公开(公告)号：ES2326312T3

公开(公告)日：2009-10-07

申请号：ES02808314

申请日：2002-12-25

Applicant: BIO RAD LABORATORIES

Inventor： RAN BOAZ ,  NOTCOVICH ARIEL G ,  LIPSON ARIEL ,  NIMRI SHAY ,  LIPSON STEPHEN G ,  LIPSON DORON

IPC: G01N21/55 ,  G01J3/30 ,  G01N21/05

Abstract: Un sistema de iluminación para iluminar una superficie de sensor SPR (32) que tiene formada en la misma una capa conductora (33, 142, 152, 154), comprendiendo el sistema de iluminación: Una disposición (132) de fuentes de luz (26, 134); Un colimador (46) que dirige la luz desde cada fuente de luz (26, 134) en un haz colimado de luz de manera que la luz es incidente sobre la superficie de sensor (32); y Un controlador de fuentes de luz controlable para apagar y encender una fuente de luz (26, 134) en la disposición (132) independiente de las otras fuentes de luz en la disposición, caracterizado porque: La disposición (132) de las fuentes de luz (26, 134) es una disposición bidimensional (132) de filas (136) y columnas (138) de fuentes de luz (26, 134); y La luz de cada fuente de luz (26, 134) en una misma fila (136) ilumina la superficie de sensor (32) con sustancialmente un mismo ángulo de incidencia.

公开(公告)号：DE60232689D1

公开(公告)日：2009-07-30

申请号：DE60232689

申请日：2002-12-25

Applicant: BIO RAD LABORATORIES

Inventor： RAN BOAZ ,  NOTCOVICH ARIEL G ,  LIPSON ARIEL ,  NIMRI SHAY ,  LIPSON STEPHEN G ,  LIPSON DORON

IPC: G01N21/55 ,  G01J3/30 ,  G01N21/05

Abstract: An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen.

公开(公告)号：CA2781824A1

公开(公告)日：2011-06-03

申请号：CA2781824

申请日：2010-11-29

Applicant: BIO RAD LABORATORIES

Inventor： RAN BOAZ ,  SLUSZNY CHANAN ,  NIMRI SHAY

IPC: G01N21/64 ,  G01N15/14 ,  G01N21/76 ,  G01N21/78 ,  G01N33/543 ,  G01N33/58 ,  G06T7/00

Abstract: A method of determining a normalized quantity of an analyte adhering to beads ( 310 ) in a detection area ( 312 ) of a bead-based assaying system ( 300 ), the method comprising: a) causing a complex of the analyte to fluorescently or chemically emit a first light ( 2 ), or to release a dye; b) measuring an integrated intensity of the first light emitted from the beads in the detection area, or a concentration of the dye released from the beads in the detection area, or both; c) causing light ( 1 ) to interact with the beads in the detection area, the interaction not depending on whether or how much analyte is adhering to the beads; d) measuring a second light ( 1 ) resulting from the interaction with the beads which does not depend on the analyte; and e) determining the normalized quantity of analyte from the integrated intensity of the first light or concentration of the dye or both, and from the measured second light.

公开(公告)号：AT434175T

公开(公告)日：2009-07-15

申请号：AT02808314

申请日：2002-12-25

Applicant: BIO RAD LABORATORIES

Inventor： RAN BOAZ ,  NOTCOVICH ARIEL ,  LIPSON ARIEL ,  NIMRI SHAY ,  LIPSON DORON

IPC: G01N21/55 ,  G01J3/30 ,  G01N21/05

Abstract: An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen.

公开(公告)号：WO2013186672A3

公开(公告)日：2014-03-06

申请号：PCT/IB2013054660

申请日：2013-06-06

Applicant: BIO RAD LABORATORIES

Inventor： URI YOCHANAN ,  RAN BOAZ ,  NOTCOVICH ARIEL G ,  NIMRI SHAY

IPC: G01N21/03 ,  G01N21/55

CPC classification number: G01N21/553 ,  G01N21/253 ,  G01N21/658 ,  G01N33/54373 ,  G01N2021/0328 ,  G01N2201/0407 ,  G01N2201/0484 ,  G01N2201/062

Abstract: A tip for use in an optical detection system to analyze an analyte in a fluid sample drawn into the tip, using light reflected from a detection surface inside the tip that the analyte binds to, comprising a first detection surface and a second detection surface located in a same flow path with no controllable valve separating them, wherein the first and second detection surfaces have different surface chemistries.

Abstract translation: 一种用于光学检测系统的尖端，用于使用从分析物结合到所述尖端内部的检测表面反射的光来分析吸入所述尖端的流体样品中的分析物，所述检测表面包括第一检测表面和位于 相同的流动路径，没有可分离它们的可控阀，其中第一和第二检测表面具有不同的表面化学性质。

公开(公告)号：WO2011064778A3

公开(公告)日：2011-08-04

申请号：PCT/IL2010000993

申请日：2010-11-29

Applicant: BIO RAD LABORATORIES ,  RAN BOAZ ,  SLUSZNY CHANAN ,  NIMRI SHAY

Inventor： RAN BOAZ ,  SLUSZNY CHANAN ,  NIMRI SHAY

IPC: G01N21/64 ,  G01N15/14 ,  G01N21/76 ,  G01N21/78 ,  G01N33/543 ,  G01N33/58 ,  G06T7/00

CPC classification number: G01N21/76 ,  G01N15/0612 ,  G01N15/1463 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N21/78 ,  G01N35/0098 ,  G01N2015/1486 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2035/1046 ,  Y10T436/25

Abstract: A method of determining a normalized quantity of an analyte adhering to beads ( 310 ) in a detection area ( 312 ) of a bead-based assaying system ( 300 ), the method comprising: a) causing a complex of the analyte to fluorescently or chemically emit a first light ( 2 ), or to release a dye; b) measuring an integrated intensity of the first light emitted from the beads in the detection area, or a concentration of the dye released from the beads in the detection area, or both; c) causing light ( 1 ) to interact with the beads in the detection area, the interaction not depending on whether or how much analyte is adhering to the beads; d) measuring a second light ( 1 ) resulting from the interaction with the beads which does not depend on the analyte; and e) determining the normalized quantity of analyte from the integrated intensity of the first light or concentration of the dye or both, and from the measured second light.

Abstract translation: 一种确定附着在珠基测定系统（300）的检测区域（312）中的珠（310）的分析物的归一化量的方法，所述方法包括：a）使分析物的复合物进行荧光或化学 发出第一光（2），或释放染料; b）测量从检测区域中的珠子发射的第一光的集成强度或从检测区域中的珠粒释放的染料的浓度，或两者; c）导致光（1）与检测区域中的珠粒相互作用，相互作用不取决于是否或多少分析物粘附到珠粒上; d）测量与不依赖于分析物的珠的相互作用产生的第二光（1）; 以及e）根据所述第一光的积分强度或所述染料或两者的浓度以及所测量的第二光确定归一化的分析物量。

公开(公告)号：EP2987181A4

公开(公告)日：2016-11-30

申请号：EP14869552

申请日：2014-12-09

Applicant: BIO RAD LABORATORIES

Inventor： RAN BOAZ ,  SWIHART STEVE ,  THRUSH EVAN ,  BARAK ITAY

IPC: H01L23/552

CPC classification number: H04N5/361 ,  H01L2924/0002 ,  H04N5/365 ,  H01L2924/00

Abstract: One embodiment of the invention is directed to an imaging device comprising an image sensor comprising an array of pixels, and a mask coupled with the image sensor, the mask configured to darken at least one pixel in the array of pixels.

公开(公告)号：EP3167276A4

公开(公告)日：2018-03-14

申请号：EP15818252

申请日：2015-07-01

Applicant: BIO RAD LABORATORIES

Inventor： URI YOCHANAN ,  RAN BOAZ ,  BARAK ITAY ,  SWIHART STEVEN ,  THRUSH EVAN

IPC: G01N21/62 ,  G01N1/04 ,  G01N21/64 ,  G01N27/00 ,  G01N33/483

CPC classification number: H04N5/2252 ,  G01N21/64 ,  G01N27/00

Abstract: Provided herein are imaging cassettes for detecting a luminescent and/or radioactive signals. Such cassettes are useful in common biological assays, e.g., immunoassays, nucleotide detection assays, and other affinity assays.

公开(公告)号：EP2989443A4

公开(公告)日：2016-12-21

申请号：EP14869916

申请日：2014-12-09

Applicant: BIO-RAD LABORATORIES INC

Inventor： SWIHART STEVE ,  THRUSH EVAN ,  RAN BOAZ

IPC: G01N21/27 ,  G01N21/64 ,  G01N21/76 ,  H04N5/217 ,  H04N5/235 ,  H04N5/355 ,  H04N5/361

CPC classification number: H04N5/2355 ,  G01N21/272 ,  G01N21/6408 ,  G01N21/6456 ,  G01N21/76 ,  H04N5/2173 ,  H04N5/2353 ,  H04N5/35545 ,  H04N5/361 ,  H04N5/365

Abstract: Methods and digital imaging devices disclosed herein are adapted to capture images of a specimen in a chemical reaction using a series of short exposures of light emissions from the specimen over a period of time. The series of short exposures is captured using an array of pixels of an image sensor in the digital imaging device that are configured for performing continuous non-destructive read operations to read out a set of non-destructive read images of the specimen from the pixel array. In one embodiment, images are captured by delaying the read out until at or near the end of the chemical reaction to reduce read noise in the images. The signals read out from the image sensor can be continuously monitored and the capturing of images can be discontinued either automatically or based on a command from a user. The captured images can then be displayed in a graphical display.

Abstract translation: 本文公开的方法和数字成像装置适于在一段时间内使用来自样品的一系列短的曝光来捕获化学反应中的样本的图像。 使用数字成像装置中的图像传感器的像素阵列来捕获一系列短曝光，其被配置为执行连续的非破坏性读取操作，以从像素阵列读出样本的一组非破坏性读取图像 。 在一个实施例中，通过延迟读出直到化学反应结束或接近化学反应结束来捕获图像，以减少图像中的读取噪声。 可以连续地监视从图像传感器读出的信号，并且可以自动地或基于来自用户的命令中断图像的捕获。 然后可以在图形显示中显示所捕获的图像。