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公开(公告)号：WO2013134251A3
公开(公告)日：2015-07-02
申请号：PCT/US2013029097
申请日：2013-03-05
Applicant: BIO RAD LABORATORIES
Inventor： LIAO JIALI , FROST RUSSELL
CPC classification number: B01J41/20 , B01D15/265 , B01D15/30 , B01D15/327 , B01D15/363 , B01D15/3847 , B01J20/22 , B01J20/267 , B01J20/28016 , B01J20/281 , B01J20/286 , B01J20/288 , B01J20/289 , B01J20/3208 , B01J20/3217 , B01J20/3219 , B01J20/3253 , B01J20/3265 , B01J20/3293 , B01J41/04 , B01J41/09 , B01J2220/52 , C07K1/14 , C07K1/16 , C07K1/165 , C07K16/00 , G01N30/482
Abstract: Anion exchange-hydrophobic mixed mode ligands and methods of their use are provided.
Abstract translation: 提供阴离子交换疏水混合模式配体及其使用方法。
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Patent Agency Ranking
公开(公告)号：WO2015138928A2
公开(公告)日：2015-09-17
申请号：PCT/US2015020484
申请日：2015-03-13
Applicant: BIO RAD LABORATORIES , RENSSELAER POLYTECH INST
Inventor： CRAMER STEVEN , WOO JAMES , CHEN HONG , LIAO JIALI , FROST RUSSELL
CPC classification number: B01J39/20 , B01J20/28004 , B01J20/28085 , B01J20/286 , B01J20/321 , B01J20/3253 , B01J20/3285 , B01J39/26 , B01J2220/82 , C07K1/165
Abstract: Mixed mode ligands, as well their use for purifying proteins, are provided.
Abstract translation: 提供了混合模式配体，以及其用于纯化蛋白质的用途。
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公开(公告)号：EP2986625A4
公开(公告)日：2016-12-14
申请号：EP15761242
申请日：2015-03-13
Applicant: BIO-RAD LABORATORIES INC , RENSSELAER POLYTECH INST
Inventor： CRAMER STEVEN , WOO JAMES , CHEN HONG , LIAO JIALI , FROST RUSSELL
CPC classification number: B01J39/20 , B01J20/28004 , B01J20/28085 , B01J20/286 , B01J20/321 , B01J20/3253 , B01J20/3285 , B01J39/26 , B01J2220/82 , C07K1/165
Abstract: Mixed mode ligands, as well their use for purifying proteins, are provided.
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公开(公告)号：EP3001833A4
公开(公告)日：2017-03-29
申请号：EP15790812
申请日：2015-06-24
Applicant: BIO-RAD LABORATORIES INC
Inventor： BERKELMAN TOM , LIAO JIALI
IPC: B82Y15/00 , C07K16/00 , G01N33/53 , G01N33/531 , G01N33/543
CPC classification number: G01N33/533 , A61K47/6929 , C07K1/34 , C07K16/00 , G01N33/54346
Abstract: Methods of purifying antibody-nanoparticle conjugates with size exclusion chromatography are provided.
Abstract translation: 设置有尺寸排阻色谱法纯化抗体 - 纳米颗粒缀合物的方法。
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公开(公告)号：EP2822687A4
公开(公告)日：2016-08-03
申请号：EP13758660
申请日：2013-03-05
Applicant: BIO RAD LABORATORIES
Inventor： LIAO JIALI , FROST RUSSELL
CPC classification number: B01J41/20 , B01D15/265 , B01D15/30 , B01D15/327 , B01D15/363 , B01D15/3847 , B01J20/22 , B01J20/267 , B01J20/28016 , B01J20/281 , B01J20/286 , B01J20/288 , B01J20/289 , B01J20/3208 , B01J20/3217 , B01J20/3219 , B01J20/3253 , B01J20/3265 , B01J20/3293 , B01J41/04 , B01J41/09 , B01J2220/52 , C07K1/14 , C07K1/16 , C07K1/165 , C07K16/00 , G01N30/482
Abstract: Solid supports and ligands are provided for purification of biomolecules by mixed-mode anion exchange-hydrophobic chromatography. Compositions can have the formula Support-(X)—N(R1, R2)—R3-L-Ar, or a salt thereof, wherein: Support is a chromatographic solid support; X is a spacer or absent; R1 and R2 are each selected from hydrogen and an alkyl comprising 1-6 carbons; R3 is an alkyl comprising 1-6 carbons or a cyclo alkyl comprising 1-6 carbons; L is NR4, O, or S; wherein R4 is hydrogen or an alkyl comprising 1-6 carbons; and Ar is an aryl. Methods are also provided for using solid supports and ligands to purify biomolecules such as monomeric antibodies.
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6.发明公开SOLID PHASE FOR MIXED-MODE CHROMATOGRAPHIC PURIFICATION OF PROTEINS 有权FESTPHASEFÜRDIE CHROMATOGRAPHISCHE REINIGUNG VON PROTEINEN IM MISCHMODUS
公开(公告)号：EP2768843A4
公开(公告)日：2015-07-01
申请号：EP12841318
申请日：2012-10-19
Applicant: BIO RAD LABORATORIES
Inventor： LIAO JIALI , OLECH LEE , CHEN HONG , HE XUEMEI , FROST RUSSELL
CPC classification number: B01J39/26 , C07K1/165 , C07K1/22 , C07K16/065
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