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    ADJUSTABLE EXCITATION AND/OR ADJUSTABLE DETECTION MICROPLATE READER
    1.
    发明专利
    ADJUSTABLE EXCITATION AND/OR ADJUSTABLE DETECTION MICROPLATE READER 失效

    公开(公告)号：JPH10170429A

    公开(公告)日：1998-06-26

    申请号：JP27694897

    申请日：1997-10-09

    Applicant: BIO RAD LABORATORIES

    Inventor： HEFFELFINGER DAVID M ,  WITNEY FRANKLIN R ,  CUNANAN CHRIS

    IPC: G01N21/64 ,  G01N21/03 ,  G01N21/25 ,  G01N21/27 ,  G01N21/75

    Abstract: PROBLEM TO BE SOLVED: To measure fluorescence, luminescence and an absorption characteristic of a sample at a plurality of positions in a single sample well of a microplate, by setting an arrangement tool for moving a relative position of a sample-fixing tool and a detector. SOLUTION: A radiation from a light source 105 illuminates a sample 101 through an adjustment section 107 and an optical component 109. A fluorescence and/or a luminescence from the sample 101 forms an image on a detector 111 through an optical component 113 and an adjustment section 115. A second detector 117 is arranged below the sample 101 and used for the measurement of absorption. A fixing tool 103 is connected to a pair of arrangement tools 123 and the arrangement tools 123 allow the sample 101 to move within two orthogonal directions (X, Y) to the light source 105 and detectors 111, 117. A data processor 125 controls the system and is used to store data output from the detectors 111, 117.

    TUNABLE EXCITATION AND/OR TUNABLE DETECTION MICROPLATE READER
    2.
    发明专利
    TUNABLE EXCITATION AND/OR TUNABLE DETECTION MICROPLATE READER 未知

    公开(公告)号：CA2217526A1

    公开(公告)日：1998-04-11

    申请号：CA2217526

    申请日：1997-10-06

    Applicant: BIO RAD LABORATORIES

    Inventor： WITNEY FRANKLIN R ,  HEFFELFINGER DAVID M ,  CUNANAN CHRIS

    IPC: G01N21/64 ,  G01N21/03 ,  G01N21/25 ,  G01N21/27 ,  G01N21/75 ,  G01N21/59 ,  G01N21/63

    Abstract: A method and apparatus of analyzing samples contained in a microplate is provided. The instrument is capable of measuring fluorescence, luminescence, and/or absorption within multiple locations within a sample well. The instrument is tunable over the excitation and/or detection wavelengths. Neutral density filters are used to extend the sensitivity range of the absorption measuring aspect of the instrument. Due to the wavelength tuning capabilities of the instrument, the spectral dependence of the measured fluorescence, luminescence, and absorption of the materials in question can be analyzed. The combination of a data processor and a look-up table improve the ease of operation of the instrument. Several different formats are available for the output data including creation of a bit map of the sample.

    Tunable Excitation and/or Tunable Emission Fluorescence Imaging
    4.
    发明专利
    Tunable Excitation and/or Tunable Emission Fluorescence Imaging 未知

    公开(公告)号：CA2171588A1

    公开(公告)日：1996-09-17

    申请号：CA2171588

    申请日：1996-03-12

    Applicant: BIO RAD LABORATORIES

    Inventor： HEFFELFINGER DAVID M ,  WITNEY FRANKLIN R

    IPC: G01N21/91 ,  G01N21/25 ,  G01N21/64 ,  G01N21/77 ,  C12Q1/68

    Abstract: A method and apparatus to detect fluorescence from a sample is provided. The optical system allows the user to continuously tune the wavelengths and bandwidths of the excitation source and the emission detection system. A peaking function automatically peaks the detected fluorescent signal by fine tuning the excitation and emission detection systems. A look-up table allows the fluorescent signal for a specific wavelength to be corrected for the wavelength dependence of the optical train. In one embodiment of the system the sample is simultaneously irradiated in more than one wavelength band, each wavelength band being independently tunable.

    FIBER OPTIC STORAGE PHOSPHOR IMAGING PLATE SCANNER
    5.
    发明专利
    FIBER OPTIC STORAGE PHOSPHOR IMAGING PLATE SCANNER 未知

    公开(公告)号：CA2090717A1

    公开(公告)日：1993-09-04

    申请号：CA2090717

    申请日：1993-02-23

    Applicant: BIO RAD LABORATORIES

    Inventor： HEFFELFINGER DAVID M

    IPC: G01N21/64 ,  G01T1/29 ,  G02B3/00 ,  G02B6/04 ,  G02B6/28 ,  G02B6/32 ,  G02B26/10 ,  H04N1/028 ,  H04N1/04 ,  G01T1/105 ,  H04N1/21

    Abstract: 24 FIBER OPTIC STORAGE PHOSPHOR IMAGING PLATE SCANNER A novel fiber optic cable having a bifurcated bundle of optical fibers comprised of emitter fiber(s) and collecting fiber(s), a means for focusing light into the proximal end of the emitter fiber(s), a means for focusing light out of the distal end of the emitter fiber(s), and a means for collecting light in the distal end of the collecting fiber(s) is used to increase the sensitivity and specificity of storage phosphor imaging plate scanning. The novel fiber optic cable is used in a storage phosphor imaging plate scanner to transmit light from a light source to the phosphors on the storage phosphor imaging plate and to collect any phosphorescence induced by the light. Use of the bifurcated fiber bundle with the means for focusing light into the emitter fiber(s), focus light out of the emitter fiber(s), and collect light in the collecting fiber(s) provides a method to scan storage phosphor imaging plates with high sensitivity and specificity.

    MULTI PARAMETER SCANNER
    8.
    发明专利
    MULTI PARAMETER SCANNER 未知

    公开(公告)号：CA2299345A1

    公开(公告)日：1999-02-25

    申请号：CA2299345

    申请日：1998-08-11

    Applicant: BIO RAD LABORATORIES

    Inventor： HEFFELFINGER DAVID M ,  SALGADO RENATO ,  BATTERSON REBECCA ANN

    IPC: G01N21/64 ,  C12M1/00 ,  C12M1/34 ,  C12N15/09 ,  C12Q1/68 ,  G01N21/75 ,  G01N21/78 ,  G01N33/53 ,  G01N37/00 ,  G03B42/00

    Abstract: An apparatus capable of measuring quantities of biological or other types of samples that have been labeled using any of a variety of techniques including fluorescence, radioisotopes, enzyme activated light emitting chemicals and enzyme activated fluorescent materials is provided. The provided scanner includes a source module (113) that preferably contains an internal laser emitting two different wavelengths of approximately the same intensity. An optional external light source may be coupled to the source module, thus adding further flexibility through the addition of other wavelengths (e.g. UV, visible, mid-IR, and IR). The scanner also includes a detection module. Within the detection module (115) are two detectors, thus allowing the simultaneous detection of multiple wavelengths. A bifurcated optical cable (111) is used to transfer the excitation and/or readout light from the source module to the sample and subsequently transfer the emitted and/or scattered light from the sample to the detection module.

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