公开(公告)号：WO2015138928A2

公开(公告)日：2015-09-17

申请号：PCT/US2015020484

申请日：2015-03-13

Applicant: BIO RAD LABORATORIES ,  RENSSELAER POLYTECH INST

Inventor： CRAMER STEVEN ,  WOO JAMES ,  CHEN HONG ,  LIAO JIALI ,  FROST RUSSELL

IPC: B01J39/20 ,  C07K1/16

CPC classification number: B01J39/20 ,  B01J20/28004 ,  B01J20/28085 ,  B01J20/286 ,  B01J20/321 ,  B01J20/3253 ,  B01J20/3285 ,  B01J39/26 ,  B01J2220/82 ,  C07K1/165

Abstract: Mixed mode ligands, as well their use for purifying proteins, are provided.

Abstract translation: 提供了混合模式配体，以及其用于纯化蛋白质的用途。

公开(公告)号：CA2720615A1

公开(公告)日：2009-10-15

申请号：CA2720615

申请日：2009-04-07

Applicant: BIO RAD LABORATORIES

Inventor： GAGNON PETER S ,  CHEN HONG ,  FROST RUSS

IPC: A23J1/00

Abstract: Methods, kits and apparatuses for chromatography purification of antibodies are provided. In some embodiments, antibodies are purified by mixed mode chromatography that does not comprise hydroxyapatite (HT) or fluorapatite (FT). The mixed mode chromatography step is then followed by a HT/FT chromatography step.

公开(公告)号：CA2720615C

公开(公告)日：2016-06-07

申请号：CA2720615

申请日：2009-04-07

Applicant: BIO-RAD LABORATORIES INC

Inventor： GAGNON PETER S ,  CHEN HONG ,  FROST RUSS

IPC: C07K16/00 ,  A23J1/00 ,  B01D15/10 ,  C07K1/16 ,  C07K1/22

Abstract: Methods, kits and apparatuses for chromatography purification of antibodies are provided. In some embodiments, antibodies are purified by mixed mode chromatography that does not comprise hydroxyapatite (HT) or fluorapatite (FT). The mixed mode chromatography step is then followed by a HT/FT chromatography step.

公开(公告)号：EP2986625A4

公开(公告)日：2016-12-14

申请号：EP15761242

申请日：2015-03-13

Applicant: BIO-RAD LABORATORIES INC ,  RENSSELAER POLYTECH INST

Inventor： CRAMER STEVEN ,  WOO JAMES ,  CHEN HONG ,  LIAO JIALI ,  FROST RUSSELL

IPC: B01J20/286 ,  B01J20/28 ,  B01J20/32 ,  B01J39/20 ,  B01J39/26 ,  C07K1/16

CPC classification number: B01J39/20 ,  B01J20/28004 ,  B01J20/28085 ,  B01J20/286 ,  B01J20/321 ,  B01J20/3253 ,  B01J20/3285 ,  B01J39/26 ,  B01J2220/82 ,  C07K1/165

Abstract: Mixed mode ligands, as well their use for purifying proteins, are provided.

公开(公告)号：EP2768843A4

公开(公告)日：2015-07-01

申请号：EP12841318

申请日：2012-10-19

Applicant: BIO RAD LABORATORIES

Inventor： LIAO JIALI ,  OLECH LEE ,  CHEN HONG ,  HE XUEMEI ,  FROST RUSSELL

IPC: C07K1/16 ,  B01D15/10 ,  B01D15/20 ,  C07K1/22 ,  C07K1/36

CPC classification number: B01J39/26 ,  C07K1/165 ,  C07K1/22 ,  C07K16/065

公开(公告)号：EP2265129A4

公开(公告)日：2012-06-06

申请号：EP09729752

申请日：2009-04-07

Applicant: BIO RAD LABORATORIES

Inventor： GAGNON PETER S ,  CHEN HONG ,  FROST RUSS

IPC: A23J1/00 ,  B01D15/36 ,  B01D15/38

CPC classification number: C07K16/065 ,  A61K39/39591 ,  B01D15/36 ,  B01D15/3847 ,  C07K1/14 ,  C07K1/36 ,  C07K2317/24 ,  C07K2317/50