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1.发明公开CONTROLLED ADMINISTRATION OF BENEFICIAL AGENT TO BLOOD. 失效GESTEUERTE VERABREICHUNG EINES HEILMITTELS一个BLUT。
公开(公告)号：EP0341291A4
公开(公告)日：1990-07-03
申请号：EP89900112
申请日：1988-11-08
Applicant: BAXTER INT
Inventor： BACEHOWSKI DAVID V , MIRIPOL JEFFREY E , NEEDHAM THOMAS E , KARTINOS NICHOLAS J
CPC classification number: A61M1/3672 , A61M1/3673
Abstract: As one administers blood through a conduit (10) into a container (12), the blood is passed in the conduit across the supply of beneficial agent (18), such as anticoagulant, to cause a controlled amount of beneficial agent to enter the passing blood in a manner that is substantially uniform overtime. The beneficial agent (18) is typically in dry form until it enters into contact with the blood. Accordingly, no substantial portion of the blood is exposed to a significantly higher concentration of the beneficial agent than other portions of the blood.
Abstract translation: 当通过导管（10）将血液施用到容器（12）中时，血液在管道中通过有益剂（18）的供应，例如抗凝血剂，以引起受控量的有益剂进入通过 血液的加班时间基本一致。 有益剂（18）通常是干燥形式，直到其与血液接触。 因此，与血液的其他部分相比，没有相当一部分血液暴露于有益剂量的明显更高的浓度。
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公开(公告)号：CA2031522C
公开(公告)日：1998-08-25
申请号：CA2031522
申请日：1990-01-17
Applicant: BAXTER INT
Inventor： MIRIPOL JEFFREY E , BILSTAD ARNOLD , FOLEY JOHN , GLASH DEAN , BRATTEN WILLIAM R
Abstract: A thin film (10) or layer (10) of white blood cells, such as the contaminating w hite cells in a platelet concentrate, is irradiated with ultraviolet radiation predominantely of a wavelength of 280 to 320 nanomet ers, and preferably at an intensity of 4 to 20 milliwatts per square cm. to provide a total energy exposure of typically 800 to 20,000 millijoules per square cm. of ultraviolet radiation. The white blood cells so processed substantially lose their capabilit y to set off an immune reaction in an alloimmunized patient. The white blood cells may preferably be placed into such film in a flat (10), flexible bag (10) made of poly(ethylene-vinyl acetate) plastic, with the flat (10), flexible bag (10) being stretched in a dir ection normal to the path of ultraviolet radiation. Novel irradiating devices (40) are also disclosed.
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公开(公告)号：CA2031522A1
公开(公告)日：1990-11-03
申请号：CA2031522
申请日：1990-01-17
Applicant: BAXTER INT
Inventor： MIRIPOL JEFFREY E , BILSTAD ARNOLD , FOLEY JOHN , GLASH DEAN , BRATTEN WILLIAM R
Abstract: A thin film or layer of white blood cells, such as the contaminating white cells in a platelet concentrate, is irradiated with ultraviolet radiation predominately of a wavelength of 280 to 320 nanometers, and preferably at an intensity of 4 to 20 milliwatts per square cm. to provide a total energy exposure of typically 800 to 20,000 millijoules per square cm. of ultraviolet radiation. The white blood cells so produced substantially lose their capability to set off an immune reaction in an alloimmunized patient. The white blood cells may preferably be placed into such film in a flat, flexible bag made of poly(ethylene-vinyl acetate) plastic, with the flat, flexible bag being stretched in a direction normal to the path of ultraviolet radiation. Novel irradiating devices are also disclosed.
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公开(公告)号：CA1339088C
公开(公告)日：1997-07-29
申请号：CA582994
申请日：1988-11-14
Applicant: BAXTER INT
Inventor： BACEHOWSKI DAVID V , MIRIPOL JEFFREY E , NEEDHAM THOMAS E , KARTINOS NICHOLAS J
Abstract: As one administers blood through a conduit into a container, the blood is passed in the conduit across the supply of beneficial agent, such as anticoagulant, to cause a controlled amount of beneficial agent to enter the passing blood in a manner that is substantially uniform over time. The beneficial agent is typically in dry form until it enters into contact with the blood. Accordingly, no substantial portion of the blood is exposed to a significantly higher concentration of the beneficial agent than other portions of the blood.
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