公开(公告)号：AT218555T

公开(公告)日：2002-06-15

申请号：AT94107543

申请日：1994-05-16

Applicant: BAYER AG

Inventor： SCHERKENBECK JUERGEN DR ,  JESCHKE PETER DR ,  LERCHEN HANS-GEORG DR ,  HAGEMANN HERMANN DR ,  HARDER ACHIM DR DR ,  MENCKE NORBERT DR ,  PLANT ANDREW DR

IPC: A01N43/72 ,  A61K31/395 ,  A61K38/00 ,  A61P33/10 ,  C07C235/12 ,  C07C235/34 ,  C07D273/00 ,  C07K1/113 ,  C07K11/00 ,  C07K11/02

Abstract: The present invention relates to compounds of the general formula (I) in which R , R , R and R are identical or different radicals of the group consisting of C1-8-alkyl, C1-8-haloalkyl, C3-6-cycloalkyl, aralkyl and aryl, and their stereoisomers, processes for their preparation and their use as endoparasiticides.

公开(公告)号：DE59408240D1

公开(公告)日：1999-06-17

申请号：DE59408240

申请日：1994-11-28

Applicant: BAYER AG

Inventor： SCHERKENBECK JUERGEN DR ,  JESCHKE PETER DR ,  PLANT ANDREW DR ,  HARDER ACHIM DR ,  MENCKE NORBERT DR

IPC: A61K31/22 ,  A61K38/15 ,  A61P33/10 ,  C07K7/06

公开(公告)号：DE19648011A1

公开(公告)日：1998-05-28

申请号：DE19648011

申请日：1996-11-20

Applicant: BAYER AG

Inventor： PLANT ANDREW DR ,  KLEEFELD GERD DR ,  POETTER THORSTEN DR ,  ERDELEN CHRISTOPH DR ,  MENCKE NORBERT DR ,  TURBERG ANDREAS DR ,  WACHENDORFF-NEUMANN ULRIKE DR

IPC: C12N15/09 ,  A01N43/34 ,  A01N43/36 ,  A61K38/00 ,  A61P31/12 ,  A61P31/14 ,  C07C205/04 ,  C07C205/45 ,  C07C271/18 ,  C07D207/12 ,  C07D207/20 ,  C07D211/70 ,  C07D223/04 ,  C07D227/04 ,  C07D405/10 ,  C07D407/10 ,  C07D409/10 ,  C07K7/06 ,  C07D207/26

Abstract: The invention relates to novel cyclic imines of formula (I) wherein Ar , Ar mean in each case substituted phenyl and n is 1,2 or 3; several methods for the production and the use thereof as pesticides.

公开(公告)号：DE59501795D1

公开(公告)日：1998-05-14

申请号：DE59501795

申请日：1995-01-09

Applicant: BAYER AG

Inventor： SCHERKENBECK JUERGEN DR ,  JESCHKE PETER DR ,  PLANT ANDREW DR ,  HARDER ACHIM DR ,  MENCKE NORBERT DR

IPC: A61K31/33 ,  A61K31/365 ,  A61K31/38 ,  A61K31/41 ,  A61K38/00 ,  A61P33/00 ,  A61P33/10 ,  C07D273/00 ,  C07D273/08 ,  C07D413/06 ,  C07K11/02

Abstract: Control of endoparasites in human beings and animals comprises admin. of cyclic depsipeptide of formula (I); R ,R = H or opt. substd. alkyl, cycloalkyl, aralkyl, aryl, heteroaryl or heteroarylalkyl; R ,R ,R ,R = H; 1-8C alkyl; haloalkyl; HO-alkyl; alkanoylalkyl; alkoxyalkyl; aryloxyalkyl; HS-alkyl; alkylthioalkyl; alkylsulphinylalkyl; alkylsulphonylalkyl; COOH-alkyl; alkoxycarbonylalkyl; arylalkoxycarbonylalkyl; carbamoylalkyl; H2N-alkyl opt. N-mono- or N,N-di-substd. by alkyl; guanidinoalkyl opt. mono- or di-substd. by BzO-CO- or mono- to tetra-substd. by alkyl; alkoxycarbonylaminoalkyl; Fmoc-aminoalkyl; alkenyl; cycloalkyl; cycloalkylalkyl; or opt. substd. aryl, aralkyl, heteroaryl or heteroarylalkyl. Known cpds. (I) are described in J.A.C.S. 91(1969), p. 4888; Biorg. Khim. 1 (1975), 375; Biofizica 16 (1971) p. 407; and lav. Akad. Nark. SCSR, Set Khim, 1970, p. 991. (I) have good mammalian toxicity and can be used to control pathogenic endoparasites such as cestodes, trematodes, nematodes and acantocephales, e.g. Taenia, Dactylogyrus, Schistosoma, Fasciola, Trichomosoides, Strondyloides, Filaroides, Enterobius and Toxocara spp. (I) are pref. used in veterinary medicine to treat e.g. domestic pets, farm, zoo and laboratory animals, poultry, fish and insects such as honey bees and silkworms. (I) can also be used therapeutically or prophylactically in the form of conventional formulations, e.g. powders, tablets or medicated feed, and may be administered by the enteral, parenteral, nasal or transdermal route. (I) are more active in controlling worm diseases than prior art cpds.

公开(公告)号：DE59408242D1

公开(公告)日：1999-06-17

申请号：DE59408242

申请日：1994-11-28

Applicant: BAYER AG

Inventor： JESCHKE PETER DR ,  SCHERKENBECK JUERGEN DR ,  PLANT ANDREW DR ,  HARDER ACHIM DR ,  MENCKE NORBERT DR

IPC: A61K31/22 ,  A61K38/15 ,  A61P33/10 ,  C07K11/00

公开(公告)号：DE19529604A1

公开(公告)日：1997-02-13

申请号：DE19529604

申请日：1995-08-11

Applicant: BAYER AG

Inventor： JESCHKE PETER DR ,  SCHERKENBECK JUERGEN DR ,  PLANT ANDREW DR ,  HARDER ACHIM DR DR ,  MENCKE NORBERT DR

IPC: C07D295/18 ,  A01N47/10 ,  A01N47/28 ,  A61K31/00 ,  A61K31/215 ,  A61K31/357 ,  A61K31/36 ,  A61K31/395 ,  A61K31/40 ,  A61K31/425 ,  A61K31/426 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/4453 ,  A61K31/4465 ,  A61K31/4468 ,  A61K31/451 ,  A61K31/495 ,  A61K31/496 ,  A61K31/50 ,  A61K31/501 ,  A61K31/505 ,  A61K31/506 ,  A61K31/535 ,  A61K31/5375 ,  A61K31/54 ,  A61K31/541 ,  A61K31/55 ,  A61P33/00 ,  A61P33/02 ,  C07C271/22 ,  C07C271/54 ,  C07C275/16 ,  C07C275/50 ,  C07C275/62 ,  C07C333/04 ,  C07D207/16 ,  C07D211/42 ,  C07D211/44 ,  C07D211/58 ,  C07D211/60 ,  C07D211/64 ,  C07D211/70 ,  C07D211/74 ,  C07D213/40 ,  C07D213/61 ,  C07D213/74 ,  C07D213/79 ,  C07D239/42 ,  C07D241/18 ,  C07D265/30 ,  C07D277/06 ,  C07D277/20 ,  C07D277/32 ,  C07D277/46 ,  C07D295/185 ,  C07D295/20 ,  C07D295/215 ,  C07D295/22 ,  C07D317/58 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12 ,  C07K11/00 ,  A01N37/44 ,  A01N43/34

Abstract: The use is disclosed of didepsipeptides having the general formula (I) and their salts, as well as new didepsipeptides and a process for preparing the same. In the formula (I), the rests have the meanings given in the description.

公开(公告)号：DE4341992A1

公开(公告)日：1995-06-14

申请号：DE4341992

申请日：1993-12-09

Applicant: BAYER AG

Inventor： SCHERKENBECK JUERGEN DR ,  JESCHKE PETER DR ,  PLANT ANDREW DR ,  HARDER ACHIM DIPL BIOL DR ,  MENCKE NORBERT DR

IPC: A61K31/22 ,  A61K38/15 ,  A61P33/10 ,  C07C235/12 ,  C07C235/34 ,  C07K11/00

Abstract: The present invention relates to the use of open-chain tetradepsipeptides of the general formula (I) and their optical isomers and racemates, for controlling endoparasites in human and veterinary medicine.

公开(公告)号：CS314991A3

公开(公告)日：1992-05-13

申请号：CS314991

申请日：1991-10-17

Applicant: BAYER AG

Inventor： BERTRAM HEINZ-JURGEN DR ,  LURSSEN KLAUS DR ,  SANTEL HANS-JOACHIM DR ,  SCHMIDT ROBERT R DR ,  PLANT ANDREW DR ,  KRUGER BERND-WIELAND DR ,  HARDER ACHIM DR ,  MENCKE NORBERT DR

IPC: A01N43/90 ,  C07D333/32 ,  C07D333/78 ,  C07D339/08 ,  C07D495/04 ,  A61K31/38

Abstract: Novel substituted thieno[3,2-b]pyran-5,7-diones of the general formula (I) (I) Processes for their preparation and their use as herbicides and as plant growth regulators and novel intermediates of the formula (VI) (VI) (in which R1, R2, X, Y and Z have the meaning given in the description).

公开(公告)号：DE4111652A1

公开(公告)日：1992-04-30

申请号：DE4111652

申请日：1991-04-10

Applicant: BAYER AG

Inventor： BERTRAM HEINZ-JUERGEN DR ,  LUERSSEN KLAUS DR ,  SANTEL JOACHIM DR ,  SCHMIDT ROBERT-R DR ,  PLANT ANDREW DR ,  KRUEGER BERND-WIELAND DR ,  HARDER ACHIM DR ,  MENCKE NORBERT DR

IPC: A01N43/90 ,  C07D333/32 ,  C07D333/78 ,  C07D339/08 ,  C07D495/04

Abstract: Novel substituted thieno[3,2-b]pyran-5,7-diones of the general formula (I) (I) Processes for their preparation and their use as herbicides and as plant growth regulators and novel intermediates of the formula (VI) (VI) (in which R1, R2, X, Y and Z have the meaning given in the description).

公开(公告)号：ES2115269T3

公开(公告)日：1998-06-16

申请号：ES95100198

申请日：1995-01-09

Applicant: BAYER AG

Inventor： SCHERKENBECK JURGEN DR ,  JESCHKE PETER DR ,  PLANT ANDREW DR ,  HARDER ACHIM DR ,  MENCKE NORBERT DR

IPC: A61K31/33 ,  A61K31/365 ,  A61K31/38 ,  A61K31/41 ,  A61K38/00 ,  A61P33/00 ,  A61P33/10 ,  C07D273/00 ,  C07D273/08 ,  C07D413/06 ,  C07K11/02

Abstract: Control of endoparasites in human beings and animals comprises admin. of cyclic depsipeptide of formula (I); R ,R = H or opt. substd. alkyl, cycloalkyl, aralkyl, aryl, heteroaryl or heteroarylalkyl; R ,R ,R ,R = H; 1-8C alkyl; haloalkyl; HO-alkyl; alkanoylalkyl; alkoxyalkyl; aryloxyalkyl; HS-alkyl; alkylthioalkyl; alkylsulphinylalkyl; alkylsulphonylalkyl; COOH-alkyl; alkoxycarbonylalkyl; arylalkoxycarbonylalkyl; carbamoylalkyl; H2N-alkyl opt. N-mono- or N,N-di-substd. by alkyl; guanidinoalkyl opt. mono- or di-substd. by BzO-CO- or mono- to tetra-substd. by alkyl; alkoxycarbonylaminoalkyl; Fmoc-aminoalkyl; alkenyl; cycloalkyl; cycloalkylalkyl; or opt. substd. aryl, aralkyl, heteroaryl or heteroarylalkyl. Known cpds. (I) are described in J.A.C.S. 91(1969), p. 4888; Biorg. Khim. 1 (1975), 375; Biofizica 16 (1971) p. 407; and lav. Akad. Nark. SCSR, Set Khim, 1970, p. 991. (I) have good mammalian toxicity and can be used to control pathogenic endoparasites such as cestodes, trematodes, nematodes and acantocephales, e.g. Taenia, Dactylogyrus, Schistosoma, Fasciola, Trichomosoides, Strondyloides, Filaroides, Enterobius and Toxocara spp. (I) are pref. used in veterinary medicine to treat e.g. domestic pets, farm, zoo and laboratory animals, poultry, fish and insects such as honey bees and silkworms. (I) can also be used therapeutically or prophylactically in the form of conventional formulations, e.g. powders, tablets or medicated feed, and may be administered by the enteral, parenteral, nasal or transdermal route. (I) are more active in controlling worm diseases than prior art cpds.