公开(公告)号：WO2008112863A1

公开(公告)日：2008-09-18

申请号：PCT/US2008/056807

申请日：2008-03-13

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  HEWAWASAM, Piyasena ,  TU, Yong

Inventor： HEWAWASAM, Piyasena ,  TU, Yong

IPC: C07D487/04 ,  A61K31/55 ,  A61P31/12

CPC classification number: C07D487/04

Abstract: The invention encompasses compounds of formula (I) as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.

Abstract translation: 本发明包括式（I）的化合物以及使用该化合物的组合物和方法。 这些化合物对丙型肝炎病毒（HCV）具有活性，可用于治疗感染HCV的患者。

公开(公告)号：WO2008112848A1

公开(公告)日：2008-09-18

申请号：PCT/US2008/056778

申请日：2008-03-13

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  GENTLES, Robert G. ,  ZHENG, Xiaofan ,  DING, Min ,  TU, Yong ,  HAN, Ying ,  HEWAWASAM, Piyasena ,  KADOW, John F. ,  BENDER, John A. ,  YEUNG, Kap-Sun ,  GRANT-YOUNG, Katharine A. ,  HUDYMA, Thomas W.

Inventor： GENTLES, Robert G. ,  ZHENG, Xiaofan ,  DING, Min ,  TU, Yong ,  HAN, Ying ,  HEWAWASAM, Piyasena ,  KADOW, John F. ,  BENDER, John A. ,  YEUNG, Kap-Sun ,  GRANT-YOUNG, Katharine A. ,  HUDYMA, Thomas W.

IPC: C07D487/04 ,  A61P31/12 ,  A61K31/55

CPC classification number: C07D487/04

Abstract: The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.

公开(公告)号：WO2017023631A1

公开(公告)日：2017-02-09

申请号：PCT/US2016/044158

申请日：2016-07-27

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： FRENNESSON, David B. ,  HEWAWASAM, Piyasena ,  LOPEZ, Omar D. ,  NGUYEN, Van N. ,  SAULNIER, Mark G. ,  TU, Yong ,  WANG, Alan Xiangdong ,  WANG, Gan ,  XU, Ningning ,  NIMJE, Roshan Yadavrao ,  RAHAMAN, Hasibur ,  GUPTA, Samayamunthula Venkata Satya Arun Kumar ,  MEANWELL, Nicholas A. ,  BELEMA, Makonen

IPC: A61K45/06 ,  A61K38/21 ,  A61K31/417 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/7056 ,  A61P31/14

CPC classification number: A61K31/4184 ,  A61K31/417 ,  A61K31/4178 ,  A61K31/7056 ,  A61K38/21 ,  A61K45/06 ,  A61K2300/00

Abstract: The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

Abstract translation: 本公开通常涉及抗病毒化合物，更具体地涉及可以抑制丙型肝炎病毒（HCV）编码的NS5A蛋白的功能的化合物的组合，包含这些组合的组合物，以及用于抑制NS5A的功能的方法 蛋白。

公开(公告)号：WO2008112851A1

公开(公告)日：2008-09-18

申请号：PCT/US2008/056789

申请日：2008-03-13

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  YEUNG, Kap-sun ,  BENDER, John A. ,  GENTLES, Robert G. ,  YANG, Zhong ,  DING, Min ,  TU, Yong ,  HEWAWASAM, Piyasena ,  HAN, Ying ,  KADOW, John F.

Inventor： YEUNG, Kap-sun ,  BENDER, John A. ,  GENTLES, Robert G. ,  YANG, Zhong ,  DING, Min ,  TU, Yong ,  HEWAWASAM, Piyasena ,  HAN, Ying ,  KADOW, John F.

IPC: C07D487/04 ,  A61K31/55 ,  A61P31/12 ,  C07D519/00

CPC classification number: C07D487/04 ,  C07D519/00

Abstract: The invention encompasses compounds of Formula I, pharmaceutically acceptable salts thereof, compositions, and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.

Abstract translation: 本发明包括式I的化合物，其药学上可接受的盐，组合物和使用该化合物的方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。

公开(公告)号：WO2013106520A1

公开(公告)日：2013-07-18

申请号：PCT/US2013/020954

申请日：2013-01-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： HEWAWASAM, Piyasena ,  KADOW, John, F. ,  LOPEZ, Omar, D. ,  MEANWELL, Nicholas, A. ,  TU, Yong ,  WANG, Alan Xiangdong ,  XU, Ningning ,  BELEMA, Makonen ,  FRIDELL, Robert, A. ,  GAO, Min ,  LEMM, Julie, A. ,  O'BOYLE II, Donald, R. ,  SUN, Jin-Hua ,  WANG, Chunfu ,  WANG, Ying-Kai ,  GUPTA, Samayamunthula, Venkata, Satya, Arun, Kumar ,  SRINIVASU, Pothukanuri ,  KUMAR, Indasi, Gopi ,  KUMAR, Ponugupati Suresh

IPC: A61K31/4178 ,  A61P31/14 ,  A61K45/06

CPC classification number: A61K31/4178 ,  A61K31/407 ,  A61K31/4184 ,  A61K31/422 ,  A61K31/423 ,  A61K31/428 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/497 ,  A61K31/498 ,  A61K31/501 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/7056 ,  A61K38/05 ,  A61K38/21 ,  A61K38/212 ,  A61K38/217 ,  A61K45/06 ,  C07D403/14 ,  C07D491/113 ,  A61K2300/00

Abstract: The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

Abstract translation: 本公开通常涉及抗病毒化合物，更具体地涉及可以抑制丙型肝炎病毒（HCV）编码的NS5A蛋白的功能的化合物的组合，包含这些组合的组合物，以及用于抑制NS5A的功能的方法 蛋白。

公开(公告)号：WO2005054430A3

公开(公告)日：2005-06-16

申请号：PCT/US2004/038967

申请日：2004-11-19

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  TU, Yong ,  SCOLA, Paul, Michael ,  GOOD, Andrew, Charles ,  CAMPBELL, Jeffrey, Allen

Inventor： TU, Yong ,  SCOLA, Paul, Michael ,  GOOD, Andrew, Charles ,  CAMPBELL, Jeffrey, Allen

IPC: A61K31/40

Abstract: Hepatitis C virus inhibitors are disclosed having the general formula: (I) wherein R 1 , R 2 , R 3 , R', B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

公开(公告)号：WO2015026454A1

公开(公告)日：2015-02-26

申请号：PCT/US2014/046685

申请日：2014-07-15

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： WANG, Alan Xiangdong ,  LOPEZ, Omar D. ,  TU, Yong ,  BELEMA, Makonen

IPC: A61K31/4164 ,  A61K31/4178 ,  A61K31/4184 ,  C07D235/04 ,  A61P31/14

CPC classification number: C07D403/10 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/7056 ,  A61K38/21 ,  A61K45/06 ,  A61K2300/00

Abstract: The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

Abstract translation: 本公开通常涉及抗病毒化合物，更具体地涉及可以抑制丙型肝炎病毒（HCV）编码的NS5A蛋白的功能的化合物的组合，包含这些组合的组合物，以及用于抑制NS5A的功能的方法 蛋白。

公开(公告)号：WO2008112841A1

公开(公告)日：2008-09-18

申请号：PCT/US2008/056766

申请日：2008-03-13

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BENDER, John A. ,  GENTLES, Robert G. ,  HAN, Ying ,  TU, Yong ,  YANG, Zhong ,  YEUNG, Kap-Sun ,  GRANT-YOUNG, Katharine A.

Inventor： BENDER, John A. ,  GENTLES, Robert G. ,  HAN, Ying ,  TU, Yong ,  YANG, Zhong ,  YEUNG, Kap-Sun ,  GRANT-YOUNG, Katharine A.

IPC: C07D487/04 ,  A61P31/12 ,  A61K31/55

CPC classification number: C07D487/04

Abstract: The invention encompasses compounds of formula (I) as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.

Abstract translation: 本发明包括式（I）的化合物以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。

公开(公告)号：WO2004043339A2

公开(公告)日：2004-05-27

申请号：PCT/US2003/015780

申请日：2003-05-20

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  CAMPBELL, Jeffrey, Allen ,  D'ANDREA, Stanley, V. ,  GOOD, Andrew ,  LI, Jianqing ,  MCPHEE, Fiona ,  RIPKA, Amy ,  SCOLA, Paul, Michael ,  TU, Yong

Inventor： CAMPBELL, Jeffrey, Allen ,  D'ANDREA, Stanley, V. ,  GOOD, Andrew ,  LI, Jianqing ,  MCPHEE, Fiona ,  RIPKA, Amy ,  SCOLA, Paul, Michael ,  TU, Yong

IPC: A61K

CPC classification number: C07K5/0827 ,  A61K38/21 ,  C07K5/0802 ,  C07K5/0808 ,  C07K5/0812 ,  A61K2300/00

Abstract: The present invention relates to tripeptide compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. In particular, the present invention provides novel tripeptide analogs, pharmaceutical compositions containing such analogs and methods for using these analogs in the treatment of HCV infection.

Abstract translation: 本发明涉及用于治疗丙型肝炎病毒（HCV）感染的三肽化合物，组合物和方法。 特别地，本发明提供新颖的三肽类似物，含有这些类似物的药物组合物和使用这些类似物治疗HCV感染的方法。

公开(公告)号：WO2015005901A1

公开(公告)日：2015-01-15

申请号：PCT/US2013/049633

申请日：2013-07-09

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： HEWAWASAM, Piyasena ,  LOPEZ, Omar D. ,  TU, Yong ,  WANG, Alan Xiangdong ,  XU, Ningning ,  KADOW, John F. ,  MEANWELL, Nicholas A. ,  GUPTA, Samayamunthula Venkata Satya Arun Kumar ,  KUMAR, Indasi J. Gopi ,  PUNUGUPATI, Suresh Kumar ,  BELEMA, Makonen

IPC: A61K45/06 ,  A61K31/4164 ,  A61K31/4178 ,  A61P31/14

CPC classification number: A61K31/4178 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/519 ,  A61K31/5365 ,  A61K31/5377 ,  A61K31/695 ,  A61K31/7056 ,  A61K38/21 ,  A61K45/06 ,  A61K2300/00

Abstract: The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

Abstract translation: 本公开通常涉及抗病毒化合物，更具体地涉及可以抑制丙型肝炎病毒（HCV）编码的NS5A蛋白的功能的化合物的组合，包含这些组合的组合物，以及用于抑制NS5A的功能的方法 蛋白。