公开(公告)号：WO03033066A3

公开(公告)日：2003-07-31

申请号：PCT/US0231316

申请日：2002-10-02

Applicant: BAXTER INT

Inventor： VANDLIK MARK R ,  KAST MICHAEL J ,  SMITH KELLY B

IPC: A61M1/02 ,  A61M1/10 ,  A61M1/30 ,  A61M1/36 ,  A61M37/00 ,  B01D33/15 ,  C02F1/00

CPC classification number: A61M1/3696 ,  A61M1/0209 ,  A61M1/0218 ,  A61M1/1006 ,  A61M1/1037 ,  A61M1/1062 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3633 ,  A61M1/3636 ,  A61M1/3693 ,  A61M2205/12 ,  A61M2205/128 ,  A61M2205/331 ,  A61M2205/3393

Abstract: Systems and methods separate blood cells from whole blood and pump the separated blood cells through an in-line leukofilter to a blood cell storage container. The leukofilter comprises a filtration medium enclosed within a flexible housing. The systems and methods include a fixture to restrain expansion of the flexible filter housing during operation of the pump. The fixture includes a bracket to enable its releasable attachment to the blood processing device employed to carry out the separation process.

Abstract translation: 系统和方法将血液细胞与全血分离，并将分离的血液细胞通过直列式白细胞滤器泵送至血细胞储存容器。 白细胞滤器包括封装在柔性壳体内的过滤介质。 该系统和方法包括在泵的操作期间抑制柔性过滤器壳体的膨胀的夹具。 固定装置包括支架，以使其能够可释放地附接到用于执行分离过程的血液处理装置。

公开(公告)号：EP0695200A4

公开(公告)日：1997-06-18

申请号：EP94920648

申请日：1994-03-17

Applicant: BAXTER INT

Inventor： GIESLER RICHARD C ,  ELLIS DALE R ,  VANDLIK MARK R

IPC: A61M5/168 ,  A61M1/36 ,  A61M5/14 ,  A61M5/00

CPC classification number: A61M5/1411 ,  A61M1/30 ,  A61M1/303 ,  A61M1/3627 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2005/1403 ,  A61M2205/12

Abstract: A drip chamber (506) includes a cap (510) that extends the field of view of a droplet in a vertical direction above the plane of the droplet, as well as horizontally in the plane of the droplet. The drip chamber has a deformable body and an interior volume to accommodate manual air purging and priming by squeezing the body.

公开(公告)号：EP1251922A4

公开(公告)日：2010-02-24

申请号：EP01994172

申请日：2001-11-13

Applicant: BAXTER INT

Inventor： ODAK SANJAY V ,  VANDLIK MARK R ,  WESTBERG TOM

IPC: A61M1/02 ,  B01D17/12 ,  A61M1/26 ,  A61M1/36 ,  A61M1/38 ,  B01D17/02

CPC classification number: A61M1/3693 ,  A61M1/0218 ,  A61M1/262 ,  A61M1/265 ,  A61M1/3696 ,  A61M1/38 ,  A61M2205/125 ,  A61M2205/126 ,  A61M2205/128 ,  A61M2205/6063 ,  A61M2230/207 ,  B01D17/0217 ,  B01D17/085

Abstract: A pneumatic pump manifold disposable system, configured as a cassette, is used for the purpose of red cell and plasma apheresis. The cassette integrates a separation device, manifold system, macro-aggregate filter, and five pumping chambers for the purpose of separating plasma and red cells from the whole blood. The cassette system, with the separation device directly attached without tubing, simplifies the loading of the disposable set into the hardware, and reduces the manufacturing complexity of the set. The system allows for plasma, plasma and red cells, or just red cells to be stored in long term storage containers after a procedure.

Abstract translation: 配置为盒式的气动泵歧管一次性系统用于红细胞和血浆匀浆。 该盒集成了分离装置，歧管系统，大聚集体过滤器和五个泵送室，用于从全血中分离血浆和红细胞。 带有分离装置的盒式系统直接连接无管，简化了一次性装置进入硬件的装载，降低了组件的制造复杂度。 该系统允许血浆，血浆和红细胞，或只是红细胞在手术后储存在长期储存容器中。

公开(公告)号：EP1434619A4

公开(公告)日：2009-10-28

申请号：EP02766453

申请日：2002-10-02

Applicant: BAXTER INT

Inventor： VANDLIK MARK R ,  KAST MICHAEL J ,  SMITH KELLY B

IPC: A61M1/02 ,  A61M1/10 ,  A61M1/30 ,  A61M1/36

CPC classification number: A61M1/3696 ,  A61M1/0209 ,  A61M1/0218 ,  A61M1/1006 ,  A61M1/1037 ,  A61M1/1062 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3633 ,  A61M1/3636 ,  A61M1/3693 ,  A61M2205/12 ,  A61M2205/128 ,  A61M2205/331 ,  A61M2205/3393

公开(公告)号：EP1128887A4

公开(公告)日：2004-09-08

申请号：EP00961406

申请日：2000-08-29

Applicant: BAXTER INT

Inventor： VISHNOI ROHIT ,  WESTBERG TOM ,  MULLER MATTHEW R ,  SMITH KELLY B ,  JOIE MICHEL L F ,  VANDLIK MARK R

IPC: G01N33/48 ,  A61M1/02 ,  A61M1/34 ,  A61M1/36 ,  B01D17/02 ,  B01D21/24 ,  B04B5/00 ,  G01N21/27 ,  G01N21/35 ,  G01N33/483 ,  G01N33/49 ,  B04B5/04

CPC classification number: B01D21/34 ,  A61M1/0236 ,  A61M1/3496 ,  A61M1/3646 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0415 ,  A61M2202/0429 ,  A61M2205/125 ,  A61M2205/128 ,  A61M2205/331 ,  A61M2205/3393 ,  B01D17/0217 ,  B01D21/2444 ,  B01D21/245 ,  B01D21/26 ,  B01D21/262 ,  B01D21/302 ,  B01D2221/08 ,  B01D2221/10

Abstract: A blood separation system (10) is described. The system comprises a device (14, 18) which, in use, operates to separate whole blood into red blood cells and plasma, a whole blood inlet line (290) for conveying a flow of whole blood into the device, a plasma collection line (292) for conveying a flow of plasma from the device, and a red blood cell collection line (294) for conveying a flow of red blood cells from the device. A first sensing assembly (334) including a first sensor in the plasma collection line is provided which in use operates to detect a characteristic of plasma in the flow of plasma and to generate a first output. A second sensing assembly (336) including a second sensor in the red blood cell collection line is provided which in use operates to detect a characteristic of red blood cells in the flow of red blood cells and to generate a second output. A controller (16) operates to control flows in the plasma collection line and the red blood cell collection line based upon the first and second outputs.

Abstract translation: 描述血液分离系统（10）。 该系统包括在使用中操作以将全血分离成红细胞和血浆的装置（14,18），用于将全血流输送到装置中的全血入口管线（290），等离子体收集管线 （292），用于输送来自所述装置的等离子体流;以及红细胞收集线（294），用于从所述装置传送红细胞流。 提供了包括等离子体收集线中的第一传感器的第一检测组件（334），其在使用中操作以检测等离子体流中的等离子体的特性并产生第一输出。 提供了包括红细胞收集线中的第二传感器的第二检测组件（336），其在使用中操作以检测红细胞流中的红细胞的特征并产生第二输出。 控制器（16）操作以基于第一和第二输出来控制血浆收集线和红细胞收集线中的流动。

公开(公告)号：EP1126896A4

公开(公告)日：2004-08-04

申请号：EP00961403

申请日：2000-08-29

Applicant: BAXTER INT

Inventor： WESTBERG TOM ,  VISHNOI ROHIT ,  VANDLIK MARK R

IPC: A61M1/02 ,  A61M1/10 ,  A61M1/30 ,  A61M1/36 ,  A61M37/00 ,  B01D37/00 ,  B01D61/00 ,  B01D63/00 ,  C02F1/00 ,  C02F1/44 ,  F04B9/08 ,  F04B17/00 ,  F04B35/00 ,  F04B49/00

CPC classification number: A61M1/3693 ,  A61M1/0218 ,  A61M1/1006 ,  A61M1/1037 ,  A61M1/1062 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3633 ,  A61M1/3636 ,  A61M1/3696 ,  A61M2205/128 ,  A61M2205/331 ,  A61M2205/3393

Abstract: A multiple function pump station (PPN) performs different on-line processing tasks. The pump station can be operated in one mode to draw blood from a donor and can in another mode be operated to return blood to the donor. The pump station used to draw blood from a donor can also be used to perform subsequent blood processing tasks, such as mixing processing or additive fluids with the blood, or transferring a harvested blood component to a storage container, or finishing the processing of a harvested blood component, e.g., by passage through a filter (200) to remove leukocytes.

公开(公告)号：EP0914048A4

公开(公告)日：2001-04-04

申请号：EP97954131

申请日：1997-12-11

Applicant: BAXTER INT

Inventor： KANDLER JAMES J ,  MOUBAYED AHMAD-MAHER ,  VANDLIK MARK R

IPC: A61B5/15 ,  A61M1/02 ,  A61M1/30 ,  A61M5/14 ,  A44B21/00 ,  F04B43/12

CPC classification number: A61M1/30 ,  A61M1/303 ,  A61M1/38 ,  A61M5/1418 ,  Y10T24/44034

Abstract: A disposable tubing set (10) having an array of flexible tubing and a method for holding an array of flexible tubing. The disposable tubing set has a frame (36) for holding segments (38) of the tubing. The frame (36) includes at least two sides and a plurality of apertures defined in the sides. Segments (38) of the tubing extend through and are completely enclosed by the apertures.

公开(公告)号：CA2347618C

公开(公告)日：2010-02-23

申请号：CA2347618

申请日：2000-08-29

Applicant: BAXTER INT

Inventor： VISHNOI ROHIT ,  WESTBERG TOM ,  MULLER MATTHEW R ,  SMITH KELLY B ,  JOIE MICHEL L F ,  VANDLIK MARK R

IPC: A61M1/02 ,  G01N33/48 ,  A61M1/34 ,  A61M1/36 ,  A61M1/38 ,  B01D17/02 ,  B01D21/24 ,  B01D21/26 ,  B04B5/00 ,  G01N21/27 ,  G01N21/35 ,  G01N21/59 ,  G01N33/483 ,  G01N33/49

Abstract: Blood processing systems and methods employ two sensors (334, 336), one (334) to detect a condition of plasma exiting a separation device (18) and another sensor (336) to detect a condition of a cellular component exiting the separation device (18). The first sensor (334) detects, e.g., contamination of the plasma due to the presence of unwanted cellular components. The second sensor (336) detects, e.g., dilution of the cellular component due to presence of plasma. Blood processing parameters are carried out based, at least in part, by conditions detected by one or both of the sensors (334, 336).

公开(公告)号：AU776741B2

公开(公告)日：2004-09-23

申请号：AU7576200

申请日：2000-08-29

Applicant: BAXTER INT

Inventor： WESTBERG TOM ,  VISHNOI ROHIT ,  VANDLIK MARK R

IPC: F04B9/123 ,  A61B5/15 ,  A61M1/02 ,  A61M1/10 ,  A61M1/30 ,  A61M1/36 ,  F04B13/02 ,  F04B43/02 ,  F04B43/06 ,  F04B49/06 ,  F04B49/00

Abstract: Programmable, fluid pressure actuated blood processing systems (10) and methods are used in association with a blood separation device (18). The systems and methods employ a cassette (28), which contains several preformed, pneumatically actuated pump stations (PP1-PP4), several preformed fluid flow paths (F1-F38), and several preformed, pneumatically actuated (VA1-VA23) valves (1-23) in the fluid flow paths. The systems and methods also employ progr ammable pneumatic actuators (PA1-PA4) to hold the cassette and selectively apply pneumatic force to the valves and the pump stations.

公开(公告)号：AU775852B2

公开(公告)日：2004-08-19

申请号：AU7336200

申请日：2000-08-29

Applicant: BAXTER INT

Inventor： VISHNOI ROHIT ,  WESTBERG TOM ,  MULLER MATTHEW R ,  SMITH KELLY B ,  JOIE MICHEL L F ,  VANDLIK MARK R

IPC: G01N33/48 ,  A61M1/02 ,  A61M1/34 ,  A61M1/36 ,  B01D17/02 ,  B01D21/24 ,  B04B5/00 ,  G01N21/27 ,  G01N21/35 ,  G01N33/483 ,  G01N33/49 ,  B01D21/26 ,  A61M1/38

Abstract: A blood separation system (10) is described. The system comprises a device (14, 18) which, in use, operates to separate whole blood into red blood cells and plasma, a whole blood inlet line (290) for conveying a flow of whole blood into the device, a plasma collection line (292) for conveying a flow of plasma from the device, and a red blood cell collection line (294) for conveying a flow of red blood cells from the device. A first sensing assembly (334) including a first sensor in the plasma collection line is provided which in use operates to detect a characteristic of plasma in the flow of plasma and to generate a first output. A second sensing assembly (336) including a second sensor in the red blood cell collection line is provided which in use operates to detect a characteristic of red blood cells in the flow of red blood cells and to generate a second output. A controller (16) operates to control flows in the plasma collection line and the red blood cell collection line based upon the first and second outputs.