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    2.
    发明专利
    未知

    公开(公告)号：ES2185671T3

    公开(公告)日：2003-05-01

    申请号：ES95101909

    申请日：1995-02-13

    Applicant: BAYER AG

    Inventor： JESCHKE PETER DR ,  HARDER ACHIM DR DR ,  MENCKE NORBERT DR ,  KLEINKAUF HORST PROF DR ,  ZOCHER RAINER DR

    IPC: A01N43/72 ,  A61K31/395 ,  A61K38/00 ,  A61K38/15 ,  A61P33/00 ,  A61P33/10 ,  C07C229/12 ,  C07C229/14 ,  C07C235/12 ,  C07C271/22 ,  C07D273/00 ,  C07K11/02 ,  C12P17/14 ,  C12P21/04

    Abstract: Prodn. of lactic-acid-contg, optically active, cyclic depsipeptides with 18 ring atoms with the aid of a Fusarium fungus or an enzyme prepn. isolated from such a fungus is new. Also claimed is the prodn. of lactic-acid-contg. optically active, cyclic depsipeptides with 18 ring atoms (enniatins)of formula (I) from optically active amino acids of formula (II)-(IV), optically active or racemic alpha -hydroxy acids of formula (V) and (VI) and optically active or racemic lactic acid, where the reaction is effected in the presence of a Fusarium fungus in a nutrient medium or in the presence of a microbial synthetase in a buffer system: R1,R2 and R4 = H, 1-8C alkyl, hydroxyalkyl, mercaptoalkyl, alkylthioalkyl, alkylsulphinylalkyl, alkylsulphonylalkyl, carboxyalkyl, alkoxycarbonylalkyl, carbamoylalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, guanidinoalkyl, 2-6C alkenyl, 3-8C cycloalkyl, or aralkyl or heteroarylalkyl opt. substd. by halogen, OH, alkoxy, alkyl, NO2 or NH2; R3 and R5 = H, 1-8C alkyl, hydroxyalkyl, mercaptoalkyl, alkylthioalkyl, alkylsulphinylalkyl, alkylsulphonylalkyl, 2-6C alkenyl, 3-8C cycloalkyl, or aralkyl or heteroarylalkyl opt. substd. by halogen, OH, alkoxy, alkyl, NO2 or NH2.

    4.
    发明专利
    未知

    公开(公告)号：DE19800400A1

    公开(公告)日：1999-07-15

    申请号：DE19800400

    申请日：1998-01-08

    Applicant: BAYER AG

    Inventor： WAGNER KLAUS DR ,  ERDELEN CHRISTOPH DR ,  ANDERSCH WOLFRAM DR ,  WACHENDORFF-NEUMANN ULRIKE DR ,  TURBERG ANDREAS DR ,  MENCKE NORBERT DR

    IPC: A01N43/50 ,  A01N43/78 ,  A01N47/40 ,  A01N51/00 ,  C07D401/06 ,  C07D417/06 ,  A61K31/41

    Abstract: The present invention relates to novel guanidine derivatives of formula (1), wherein R represents a five or six membered heterocyclic group containing 1, 2, 3 or 4 nitrogen atoms and/or one or two oxygen or sulphur atoms as heteroatom ring members, whereby the number of heteroatoms is 1, 2, 3 or 4 and is optionally substituted by halogen, cyano, nitro, alkyl, halogen alkane, alkenyl, halogen alkenyl, alkinyl, alkoxy, halogen alkoxy, alkenyloxy, halogen alkenyloxy, alkinyloxy, alkylthio, halogen alkanethio, alkenylthio, halogen alkenylthio, alkinylthio, alkylsulphinyl, halogen alkanesulphinyl, alkylsulphonyl, amino, alkylamino, dialkylamino, aryl, arylthio, arylamino, aralkyl, formylamino, alkylcarbonylamino, formyl, carbamoyl, alkylcarbonyl and or alkoxycarbonyl, R represents hydrogen or alkyl, R represents groups -OCR , -OCOR , OCOOR , OCONR R and -OSO R , whereby R and R represent independently of each other alkyl, alkoxyalkyl, halogen alkane, alkenyl, alkinyl, alkylaminoalkyl, dialkylaminoalkyl, optionally substituted cycloalkyl and optionally substituted phenyl or benzyl, R and R represent independently of each other hydrogen, alkyl, alkenyl and optionally substituted phenyl or benzyl and R represents alkyl or optionally substituted pheyl, A represents groups -CH2CH2-, (CH2)3 and -CH=CH- and Z represents cyano or nitro, with the proviso that when Z represents NO2 and A represents -CH2CH2, the radical R represents hydrogen and the compound of formula (1), wherein R corresponds to formula (II), R = H, R = OCH3, A = -CH2CH2- and Z = NO2, is excluded.

    7.
    发明专利
    未知

    公开(公告)号：BR9608961A

    公开(公告)日：1999-06-29

    申请号：BR9608961

    申请日：1996-05-20

    Applicant: BAYER AG

    Inventor： MENCKE NORBERT DR ,  HARDER ACHIM DR ,  JESCHKE PETER DR ,  HELPAP BARBARA DE

    IPC: C07D273/00 ,  A61K31/395 ,  A61K38/15 ,  A61P33/00 ,  A61P33/10 ,  C07D493/22

    Abstract: PCT No. PCT/EP96/02170 Sec. 371 Date Nov. 19, 1997 Sec. 102(e) Date Nov. 19, 1997 PCT Filed May 20, 1996 PCT Pub. No. WO96/38165 PCT Pub. Date Dec. 5, 1996The present invention relates to mixtures of avermectins, 22,23-dihydroavermectins B1 (ivermectins) and milbemycins from the class of the macrocyclic lactones in combination with cyclic depsipeptides, optionally in the presence of praziquantel or epsiprantel, for increasing the endoparasiticidal action in endoparasiticidal compositions.

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