permitting fluids and inflammatory cells of the animal to pass through the openings and migrate into an interior volume (30) defined by the first and second layers. The size of the openings and length of the posts promote a non-flattened morphology of the cells. The structure promotes vascularization adjacent to the structure when implanted into the animal.
Abstract translation: 一种用于植入能够产生炎症异物反应的宿主动物中的多孔三维结构（10）。 该结构包括由连接第一和第二层的具有预定长度的多个柱（16）隔开的第一和第二层（12,14）。 每个层具有多个预定尺寸的开口（18,20），允许动物的流体和炎性细胞穿过开口并迁移到由第一和第二层限定的内部容积（30）中。 开口的尺寸和柱的长度促进了细胞的非扁平形态。 当植入植物时，该结构促进与结构相邻的血管形成。
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公开(公告)号：AU1526095A
公开(公告)日：1995-08-01
申请号：AU1526095
申请日：1995-01-09
Applicant: BAXTER INT
Inventor： NEUENFELDT STEVEN , BRAUKER JAMES , CLARKE ROBERT , CARR-BRENDEL VICTORIA
Abstract: A method for implanting cells into a host tissue is provided. The method comprises the steps of: creating an implant assembly for holding cells including wall means for forming a porous boundary between the host tissue and the implanted cells in the device, the pore size of the boundary being sufficient to isolate the implanted cells from the immune response; implanting the assembly without the cells into a host tissue; and accessing an interior of the assembly to add the cells thereto.
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公开(公告)号：DE69505391D1
公开(公告)日：1998-11-19
申请号：DE69505391
申请日：1995-06-29
Applicant: BAXTER INT
Inventor： GELLER ROBIN , BRAUKER JAMES , JOHNSTON WILLIAM , LEVON STEVEN , MARYANOV DAVID
Abstract: An implantable device for the prevention or treatment of cancer comprising an implantable chamber containing tumor cells, or somatic cells engineered to express at least one antigen corresponding to antigen of a patient's tumor; the chamber having a porous wall to provide, in use, a porous boundary between the patient's immune cells and the contained cells; the porosity of the boundary being sufficient to permit subcellular antigenic material to pass through the boundary, while preventing the contained cells and patient immune cells from passing through the boundary.
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公开(公告)号：CA2156730A1
公开(公告)日：1995-07-13
申请号：CA2156730
申请日：1995-01-09
Applicant: BAXTER INT
Inventor： NEUENFELDT STEVEN , BRAUKER JAMES , CLARKE ROBERT
IPC: C12M1/00 , A61F2/02 , A61L27/00 , A61L27/38 , C12M3/06 , C12N5/06 , C12M3/00 , A61M37/00 , A61K35/12
Abstract: A method and apparatus for implanting cells in a host is provided. In an embodiment, an implant assembly for a host tissue is provided comprising wall means defining a chamber for holding cells for implantation, the wall means including means for forming a porous boundary between the host tissue and the implanted cells in the chamber, the pore size of the boundary being sufficient to isolate the implanted cells from the immune response of the host tissue, and port means for providing selective access to the chamber.
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公开(公告)号：DK0688196T3
公开(公告)日：2002-06-03
申请号：DK95907343
申请日：1995-01-09
Applicant: BAXTER INT
Inventor： NEUENFELDT STEVEN , BRAUKER JAMES , CLARKE ROBERT
Abstract: A method and apparatus for implanting cells in a host is provided. In an embodiment, an implant assembly for a host tissue is provided comprising wall means defining a chamber for holding cells for implantation, the wall means including means for forming a porous boundary between the host tissue and the implanted cells in the chamber, the pore size of the boundary being sufficient to isolate the implanted cells from the immune response of the host tissue, and port means for providing selective access to the chamber.
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Patent Agency Ranking
公开(公告)号：DE69505391T2
公开(公告)日：1999-06-17
申请号：DE69505391
申请日：1995-06-29
Applicant: BAXTER INT
Inventor： GELLER ROBIN , BRAUKER JAMES , JOHNSTON WILLIAM , LEVON STEVEN , MARYANOV DAVID
Abstract: An implantable device for the prevention or treatment of cancer comprising an implantable chamber containing tumor cells, or somatic cells engineered to express at least one antigen corresponding to antigen of a patient's tumor; the chamber having a porous wall to provide, in use, a porous boundary between the patient's immune cells and the contained cells; the porosity of the boundary being sufficient to permit subcellular antigenic material to pass through the boundary, while preventing the contained cells and patient immune cells from passing through the boundary.
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公开(公告)号：DE69526389T2
公开(公告)日：2002-11-28
申请号：DE69526389
申请日：1995-01-09
Applicant: BAXTER INT
Inventor： NEUENFELDT STEVEN , BRAUKER JAMES , CLARKE ROBERT
Abstract: A method and apparatus for implanting cells in a host is provided. In an embodiment, an implant assembly for a host tissue is provided comprising wall means defining a chamber for holding cells for implantation, the wall means including means for forming a porous boundary between the host tissue and the implanted cells in the chamber, the pore size of the boundary being sufficient to isolate the implanted cells from the immune response of the host tissue, and port means for providing selective access to the chamber.
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公开(公告)号：CA2256680A1
公开(公告)日：1998-01-22
申请号：CA2256680
申请日：1997-05-29
Applicant: BAXTER INT
Inventor： MARYANOV DAVID , LOUDOVARIS THOMAS , SHORS STEPHANIE , BRAUKER JAMES , NEUENFELDT STEVEN , DAUGIRD JOANNE , GELLER ROBIN L , FREDERICKSEN SCOTT , JONES MARK
Abstract: An implant assembly and methods for loading implant devices which avoids the accidental deposition of transplanted material or other contaminates on the exterior of the device during transportation, storage, and handling are disclosed. The implant assembly of the invention may be used with a large variety of implant devices for implanting a variety of materials such as cells, tissue or other materials into a host. The implant assembly includes an implant device having an elongated port and a first chamber for holding material for implantation and a container with a second chamber for holding the implant device. The container functions to maintain the sterility and protect the physical integrity of the implant device during loading, storage, cryopreservation and transportation and is removed immediately prior to implantation of the device. The container may optionally include liquid media for cellular growth, maintenance, cryostorage, or transportation purposes.
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公开(公告)号：AU1561095A
公开(公告)日：1995-08-01
申请号：AU1561095
申请日：1995-01-09
Applicant: BAXTER INT
Inventor： NEUENFELDT STEVEN , BRAUKER JAMES , CLARKE ROBERT
Abstract: A method and apparatus for implanting cells in a host is provided. In an embodiment, an implant assembly for a host tissue is provided comprising wall means defining a chamber for holding cells for implantation, the wall means including means for forming a porous boundary between the host tissue and the implanted cells in the chamber, the pore size of the boundary being sufficient to isolate the implanted cells from the immune response of the host tissue, and port means for providing selective access to the chamber.
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公开(公告)号：DE69526389D1
公开(公告)日：2002-05-23
申请号：DE69526389
申请日：1995-01-09
Applicant: BAXTER INT
Inventor： NEUENFELDT STEVEN , BRAUKER JAMES , CLARKE ROBERT
Abstract: A method and apparatus for implanting cells in a host is provided. In an embodiment, an implant assembly for a host tissue is provided comprising wall means defining a chamber for holding cells for implantation, the wall means including means for forming a porous boundary between the host tissue and the implanted cells in the chamber, the pore size of the boundary being sufficient to isolate the implanted cells from the immune response of the host tissue, and port means for providing selective access to the chamber.
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