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公开(公告)号：WO9511912A3
公开(公告)日：1995-06-08
申请号：PCT/US9412437
申请日：1994-10-28
Applicant: BECKMAN INSTRUMENTS INC
Inventor： COASSIN PETER J , MATSON ROBERT S , RAMPAL JANG B
IPC: G01N33/53 , A61K38/00 , A61K39/44 , B01J19/00 , C07H21/00 , C07H21/04 , C07K1/04 , C07K7/06 , C07K7/08 , C08B37/00 , C12N15/09 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B40/12 , G01N33/543 , G01N33/545 , G01N33/566 , G01N37/00
CPC classification number: C07H21/00 , B01J19/0046 , B01J2219/00497 , B01J2219/00527 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , C07K1/042 , C12Q1/6834 , C12Q1/6869 , C40B40/06 , C40B40/10 , C40B40/12 , G01N33/54353 , Y10T436/143333
Abstract: Disclosed herein are surface activated, organic polymers useful for biopolymer synthesis. Most preferably, aminated biaxially oriented polypropylene is used for the synthesis of oligonucleotides thereto, and these devices are most preferably utilized for genetic analysis of patient samples.
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公开(公告)号：AU5325496A
公开(公告)日：1996-10-16
申请号：AU5325496
申请日：1996-03-29
Applicant: BECKMAN INSTRUMENTS INC
Inventor： RAMPAL JANG B , RAMPAL SUSHMA , OSBORNE JAMES C
IPC: G01N27/447
Abstract: A sample having both positively and negatively charged components may be separated during the same run by injecting a plug of sample at both ends of the capillary and applying an electric field in the capillary, where there is insufficient electroosmotic flow in the capillary to reverse sample migration direction, such as in the case of a gel-filled column.
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公开(公告)号：AU6707794A
公开(公告)日：1994-11-08
申请号：AU6707794
申请日：1994-04-19
Applicant: BECKMAN INSTRUMENTS INC
Inventor： COASSIN PETER J , KONRAD KENNETH D , RAMPAL JANG B , COOK RONALD M
IPC: C12N15/09 , C07H21/00 , C07H21/04 , C12N15/10 , C12Q1/68 , C12Q1/6853 , C12Q1/6862 , C12P19/34
Abstract: Inverse Linkage Oligonucleotides ("ILO") useful in enzymatic process are disclosed. Particularly preferred ILOs are amenable to enzymatic elongation from either, or most preferably, both termini. In a particularly preferred embodiment, each terminus of an ILO has an enzymatically functional 3' group. Accordingly, under appropriate conditions and in the presence of, e.g., dNTPs, enzyme, sample DNA, and ILO comprising a first region complementary to a first region of the sample DNA and a second region complementary to a second, different region of the sample DNA, exponential amplification of the sample DNA can be effectuated.
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公开(公告)号：AU671688B2
公开(公告)日：1996-09-05
申请号：AU5294493
申请日：1993-09-28
Applicant: BECKMAN INSTRUMENTS INC
Inventor： COASSIN PETER J , MATSON ROBERT S , RAMPAL JANG B
IPC: C07H21/00 , C08F8/00 , C08F8/32 , C12Q1/68 , C12Q1/6827 , C12Q1/6834 , C07K1/04 , C08F8/30 , C07H3/00 , C08J7/12
Abstract: Disclosed herein are surface activated, organic polymers useful for biopolymer synthesis. Most preferably, aminated polypropylene is used for the synthesis of oligonucleotides thereto, and these devices are most preferably utilized for genetic analysis of patient samples.
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公开(公告)号：AU2360195A
公开(公告)日：1995-11-29
申请号：AU2360195
申请日：1995-04-24
Applicant: BECKMAN INSTRUMENTS INC , CHARLES THOMAS CASKEY
Inventor： CASKEY CHARLES THOMAS , MATSON ROBERT S , COASSIN PETER J , RAMPAL JANG B
IPC: C12Q1/68 , C12Q1/6827 , C12Q1/6837 , C12Q1/6874
Abstract: A solid support based hybridization assay is provided which allows for the systematic and reproducible analysis of repeat and tandem repeat oligonucleotide sequences of DNA and RNA by hybridization to a reverse dot blot array comprising strings of such repeats complementary to those found in particular nucleic acid targets (e.g., analyte PCR product). An addressable library (i.e., an indexed set) of complementary repeats is synthesized on a suitable support. Preferably, the support comprises a low fluorescent background support, thereby facilitating the use of non-radioisotopic modes of detection (such as fluorescence or chemiluminescence); particularly suitable in this regard is an aminated polypropylene support or similar material. Preferred arrays permit screening of DNA and RNA samples for complete sets of particular types of nucleotide repeat sequences (e.g., all nucleotide doublet or triplet repeats).
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Patent Agency Ranking
公开(公告)号：CA2160799A1
公开(公告)日：1994-10-27
申请号：CA2160799
申请日：1994-04-19
Applicant: BECKMAN INSTRUMENTS INC
Inventor： COASSIN PETER J , KONRAD KENNETH D , RAMPAL JANG B , COOK RONALD M
IPC: C12N15/09 , C07H21/00 , C07H21/04 , C12N15/10 , C12Q1/68 , C12Q1/6853 , C12Q1/6862 , C12P19/34
Abstract: Disclosed herein, inter alia, are Inverse Linkage Oligonucleotides ("ILO") useful in enzymatic process. Particularly preferred ILOs are amenable to enzymatic elongation from either, or most preferably, both termini. In a particularly preferred embodiment, each terminus of an ILO has an enzymatically functional 3' group. Accordingly, under appropriate conditions and in the presence of, e.g., dNTPs, enzyme, sample DNA, and ILO comprising a first region complementary to a first region of the sample DNA and a second region complementary to a second, different region of the sample DNA, exponential amplification of the sample DNA can be effectuated.
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公开(公告)号：WO9509176A1
公开(公告)日：1995-04-06
申请号：PCT/US9309294
申请日：1993-09-28
Applicant: BECKMAN INSTRUMENTS INC
Inventor： COASSIN PETER J , MATSON ROBERT S , RAMPAL JANG B
CPC classification number: C07H21/00 , C08F8/30 , C08F8/32 , C12Q1/6827 , C12Q1/6834 , C08F110/06
Abstract: Disclosed herein are surface activated, organic polymers useful for biopolymer synthesis. Most preferably, aminated polypropylene is used for the synthesis of oligonucleotides thereto, and these devices are most preferably utilized for genetic analysis of patient samples.
Abstract translation: 本文公开了可用于生物聚合物合成的表面活化的有机聚合物。 最优选地，胺化聚丙烯用于合成寡核苷酸，并且这些装置最优选用于患者样品的遗传分析。
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8.发明申请
公开(公告)号：WO9424312A3
公开(公告)日：1994-12-08
申请号：PCT/US9404275
申请日：1994-04-19
Applicant: BECKMAN INSTRUMENTS INC
Inventor： COASSIN PETER J , KONRAD KENNETH D , RAMPAL JANG B , COOK RONALD M
CPC classification number: C07H21/00 , C12N15/1034 , C12Q1/6853 , C12Q1/6862
Abstract: Disclosed herein, inter alia, are Inverse Linkage Oligonucleotides ('ILO') useful in enzymatic process. Particularly preferred ILOs are amenable to enzymatic elongation from either, or most preferably, both termini. In a particularly preferred embodiment, each terminus of an ILO has an enzymatically functional 3' group. Accordingly, under appropriate conditions and in the presence of, e.g., dNTPs, enzyme, sample DNA, and ILO comprising a first region complementary to a first region of the sample DNA and a second region complementary to a second, different region of the sample DNA, exponential amplification of the sample DNA can be effectuated.
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公开(公告)号：AU5294493A
公开(公告)日：1995-04-18
申请号：AU5294493
申请日：1993-09-28
Applicant: BECKMAN INSTRUMENTS INC
Inventor： COASSIN PETER J , MATSON ROBERT S , RAMPAL JANG B
IPC: C07H21/00 , C08F8/00 , C08F8/32 , C12Q1/68 , C12Q1/6827 , C12Q1/6834 , C07K1/04 , G01N33/68 , C08F8/30 , C08J3/28
Abstract: Disclosed herein are surface activated, organic polymers useful for biopolymer synthesis. Most preferably, aminated polypropylene is used for the synthesis of oligonucleotides thereto, and these devices are most preferably utilized for genetic analysis of patient samples.
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公开(公告)号：CA2167589A1
公开(公告)日：1995-04-06
申请号：CA2167589
申请日：1993-09-28
Applicant: BECKMAN INSTRUMENTS INC
Inventor： COASSIN PETER J , MATSON ROBERT S , RAMPAL JANG B
Abstract: Disclosed herein are surface activated, organic polymers useful for biopolymer synthesis. Most preferably, aminated polypropylene is used for the synthesis of oligonucleotides thereto, and these devices are most preferably utilized for genetic analysis of patient samples.
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