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公开(公告)号：AU5338599A
公开(公告)日：2000-02-28
申请号：AU5338599
申请日：1999-08-06
Applicant: BAXTER INT
Inventor： DEFOGGI JOHN MARK , BILSTAD ARNOLD , MCPHILLIAMY INGRID
IPC: A61J1/00
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公开(公告)号：DE69008664T2
公开(公告)日：1994-12-15
申请号：DE69008664
申请日：1990-01-17
Applicant: BAXTER INT
Inventor： MIRIPOL JEFFREY , BILSTAD ARNOLD , FOLEY JOHN , GLASH DEAN , BRATTEN WILLIAM
Abstract: A thin film or layer of white blood cells, such as the contaminating white cells in a platelet concentrate, is irradiated with ultraviolet radiation predominately of a wavelength of 280 to 320 nanometers, and preferably at an intensity of 4 to 20 milliwatts per square cm. to provide a total energy exposure of typically 800 to 20,000 millijoules per square cm. of ultraviolet radiation. The white blood cells so produced substantially lose their capability to set off an immune reaction in an alloimmunized patient. The white blood cells may preferably be placed into such film in a flat, flexible bag made of poly(ethylene-vinyl acetate) plastic, with the flat, flexible bag being stretched in a direction normal to the path of ultraviolet radiation. Novel irradiating devices are also disclosed.
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公开(公告)号：DE69008664D1
公开(公告)日：1994-06-09
申请号：DE69008664
申请日：1990-01-17
Applicant: BAXTER INT
Inventor： MIRIPOL JEFFREY , BILSTAD ARNOLD , FOLEY JOHN , GLASH DEAN , BRATTEN WILLIAM
Abstract: A thin film or layer of white blood cells, such as the contaminating white cells in a platelet concentrate, is irradiated with ultraviolet radiation predominately of a wavelength of 280 to 320 nanometers, and preferably at an intensity of 4 to 20 milliwatts per square cm. to provide a total energy exposure of typically 800 to 20,000 millijoules per square cm. of ultraviolet radiation. The white blood cells so produced substantially lose their capability to set off an immune reaction in an alloimmunized patient. The white blood cells may preferably be placed into such film in a flat, flexible bag made of poly(ethylene-vinyl acetate) plastic, with the flat, flexible bag being stretched in a direction normal to the path of ultraviolet radiation. Novel irradiating devices are also disclosed.
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公开(公告)号：DE68923081D1
公开(公告)日：1995-07-20
申请号：DE68923081
申请日：1989-09-05
Applicant: BAXTER INT
Inventor： BACEHOWSKI DAVID , BILSTAD ARNOLD , FISHER DAVID , GLINIECKI ROBERT , KEILMAN MICHAEL , SMITH SIDNEY
Abstract: A cell culture media container is provided. The container comprises a body constructed from flexible film and defining a containment area for containing the cell culture media, the body including a front face and a back face, the front and back face being sealed to each other along at least three sides thereof. The container includes a fill port for filling the containment area with cell culture media, the port being sealed to a face of the body and being so constructed and arranged that it extends from the face normal thereto. The container is constructed from a high barrier, optically clear, radiation sterilizable film.
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Patent Agency Ranking
公开(公告)号：DE3378612D1
公开(公告)日：1989-01-12
申请号：DE3378612
申请日：1983-10-26
Applicant: BAXTER INT
Inventor： BILSTAD ARNOLD , BROWN RICHARD , KRUGER ROBERT
Abstract: A disposable prepackaged fluid processing module (20) for deriving plasma from whole blood includes an integral housing (22) wherein anticoagulant (ACD), saline and collection containers (43,44, and 30), tubing segments (27,28,31,56,60), a membrane filter element (141), and other components (63) required in the procedure are contained. Fluid communication between the containers, tubing segments and filter element is provided by a fluid circuit formed by a panel (36) of the housing (22), and an overlying fluid-impermeable flexible sheet member (71). The fluid circuit includes pump and valve elements (130-137) which operate in response to pressures applied to the sheet member. Upon installation of the system in a related actuator apparatus (21), pneumatic actuator ports (100-107) apply pressures to the pump and valve elements to circulate fluid through the fluid circuit.
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公开(公告)号：CA2031522C
公开(公告)日：1998-08-25
申请号：CA2031522
申请日：1990-01-17
Applicant: BAXTER INT
Inventor： MIRIPOL JEFFREY E , BILSTAD ARNOLD , FOLEY JOHN , GLASH DEAN , BRATTEN WILLIAM R
Abstract: A thin film (10) or layer (10) of white blood cells, such as the contaminating w hite cells in a platelet concentrate, is irradiated with ultraviolet radiation predominantely of a wavelength of 280 to 320 nanomet ers, and preferably at an intensity of 4 to 20 milliwatts per square cm. to provide a total energy exposure of typically 800 to 20,000 millijoules per square cm. of ultraviolet radiation. The white blood cells so processed substantially lose their capabilit y to set off an immune reaction in an alloimmunized patient. The white blood cells may preferably be placed into such film in a flat (10), flexible bag (10) made of poly(ethylene-vinyl acetate) plastic, with the flat (10), flexible bag (10) being stretched in a dir ection normal to the path of ultraviolet radiation. Novel irradiating devices (40) are also disclosed.
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公开(公告)号：AU3720097A
公开(公告)日：1998-02-09
申请号：AU3720097
申请日：1997-07-10
Applicant: BAXTER INT
Inventor： DELMOTTE YVES , BILSTAD ARNOLD , AMRANI DAVID , KENNEDY MARK , DIORIO JAMES
Abstract: This invention provides a medical device for delivering volumetric quantities of a first and a second biochemically reactive fluid comprising a first container having an opening, the first container being adapted to contain the first biochemically reactive fluid; a second container having a second fluid opening adjacent the first fluid opening, the second container being adapted to contain the second biochemically reactive fluid; a spray unit for separately atomizing the first and second biochemically reactive fluids into an aerosol with at least one energy source of a liquid energy, a mechanical energy, a vibration energy, and an electric energy; a fluid pressurizer for pressurizing the first and the second biochemically reactive fluids for delivery under pressure through the spray unit onto a surface; and wherein the first and second biochemically reactive fluids first mix on the surface.
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公开(公告)号：DE68923081T2
公开(公告)日：1996-03-07
申请号：DE68923081
申请日：1989-09-05
Applicant: BAXTER INT
Inventor： BACEHOWSKI DAVID , BILSTAD ARNOLD , FISHER DAVID , GLINIECKI ROBERT , KEILMAN MICHAEL , SMITH SIDNEY
Abstract: A cell culture media container is provided. The container comprises a body constructed from flexible film and defining a containment area for containing the cell culture media, the body including a front face and a back face, the front and back face being sealed to each other along at least three sides thereof. The container includes a fill port for filling the containment area with cell culture media, the port being sealed to a face of the body and being so constructed and arranged that it extends from the face normal thereto. The container is constructed from a high barrier, optically clear, radiation sterilizable film.
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公开(公告)号：CA2031522A1
公开(公告)日：1990-11-03
申请号：CA2031522
申请日：1990-01-17
Applicant: BAXTER INT
Inventor： MIRIPOL JEFFREY E , BILSTAD ARNOLD , FOLEY JOHN , GLASH DEAN , BRATTEN WILLIAM R
Abstract: A thin film or layer of white blood cells, such as the contaminating white cells in a platelet concentrate, is irradiated with ultraviolet radiation predominately of a wavelength of 280 to 320 nanometers, and preferably at an intensity of 4 to 20 milliwatts per square cm. to provide a total energy exposure of typically 800 to 20,000 millijoules per square cm. of ultraviolet radiation. The white blood cells so produced substantially lose their capability to set off an immune reaction in an alloimmunized patient. The white blood cells may preferably be placed into such film in a flat, flexible bag made of poly(ethylene-vinyl acetate) plastic, with the flat, flexible bag being stretched in a direction normal to the path of ultraviolet radiation. Novel irradiating devices are also disclosed.
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