公开(公告)号：JP2008259505A

公开(公告)日：2008-10-30

申请号：JP2008095922

申请日：2008-04-02

Applicant: Basf Se ,  ビーエーエスエフ ソシエタス・ヨーロピアBasf Se

Inventor： ZELDER OSKAR ,  KLOPPROGGE CORINNA ,  SCHROEDER HARTWIG ,  HAEFNER STEFAN ,  KROEGER BURKHARD ,  KIEFER PATRICK ,  HEINZLE ELMAR ,  WITTMANN CHRISTOPH

IPC: C12N1/21 ,  C12N9/16 ,  C12N15/09 ,  C12P13/08

CPC classification number: C12P13/08 ,  C12N9/16

Abstract: PROBLEM TO BE SOLVED: To provide a method for accumulating and producing fine chemical materials (e.g., lysine) in a medium of an microorganism or the microorganism by increasing metabolic inflow through pentose phosphate route in the microorganism. SOLUTION: A method for increasing generation of fine chemical materials such as lysine from a microorganism, e.g., a corynebacterium by deregulating a ferment-encoding gene, i.e., fructose-1,6-bisphosphatase, is provided. Further, a new method for producing lysine by regulating carbon inflow directing to oxaloacetic acid (OAA), is also provided. In one a preferable embodiment, a method for producing lysine by using fructose or sucrose as the carbon source is provided. COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 待解决的问题：提供一种通过在微生物中通过戊糖磷酸途径增加代谢流入而在微生物或微生物的培养基中积累和生产精细化学物质（例如赖氨酸）的方法。 解决方案：提供了通过使发酵编码基因（即果糖-1,6-二磷酸酶）失调来增加来自微生物例如棒状杆菌的精细化学物质如赖氨酸的产生的方法。 此外，还提供了通过调节引入草酰乙酸（OAA）的碳流入来生产赖氨酸的新方法。 在一个优选实施方案中，提供了通过使用果糖或蔗糖作为碳源来生产赖氨酸的方法。 版权所有（C）2009，JPO＆INPIT

公开(公告)号：BRPI0614891A2

公开(公告)日：2012-12-25

申请号：BRPI0614891

申请日：2006-08-18

Applicant: BASF SE

Inventor： ZELDER OSKAR ,  SCHROEDER HARTWIG ,  KROEMER JENS ,  PERO JANICE ,  YOCUM ROGERS ,  PATTERSON THOMAS ,  WILLIAMS MARK ,  HEROLD ANDREA ,  KLOPPROGGE CORINNA ,  HAEFNER STEFAN ,  HEINZLE ELMAR ,  WITTMANN CHRISTOPH ,  HERMANN THERON

IPC: C12N15/52 ,  C12P13/12 ,  C12R1/13 ,  C12R1/19

Abstract: The present invention relates to methods for the production of microorganisms with increased efficiency for methionine synthesis, microorganisms with increased efficiency for methionine synthesis, and methods for determining the optimal metabolic flux for organisms with respect to methionine synthesis.

公开(公告)号：BRPI0618080A2

公开(公告)日：2012-02-22

申请号：BRPI0618080

申请日：2006-10-23

Applicant: BASF SE

Inventor： ZELDER OSKAR ,  HEROLD ANDREA ,  KLOPPROGGE CORINNA ,  SCHROEDER HARTWIG ,  HAEFNER STEFAN ,  HEINZLE ELMAR ,  WITTMANN CHRISTOPH ,  KROEMER JENS ,  PERO JANICE G ,  YOCUM R ROGERS ,  PATTERSON THOMAS A ,  WILLIAMS MARK ,  HERMANN THERON

IPC: A23K1/00 ,  C12N15/52 ,  C12P13/12

Abstract: The present invention relates to microorganisms and processes for the efficient preparation of L-amino acids such as L-methionine. In particular, the present invention relates to microorganisms and processes in which the formation and/or accumulation of homolanthionine in the methionine pathway is reduced and/or prevented.