公开(公告)号：WO2009102694A1

公开(公告)日：2009-08-20

申请号：PCT/US2009/033646

申请日：2009-02-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BACHAND, Carol ,  MAKONEN, Belema ,  DEON, Daniel H. ,  GOOD, Andrew C. ,  GOODRICH, Jason ,  JAMES, Clint A. ,  LAVOIE, Rico ,  LOPEZ, Omar D. ,  MARTEL, Alain ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  YANG, Fukang ,  LANGLEY, David R. ,  WANG, Gan ,  HAMANN, Lawrence G.

Inventor： BACHAND, Carol ,  MAKONEN, Belema ,  DEON, Daniel H. ,  GOOD, Andrew C. ,  GOODRICH, Jason ,  JAMES, Clint A. ,  LAVOIE, Rico ,  LOPEZ, Omar D. ,  MARTEL, Alain ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  YANG, Fukang ,  LANGLEY, David R. ,  WANG, Gan ,  HAMANN, Lawrence G.

IPC: C07D403/14 ,  A61K31/517 ,  A61P31/00

CPC classification number: C07D403/14

Abstract: The present disclosure relates to compounds of formula (I), their compositions and their use in the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及式（I）的化合物，其组合物及其在治疗丙型肝炎病毒（HCV）感染中的用途。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2015005901A1

公开(公告)日：2015-01-15

申请号：PCT/US2013/049633

申请日：2013-07-09

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： HEWAWASAM, Piyasena ,  LOPEZ, Omar D. ,  TU, Yong ,  WANG, Alan Xiangdong ,  XU, Ningning ,  KADOW, John F. ,  MEANWELL, Nicholas A. ,  GUPTA, Samayamunthula Venkata Satya Arun Kumar ,  KUMAR, Indasi J. Gopi ,  PUNUGUPATI, Suresh Kumar ,  BELEMA, Makonen

IPC: A61K45/06 ,  A61K31/4164 ,  A61K31/4178 ,  A61P31/14

CPC classification number: A61K31/4178 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/519 ,  A61K31/5365 ,  A61K31/5377 ,  A61K31/695 ,  A61K31/7056 ,  A61K38/21 ,  A61K45/06 ,  A61K2300/00

Abstract: The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

Abstract translation: 本公开通常涉及抗病毒化合物，更具体地涉及可以抑制丙型肝炎病毒（HCV）编码的NS5A蛋白的功能的化合物的组合，包含这些组合的组合物，以及用于抑制NS5A的功能的方法 蛋白。

公开(公告)号：WO2010096302A1

公开(公告)日：2010-08-26

申请号：PCT/US2010/023582

申请日：2010-02-09

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  ROMINE, Jeffrey Lee ,  ST. LAURENT, Denis R. ,  BELEMA, Makonen ,  SNYDER, Lawrence B. ,  HAMANN, Lawrence G. ,  KADOW, John F. ,  KAPUR, Jayne ,  GOOD, Andrew C. ,  LOPEZ, Omar D. ,  LAVOIE, Rico ,  BENDER, John A.

Inventor： ROMINE, Jeffrey Lee ,  ST. LAURENT, Denis R. ,  BELEMA, Makonen ,  SNYDER, Lawrence B. ,  HAMANN, Lawrence G. ,  KADOW, John F. ,  KAPUR, Jayne ,  GOOD, Andrew C. ,  LOPEZ, Omar D. ,  LAVOIE, Rico ,  BENDER, John A.

IPC: C07D403/14 ,  A61K31/4184 ,  A61K31/4178 ,  A61P31/12 ,  C07D413/14

CPC classification number: C07D403/14 ,  A61K31/4184 ,  A61K31/422 ,  A61K31/454 ,  A61K31/4725 ,  A61K31/7056 ,  A61K38/2013 ,  A61K38/204 ,  A61K38/208 ,  A61K38/21 ,  A61K38/212 ,  A61K45/06 ,  C07D405/14 ,  C07D413/14

Abstract: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2012154777A1

公开(公告)日：2012-11-15

申请号：PCT/US2012/037012

申请日：2012-05-09

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  CHEN, Qi ,  LOPEZ, Omar D. ,  BENDER, John A. ,  WANG, Gan ,  NGUYEN, Van N. ,  KADOW, John F. ,  MEANWELL, Nicholas A. ,  BELEMA, Makonen

Inventor： CHEN, Qi ,  LOPEZ, Omar D. ,  BENDER, John A. ,  WANG, Gan ,  NGUYEN, Van N. ,  KADOW, John F. ,  MEANWELL, Nicholas A. ,  BELEMA, Makonen

IPC: C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  A61K31/4178 ,  A61P31/12

CPC classification number: C07D403/14 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/5377 ,  A61K45/06 ,  C07D405/14 ,  C07D413/14

Abstract: The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection of following Fomula (I). Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及用于治疗以下Fomula（I）的丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2011082077A1

公开(公告)日：2011-07-07

申请号：PCT/US2010/061855

申请日：2010-12-22

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  LOPEZ, Omar D. ,  ST. LAURENT, Denis R. ,  GOODRICH, Jason ,  ROMINE, Jeffrey Lee ,  SERRANO-WU, Michael ,  YANG, Fukang ,  KAKARLA, Ramesh ,  YANG, Xuejie ,  QIU, Yuping ,  SNYDER, Lawrence B.

Inventor： LOPEZ, Omar D. ,  ST. LAURENT, Denis R. ,  GOODRICH, Jason ,  ROMINE, Jeffrey Lee ,  SERRANO-WU, Michael ,  YANG, Fukang ,  KAKARLA, Ramesh ,  YANG, Xuejie ,  QIU, Yuping ,  SNYDER, Lawrence B.

IPC: C07D231/12 ,  C07D233/64 ,  C07D249/06 ,  C07D249/08 ,  C07D263/32 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  A61K31/341 ,  A61K31/381 ,  A61K31/41 ,  A61P31/14

CPC classification number: A61K31/415 ,  A61K31/4196 ,  A61K31/4245 ,  C07D231/12 ,  C07D233/58 ,  C07D233/64 ,  C07D249/06 ,  C07D249/08 ,  C07D249/12 ,  C07D263/32 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

Abstract: The present disclosure is generally directed to antiviral compounds, and more specifically directed to compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such compounds, and methods for inhibiting the function of the NS5A protein.

Abstract translation: 本公开一般涉及抗病毒化合物，更具体地涉及可以抑制由丙型肝炎病毒（HCV）编码的NS5A蛋白的功能的化合物，包含这些化合物的组合物，以及用于抑制NS5A蛋白功能的方法。

公开(公告)号：WO2010138368A1

公开(公告)日：2010-12-02

申请号：PCT/US2010/035527

申请日：2010-05-20

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  LOPEZ, Omar D. ,  CHEN, Qi ,  BELEMA, Makonen

Inventor： LOPEZ, Omar D. ,  CHEN, Qi ,  BELEMA, Makonen

IPC: C07D403/14

CPC classification number: C07D403/14

Abstract: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

公开(公告)号：WO2010117635A1

公开(公告)日：2010-10-14

申请号：PCT/US2010/028456

申请日：2010-03-24

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BENDER, John A. ,  HEWAWASAM, Piyasena ,  KADOW, John F. ,  LOPEZ, Omar D. ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  WANG, Gan ,  XU, Ningning ,  BELEMA, Makonen

Inventor： BENDER, John A. ,  HEWAWASAM, Piyasena ,  KADOW, John F. ,  LOPEZ, Omar D. ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  WANG, Gan ,  XU, Ningning ,  BELEMA, Makonen

IPC: C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  A61K31/4178 ,  A61P31/14

CPC classification number: C07D403/04 ,  C07D403/14 ,  C07D405/14

Abstract: This disclosure concerns novel compounds of Formula (I) as defined in the specification and compositions comprising such novel compounds. These compounds are useful antiviral agents, especially in inhibiting the function of the NS5A protein encoded by Hepatitis C virus (HCV). Thus, the disclosure also concerns a method of treating HCV related diseases or conditions by use of these novel compounds or a composition comprising such novel compounds.

Abstract translation: 本公开涉及如说明书中定义的式（I）新化合物和包含这些新化合物的组合物。 这些化合物是有用的抗病毒剂，特别是抑制由丙型肝炎病毒（HCV）编码的NS5A蛋白的功能。 因此，本公开还涉及通过使用这些新化合物或包含这些新化合物的组合物治疗HCV相关疾病或病症的方法。

公开(公告)号：WO2015026454A1

公开(公告)日：2015-02-26

申请号：PCT/US2014/046685

申请日：2014-07-15

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： WANG, Alan Xiangdong ,  LOPEZ, Omar D. ,  TU, Yong ,  BELEMA, Makonen

IPC: A61K31/4164 ,  A61K31/4178 ,  A61K31/4184 ,  C07D235/04 ,  A61P31/14

CPC classification number: C07D403/10 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/7056 ,  A61K38/21 ,  A61K45/06 ,  A61K2300/00

Abstract: The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

Abstract translation: 本公开通常涉及抗病毒化合物，更具体地涉及可以抑制丙型肝炎病毒（HCV）编码的NS5A蛋白的功能的化合物的组合，包含这些组合的组合物，以及用于抑制NS5A的功能的方法 蛋白。

公开(公告)号：WO2011059887A1

公开(公告)日：2011-05-19

申请号：PCT/US2010/055565

申请日：2010-11-05

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  LAVOIE, Rico ,  BENDER, John A. ,  YANG, Zhong ,  BELEMA, Makonen ,  LOPEZ, Omar D. ,  CHEN, Qi ,  WANG, Gan ,  HEWAWASAM, Piyasena

Inventor： LAVOIE, Rico ,  BENDER, John A. ,  YANG, Zhong ,  BELEMA, Makonen ,  LOPEZ, Omar D. ,  CHEN, Qi ,  WANG, Gan ,  HEWAWASAM, Piyasena

IPC: C07D401/14 ,  C07D403/14 ,  C07D471/04 ,  C07D487/04 ,  A61K31/506 ,  A61P31/14

CPC classification number: C07D309/06 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/5377 ,  A61K45/06 ,  C07D401/14 ,  C07D403/10 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

Abstract: The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2010117704A1

公开(公告)日：2010-10-14

申请号：PCT/US2010/028999

申请日：2010-03-29

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  LOPEZ, Omar D. ,  CHEN, Qi ,  BELEMA, Makonen ,  HAMANN, Lawrence G.

Inventor： LOPEZ, Omar D. ,  CHEN, Qi ,  BELEMA, Makonen ,  HAMANN, Lawrence G.

IPC: C07D403/14 ,  C07D413/14 ,  A61K31/422 ,  A61K31/4184 ,  A61P31/00

CPC classification number: C07D403/14 ,  C07D413/14

Abstract: This disclosure concerns novel compounds of Formula (I) as defined in the specification and compositions comprising such novel compounds. These compounds are useful antiviral agents, especially in inhibiting the function of the NS5A protein encoded by Hepatitis C virus (HCV). Thus, the disclosure also concerns a method of treating HCV related diseases or conditions by use of these novel compounds or a composition comprising such novel compounds.

Abstract translation: 本公开涉及说明书中定义的式（I）的新化合物和包含这种新化合物的组合物。 这些化合物是有用的抗病毒剂，特别是在抑制由丙型肝炎病毒（HCV）编码的NS5A蛋白的功能中。 因此，本公开还涉及通过使用这些新化合物或包含这种新化合物的组合物来治疗HCV相关疾病或病症的方法。