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    SIGNAL AMPLIFICATION FOR IMMUNOASSAYS BY USE OF AVIDIN-BIOTIN LINKAGES
    1.
    发明申请
    SIGNAL AMPLIFICATION FOR IMMUNOASSAYS BY USE OF AVIDIN-BIOTIN LINKAGES 审中-公开
    通过使用AVIDIN-BIOTIN链接免疫免疫的信号放大

    公开(公告)号：WO2012122121A3

    公开(公告)日：2014-02-27

    申请号：PCT/US2012027764

    申请日：2012-03-05

    Applicant: BIO RAD LABORATORIES ,  TAN WOEI ,  MONJI NOBUO ,  GUPTA VINITA ,  REYES CANDICE

    Inventor： TAN WOEI ,  MONJI NOBUO ,  GUPTA VINITA ,  REYES CANDICE

    IPC: G01N33/543 ,  G01N33/532

    CPC classification number: G01N33/54306 ,  G01N33/542

    Abstract: In sandwich-type immunoassays that capture a protein analyte between a capture antibody, typically bound to a solid phase, and a detection antibody that is coupled to a reporter group, the number of reporter groups associated with each molecule of analyte is increased by a variety of methods that utilize avidin-biotin-type binding in conjunction with such features as immunological binding to the reporter group on the detection antibody or multiple biotin-avidin-type binding sites.

    Abstract translation: 在通常与固相结合的捕获抗体和与报告基团连接的检测抗体之间捕获蛋白质分析物的夹心型免疫测定中，与每个分析物分子相关联的报告基团数量增加了多种 利用抗生物素蛋白 - 生物素型结合与检测抗体或多个生物素 - 抗生物素蛋白型结合位点等免疫学结合到报告基团的特征的方法。

    SIGNAL AMPLIFICATION FOR IMMUNOASSAYS BY USE OF AVIDIN-BIOTIN LINKAGES
    2.
    发明专利
    SIGNAL AMPLIFICATION FOR IMMUNOASSAYS BY USE OF AVIDIN-BIOTIN LINKAGES 未知

    公开(公告)号：CA2827536A1

    公开(公告)日：2012-09-13

    申请号：CA2827536

    申请日：2012-03-05

    Applicant: BIO RAD LABORATORIES

    Inventor： TAN WOEI ,  MONJI NOBUO ,  GUPTA VINITA ,  REYES CANDICE

    IPC: G01N33/53

    Abstract: In sandwich-type immunoassays that capture a protein analyte between a capture antibody, typically bound to a solid phase, and a detection antibody that is coupled to a reporter group, the number of reporter groups associated with each molecule of analyte is increased by a variety of methods that utilize avidin-biotin-type binding in conjunction with such features as immunological binding to the reporter group on the detection antibody or multiple biotin-avidin-type binding sites.

    MULTIPLEX BLOCKER BEADS FOR IMMUNOASSAYS
    3.
    发明申请
    MULTIPLEX BLOCKER BEADS FOR IMMUNOASSAYS 审中-公开
    用于免疫力的多重阻隔器珠

    公开(公告)号：WO2015017285A3

    公开(公告)日：2015-03-26

    申请号：PCT/US2014048283

    申请日：2014-07-25

    Applicant: BIO RAD LABORATORIES

    Inventor： TAN WOEI ,  JETHWANEY DEEPA ,  GUPTA VINITA ,  WANG QIAN-SHU ,  YEUNG DORIS

    IPC: G01N33/53

    CPC classification number: G01N33/54393

    Abstract: Provided are methods and compositions for immunoassay with improved specificity. The presently disclosed bead-based blocking agents reduce the interference associated with the samples and reagents of such assays. The presently disclosed blocking agents can be used to separate interfering molecules in a sample, resulting in increased sensitivity of an immunoassay. A method is provided for blocking an interfering molecule in an affinity assay mixture, wherein the mixture comprises a sample.

    Abstract translation: 提供了具有改善的特异性的用于免疫测定的方法和组合物。 目前公开的基于珠的封闭剂降低了与这种测定的样品和试剂相关的干扰。 目前公开的阻断剂可用于分离样品中的干扰分子，导致免疫测定的灵敏度增加。 提供了用于在亲和测定混合物中封闭干扰分子的方法，其中所述混合物包含样品。

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