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公开(公告)号：DE69505391T2
公开(公告)日：1999-06-17
申请号：DE69505391
申请日：1995-06-29
Applicant: BAXTER INT
Inventor： GELLER ROBIN , BRAUKER JAMES , JOHNSTON WILLIAM , LEVON STEVEN , MARYANOV DAVID
Abstract: An implantable device for the prevention or treatment of cancer comprising an implantable chamber containing tumor cells, or somatic cells engineered to express at least one antigen corresponding to antigen of a patient's tumor; the chamber having a porous wall to provide, in use, a porous boundary between the patient's immune cells and the contained cells; the porosity of the boundary being sufficient to permit subcellular antigenic material to pass through the boundary, while preventing the contained cells and patient immune cells from passing through the boundary.
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公开(公告)号：CA2256680A1
公开(公告)日：1998-01-22
申请号：CA2256680
申请日：1997-05-29
Applicant: BAXTER INT
Inventor： MARYANOV DAVID , LOUDOVARIS THOMAS , SHORS STEPHANIE , BRAUKER JAMES , NEUENFELDT STEVEN , DAUGIRD JOANNE , GELLER ROBIN L , FREDERICKSEN SCOTT , JONES MARK
Abstract: An implant assembly and methods for loading implant devices which avoids the accidental deposition of transplanted material or other contaminates on the exterior of the device during transportation, storage, and handling are disclosed. The implant assembly of the invention may be used with a large variety of implant devices for implanting a variety of materials such as cells, tissue or other materials into a host. The implant assembly includes an implant device having an elongated port and a first chamber for holding material for implantation and a container with a second chamber for holding the implant device. The container functions to maintain the sterility and protect the physical integrity of the implant device during loading, storage, cryopreservation and transportation and is removed immediately prior to implantation of the device. The container may optionally include liquid media for cellular growth, maintenance, cryostorage, or transportation purposes.
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公开(公告)号：DE69505391D1
公开(公告)日：1998-11-19
申请号：DE69505391
申请日：1995-06-29
Applicant: BAXTER INT
Inventor： GELLER ROBIN , BRAUKER JAMES , JOHNSTON WILLIAM , LEVON STEVEN , MARYANOV DAVID
Abstract: An implantable device for the prevention or treatment of cancer comprising an implantable chamber containing tumor cells, or somatic cells engineered to express at least one antigen corresponding to antigen of a patient's tumor; the chamber having a porous wall to provide, in use, a porous boundary between the patient's immune cells and the contained cells; the porosity of the boundary being sufficient to permit subcellular antigenic material to pass through the boundary, while preventing the contained cells and patient immune cells from passing through the boundary.
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