公开(公告)号：WO1996036296A1

公开(公告)日：1996-11-21

申请号：PCT/US1996006826

申请日：1996-05-13

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  PAULEY, Robin, G. ,  McLARTY, Donna, L. ,  KHARE, Atul, R. ,  STERNBERG, Shmuel ,  BOGGS, Daniel, R. ,  NEUENFELDT, Steven ,  JONES, Mark ,  BRAUKER, James, H. ,  MARTINSON, Laura, A.

IPC: A61F02/02

CPC classification number: A61K9/0024 ,  A61F2/022 ,  A61L27/38

Abstract: A permeable structure (16) forms a chamber (12) to hold living cells (14). The structure includes a first permeable region (18) surrounding at least a portion of the chamber (12) having a confirmation that, when implanted is host tissue, substantially blocks penetration of host cells into the chamber (12) while permitting solute transport. The structure (16) also includes a second permeable region (20) overlaying the first permeable region (18) having a confirmation that, when implanted in host tissue, forms a permeable interface with host tissue that permits solute transport. A third permeable region (22) is located between the first (18) and second (20) permeable regions. The third region (22) comprises a solution of polymer material formed in place between the first (18) and second (20) permeable regions. The third permeable region (22) bonds the first (18) and second (20) permeable regions together. The third permeable region (22) also has a confirmation that, when implanted in host tissue, permits solute transport between the first (18) and second (20) permeable regions together, providing a robust, laminated structure that resists delamination during implantation caused by cellular infiltration into discontinuous spaces between the first (18) and second (20) regions. The third, formed-in-place region (22) can also have a confirmation providing an immunoisolation effect. Furthermore, the permeability of the third, formed-in-place membrane (22) is sufficient high that it does not adversely effect the permability value desired for the overall multiple layer structure (16).

Abstract translation: 可渗透结构（16）形成容纳活细胞（14）的腔室（12）。 该结构包括围绕腔室（12）的至少一部分的第一可渗透区域（18），其确认当植入的是宿主组织时，基本上阻止宿主细胞渗入腔室（12），同时允许溶质运输。 结构（16）还包括覆盖第一可渗透区域（18）的第二可渗透区域（20），其确认当植入宿主组织时，与允许溶质运输的宿主组织形成可渗透界面。 第三可渗透区域（22）位于第一（18）和第二（20）可渗透区域之间。 第三区域（22）包括在第一（18）和第二（20）可渗透区域之间形成的聚合物材料溶液。 第三可渗透区域（22）将第一（18）和第二（20）可渗透区域结合在一起。 第三渗透区域（22）还确认，当植入到宿主组织中时，允许第一（18）和第二（20）可渗透区域之间的溶质传输在一起，提供坚固的层压结构，其抵抗植入期间的分层，由 细胞浸润到第一（18）和第二（20）区域之间的不连续空间。 第三个就地区域（22）也可以具有提供免疫隔离效果的确认。 此外，第三就地形成膜（22）的渗透性足够高，使得其不会对整个多层结构（16）所期望的渗透性值产生不利影响。

公开(公告)号：WO1998002113A1

公开(公告)日：1998-01-22

申请号：PCT/US1997009640

申请日：1997-05-29

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  NEUENFELDT, Steven ,  DAUGIRD, Joanne ,  BRAUKER, James ,  GELLER, Robin, L. ,  FREDERICKSEN, Scott ,  JONES, Mark ,  LOUDOVARIS, Thomas ,  MARYANOV, David ,  SHORS, Stephanie

IPC: A61F02/02

CPC classification number: A61K9/0024 ,  A61F2/0095 ,  A61F2/022 ,  A61L27/36 ,  A61L27/38

Abstract: An implant assembly and methods for loading implant devices which avoids the accidental deposition of transplanted material or other contaminates on the exterior of the device during transportation, storage, and handling are disclosed. The implant assembly of the invention may be used with a large variety of implant devices for implanting a variety of materials such as cells, tissue or other materials into a host. The implant assembly includes an implant device having an elongated port and a first chamber for holding material for implantation and a container with a second chamber for holding the implant device. The container functions to maintain the sterility and protect the physical integrity of the implant device during loading, storage, cryopreservation and transportation and is removed immediately prior to implantation of the device. The container may optionally include liquid media for cellular growth, maintenance, cryostorage, or transportation purposes.

Abstract translation: 公开了一种用于装载植入装置的植入物组件和方法，其避免了在运输，储存和处理期间移植材料或其它污染物意外沉积在装置的外部。 本发明的植入物组件可以与各种各样的植入装置一起使用，用于将诸如细胞，组织或其他材料的各种材料植入宿主体内。 植入物组件包括具有细长端口的植入装置和用于保持用于植入的材料的第一腔室和具有用于保持植入装置的第二腔室的容器。 容器用于维持无菌性并且在加载，储存，冷冻保存和运输期间保护植入物装置的物理完整性，并且在植入植入装置之前立即移除。 容器可以任选地包括用于细胞生长，维持，低温保存或运输目的的液体介质。

公开(公告)号：EP0910308A1

公开(公告)日：1999-04-28

申请号：EP97927972.0

申请日：1997-05-29

Applicant: BAXTER INTERNATIONAL INC.

Inventor： NEUENFELDT, Steven ,  DAUGIRD, Joanne ,  BRAUKER, James ,  GELLER, Robin, L. ,  FREDERICKSEN, Scott ,  JONES, Mark ,  LOUDOVARIS, Thomas ,  MARYANOV, David ,  SHORS, Stephanie

IPC: A61L27 ,  A61F2 ,  A61K9

CPC classification number: A61K9/0024 ,  A61F2/0095 ,  A61F2/022 ,  A61L27/36 ,  A61L27/38

Abstract: An implant assembly and methods for loading implant devices which avoids the accidental deposition of transplanted material or other contaminates on the exterior of the device during transportation, storage, and handling are disclosed. The implant assembly of the invention may be used with a large variety of implant devices for implanting a variety of materials such as cells, tissue or other materials into a host. The implant assembly includes an implant device having an elongated port and a first chamber for holding material for implantation and a container with a second chamber for holding the implant device. The container functions to maintain the sterility and protect the physical integrity of the implant device during loading, storage, cryopreservation and transportation and is removed immediately prior to implantation of the device. The container may optionally include liquid media for cellular growth, maintenance, cryostorage, or transportation purposes.