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公开(公告)号：JPH10170429A
公开(公告)日：1998-06-26
申请号：JP27694897
申请日：1997-10-09
Applicant: BIO RAD LABORATORIES
Inventor： HEFFELFINGER DAVID M , WITNEY FRANKLIN R , CUNANAN CHRIS
Abstract: PROBLEM TO BE SOLVED: To measure fluorescence, luminescence and an absorption characteristic of a sample at a plurality of positions in a single sample well of a microplate, by setting an arrangement tool for moving a relative position of a sample-fixing tool and a detector. SOLUTION: A radiation from a light source 105 illuminates a sample 101 through an adjustment section 107 and an optical component 109. A fluorescence and/or a luminescence from the sample 101 forms an image on a detector 111 through an optical component 113 and an adjustment section 115. A second detector 117 is arranged below the sample 101 and used for the measurement of absorption. A fixing tool 103 is connected to a pair of arrangement tools 123 and the arrangement tools 123 allow the sample 101 to move within two orthogonal directions (X, Y) to the light source 105 and detectors 111, 117. A data processor 125 controls the system and is used to store data output from the detectors 111, 117.
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公开(公告)号：AU740150B2
公开(公告)日：2001-11-01
申请号：AU3751699
申请日：1999-04-19
Applicant: BIO RAD LABORATORIES
Inventor： CUNANAN CHRIS
Abstract: A scanning head assembly is provided, the scanning head suited for use with instruments that characterize the absorption, fluorescence, and/or luminescence properties of one or more samples contained within a sample plate or microplate. The scanning head assembly is coupled to a pair of scanning mechanisms, thereby allowing the head assembly to be raster scanned along both the x- and y-axis. Although the scanning preferably follows a serpentine pattern, other scan patterns can be utilized. Single or multiple measurements can be made per sample well, multiple measurements either being reported individually or averaged together. Although the scanning head assembly can utilize a variety of configurations, in the preferred embodiment the scanning head assembly has a C-shape with the light source and associated optics mounted in the lower arm of the assembly and the detector and associated optics mounted in the upper arm. Preferably the optics associated with the source include one or more optical filters that regulate the wavelength of light radiating the sample.
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公开(公告)号：CA2329236A1
公开(公告)日：1999-10-28
申请号：CA2329236
申请日：1999-04-19
Applicant: BIO RAD LABORATORIES
Inventor： CUNANAN CHRIS
Abstract: A scanning head assembly (101) is provided, the scanning head (101) suited f or use with instruments that characterize the absorption, fluorescence, and/or luminescence properties of one or more samples contained within a sample pla te or microplate (109). The scanning head assembly (101) is coupled to a pair o f scanning mechanisms (201, 203), thereby allowing the head assembly (101) to be raster scanned along both the x-axis (119) and y-axis (121). Although the scanning preferably follows a serpentine pattern (501), other scan patterns can be utilized. Single or multiple measurements can be made per sample well (123), multiple measurements either being reported individually or averaged together. Although the scanning head assembly (101) can utilize a variety of configurations, in the preferred embodiment the scanning head assembly (101) has a C-shape with the light source (103) and associated optics mounted in t he lower arm (111) of the assembly (101) and the detector (107) and associated optics mounted in the upper arm (113). Preferably the optics associated with the source (103) include one or more optical filters (413) that regulate the wavelength of light radiating from the sample.
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公开(公告)号：CA2217526A1
公开(公告)日：1998-04-11
申请号：CA2217526
申请日：1997-10-06
Applicant: BIO RAD LABORATORIES
Inventor： WITNEY FRANKLIN R , HEFFELFINGER DAVID M , CUNANAN CHRIS
Abstract: A method and apparatus of analyzing samples contained in a microplate is provided. The instrument is capable of measuring fluorescence, luminescence, and/or absorption within multiple locations within a sample well. The instrument is tunable over the excitation and/or detection wavelengths. Neutral density filters are used to extend the sensitivity range of the absorption measuring aspect of the instrument. Due to the wavelength tuning capabilities of the instrument, the spectral dependence of the measured fluorescence, luminescence, and absorption of the materials in question can be analyzed. The combination of a data processor and a look-up table improve the ease of operation of the instrument. Several different formats are available for the output data including creation of a bit map of the sample.
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Patent Agency Ranking
公开(公告)号：WO9954710A9
公开(公告)日：1999-12-16
申请号：PCT/US9908595
申请日：1999-04-19
Applicant: BIO RAD LABORATORIES
Inventor： CUNANAN CHRIS
CPC classification number: G01N21/6452 , G01N21/0332 , G01N21/253 , G01N35/028 , G01N2021/6419 , G01N2021/6471 , G01N2201/0618 , G01N2201/101
Abstract: A scanning head assembly (101) is provided, the scanning head (101) suited for use with instruments that characterize the absorption, fluorescence, and/or luminescence properties of one or more samples contained within a sample plate or microplate (109). The scanning head assembly (101) is coupled to a pair of scanning mechanisms (201, 203), thereby allowing the head assembly (101) to be raster scanned along both the x-axis (119) and y-axis (121). Although the scanning preferably follows a serpentine pattern (501), other scan patterns can be utilized. Single or multiple measurements can be made per sample well (123), multiple measurements either being reported individually or averaged together. Although the scanning head assembly (101) can utilize a variety of configurations, in the preferred embodiment the scanning head assembly (101) has a C-shape with the light source (103) and associated optics mounted in the lower arm (111) of the assembly (101) and the detector (107) and associated optics mounted in the upper arm (113). Preferably the optics associated with the source (103) include one or more optical filters (413) that regulate the wavelength of light radiating from the sample.
Abstract translation: 提供扫描头组件（101），该扫描头（101）适合与表征样品板或微板（109）内包含的一个或多个样品的吸收，荧光和/或发光特性的仪器一起使用。 扫描头组件（101）连接到一对扫描机构（201,203），从而允许头组件（101）沿x轴（119）和y轴（121）进行光栅扫描。 虽然扫描优选地遵循蛇形图案（501），但是可以利用其他扫描图案。 每个样品孔可以进行一次或多次测量（123），多次测量可以单独报告或一起平均。 尽管扫描头组件101可以采用多种结构，但在优选实施例中，扫描头组件101具有C形，光源103和相关光学元件安装在下臂111中， 组件（101）和检测器（107）以及安装在上臂（113）中的相关联的光学器件。 优选地，与源（103）相关联的光学器件包括调节从样品辐射的光的波长的一个或多个光学滤波器（413）。
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公开(公告)号：CA2329236C
公开(公告)日：2006-08-22
申请号：CA2329236
申请日：1999-04-19
Applicant: BIO RAD LABORATORIES
Inventor： CUNANAN CHRIS
Abstract: A scanning head assembly (101) is provided, the scanning head (101) suited f or use with instruments that characterize the absorption, fluorescence, and/or luminescence properties of one or more samples containe d within a sample plate or microplate (109). The scanning head assembly (101) is coupled to a pair of scanning mechanisms (201, 203), thereby allowing the head assembly (101) to be raster scanned along both the x-axis (119) and y-axis (121). Although the scanning preferab ly follows a serpentine pattern (501), other scan patterns can be utilized. Single or multiple measurements can be made per sample well (123), multiple measurements either being reported individually or averaged together. Although the scanning head assembly (101) can utilize a variety of configurations, in the preferred embodiment the scanning head assembly (101) has a C-shape with the light source (103) and associated optics mounted in the lower arm (111) of the assembly (101) and the detector (107) and associated optics mounted in the upper arm (113). Preferably the optics associated with the source (103) include one or more optical filters (413) that regulate the wavelength of light radiating from the sample.
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公开(公告)号：CA2217526C
公开(公告)日：2002-06-18
申请号：CA2217526
申请日：1997-10-06
Applicant: BIO RAD LABORATORIES
Inventor： CUNANAN CHRIS , WITNEY FRANKLIN R , HEFFELFINGER DAVID M
Abstract: A method and apparatus of analyzing samples contained in a microplate is provided. The instrument is capable of measuring fluorescence, luminescence, and/or absorption within multiple locations within a sample well. The instrument is tunable over the excitation and/or detection wavelengths. Neutral density filters are used to extend the sensitivity range of the absorption measuring aspect of the instrument. Due to the wavelength tuning capabilities of the instrument, the spectral dependence of the measured fluorescence, luminescence, and absorption of the materials in question can be analyzed. The combination of a data processor and a look-up table improve the ease of operation of the instrument. Several different formats are available for the output data including creation of a bit map of the sample.
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公开(公告)号：AU3751699A
公开(公告)日：1999-11-08
申请号：AU3751699
申请日：1999-04-19
Applicant: BIO RAD LABORATORIES
Inventor： CUNANAN CHRIS
Abstract: A scanning head assembly is provided, the scanning head suited for use with instruments that characterize the absorption, fluorescence, and/or luminescence properties of one or more samples contained within a sample plate or microplate. The scanning head assembly is coupled to a pair of scanning mechanisms, thereby allowing the head assembly to be raster scanned along both the x- and y-axis. Although the scanning preferably follows a serpentine pattern, other scan patterns can be utilized. Single or multiple measurements can be made per sample well, multiple measurements either being reported individually or averaged together. Although the scanning head assembly can utilize a variety of configurations, in the preferred embodiment the scanning head assembly has a C-shape with the light source and associated optics mounted in the lower arm of the assembly and the detector and associated optics mounted in the upper arm. Preferably the optics associated with the source include one or more optical filters that regulate the wavelength of light radiating the sample.
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公开(公告)号：EP1078242A4
公开(公告)日：2008-04-23
申请号：EP99919901
申请日：1999-04-19
Applicant: BIO RAD LABORATORIES
Inventor： CUNANAN CHRIS
CPC classification number: G01N21/6452 , G01N21/0332 , G01N21/253 , G01N35/028 , G01N2021/6419 , G01N2021/6471 , G01N2201/0618 , G01N2201/101
Abstract: A scanning head assembly (101) is provided, the scanning head (101) suited for use with instruments that characterize the absorption, fluorescence, and/or luminescence properties of one or more samples contained within a sample plate or microplate (109). The scanning head assembly (101) is coupled to a pair of scanning mechanisms (201, 203), thereby allowing the head assembly (101) to be raster scanned along both the x-axis (119) and y-axis (121). Although the scanning preferably follows a serpentine pattern (501), other scan patterns can be utilized. Single or multiple measurements can be made per sample well (123), multiple measurements either being reported individually or averaged together. Although the scanning head assembly (101) can utilize a variety of configurations, in the preferred embodiment the scanning head assembly (101) has a C-shape with the light source (103) and associated optics mounted in the lower arm (111) of the assembly (101) and the detector (107) and associated optics mounted in the upper arm (113). Preferably the optics associated with the source (103) include one or more optical filters (413) that regulate the wavelength of light radiating from the sample.
Abstract translation: 提供扫描头组件（101），该扫描头（101）适合与表征样品板或微板（109）内包含的一个或多个样品的吸收，荧光和/或发光特性的仪器一起使用。 扫描头组件（101）连接到一对扫描机构（201,203），从而允许头组件（101）沿x轴（119）和y轴（121）进行光栅扫描。 虽然扫描优选地遵循蛇形图案（501），但是可以利用其他扫描图案。 每个样品孔可以进行一次或多次测量（123），多次测量可以单独报告或一起平均。 尽管扫描头组件101可以采用多种结构，但在优选实施例中，扫描头组件101具有C形，光源103和相关光学元件安装在下臂111中， 组件（101）和检测器（107）以及安装在上臂（113）中的相关联的光学器件。 优选地，与源（103）相关联的光学器件包括调节从样品辐射的光的波长的一个或多个光学滤波器（413）。
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