Abstract:
PROBLEM TO BE SOLVED: To provide a method for accumulating and producing fine chemical materials (e.g., lysine) in a medium of an microorganism or the microorganism by increasing metabolic inflow through pentose phosphate route in the microorganism. SOLUTION: A method for increasing generation of fine chemical materials such as lysine from a microorganism, e.g., a corynebacterium by deregulating a ferment-encoding gene, i.e., fructose-1,6-bisphosphatase, is provided. Further, a new method for producing lysine by regulating carbon inflow directing to oxaloacetic acid (OAA), is also provided. In one a preferable embodiment, a method for producing lysine by using fructose or sucrose as the carbon source is provided. COPYRIGHT: (C)2009,JPO&INPIT
Abstract:
The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the wcaJ-gene. The present invention also relates to a method for producing an organic compound and to the use of a modified microorganism.
Abstract:
Recombinant microorganisms comprising DNA molecules in a deregulated form which improve the production of cadaverine or N-acetylcadaverine, as well as recombinant DNA molecules and polypeptides used to produce the microorganisms are provided. Said microorganisms comprise an intracellular lysine decarboxylase activity and a deregulated cadaverine export activity, or comprise a decreased cadaverine export activity and an enhanced N-acetylcadaverine forming activity. Processes for the production of cadaverine N-acetylcadaverine using the recombinant microorganisms are also provided.
Abstract:
Recombinant microorganisms with deregulated succinyl-CoA synthetase activity, as well as the uses for producing lysine, β-lysine, cadaverine or N-acetylcadaverine thereby are provided. Recombinant polypeptides comprising an amino acid sequence being at least 80% identical to SEQ ID NO: 51 or 53 are also provided. The method of producing fine chemicals using said recombinant microorganisms, in particular the method of producing lysine, or derivatives thereof, such as β-lysine, cadaverine or N-acetylcadaverine is further provided.
Abstract translation:重组微生物具有失调的琥珀酰辅酶A合成酶活性,以及作为制造赖氨酸,β-赖氨酸,尸胺或N-乙酰尸胺的用途,由此提供。 重组多肽,其包含的氨基酸序列有至少80%相同于SEQ ID NO:提供51或53因此。 还提供了使用所述重组微生物生产精细化学品,尤其是生产赖氨酸的方法,或它们的衍生物,:例如β-赖氨酸,尸胺或N-乙酰尸胺的方法。
Abstract:
Un microorganismo modificado que tiene, en comparación con su tipo silvestre, una actividad reducida de la enzima que está codificada por el gen pykA, en el que la actividad de la enzima codificada por el gen pykA se reduce por modificación genética, en el que la reducción de la actividad la enzima codificada por el gen pykA está en el intervalo de 15 a 99 %, en el que el tipo silvestre del cual se deriva el microorganismo modificado pertenece a la familia de Pasteurellaceae y en el que el tipo silvestre se refiere al microorganismo de origen natural que no ha sido modificado genéticamente.
Abstract:
The present invention relates to microorganisms and processes for the efficient preparation of L-amino acids such as L-methionine. In particular, the present invention relates to microorganisms and processes in which the formation and/or accumulation of homolanthionine in the methionine pathway is reduced and/or prevented.
Abstract:
Un microorganismo modificado de la familia Pasteurellaceae en el cual el gen wcaJ se ha delecionado o en el cual se ha introducido al menos una mutación en el gen wcaJ que conduce a la expresión de una enzima truncada codificada por el gen wcaJ en la cual al menos 100 aminoácidos de la enzima de tipo silvestre codificada por el gen wcaJ se delecionan del extremo C terminal, en el que el gen wcaJ comprende un ácido nucleico seleccionado del grupo que consiste en: a) ácidos nucleicos que tienen la secuencia nucleotídica de SEQ ID NO: 3; b) ácidos nucleicos que codifican la secuencia de aminoácidos de SEQ ID NO: 4; c) ácidos nucleicos que son al menos 70 % idénticos al ácido nucleico de a) o b), siendo la identidad la identidad en la longitud total de los ácidos nucleicos de a) o b); d) ácidos nucleicos que codifican una secuencia de aminoácidos que es al menos 70 % idéntica a la secuencia de aminoácidos codificada por el ácido nucleico de a) o b), siendo la identidad la identidad en la longitud total de la secuencia de aminoácidos codificada por los ácidos nucleicos de a) o b), e) ácidos nucleicos capaces de hibridar en condiciones rigurosas con una secuencia complementaria de cualquiera de los ácidos nucleicos de acuerdo con a) o b); y f) ácidos nucleicos que codifican la misma proteína que cualquiera de los ácidos nucleicos de a) o b), pero que difieren de los ácidos nucleicos de a) o b) anteriores debido a la degeneración del código genético.
Abstract:
The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the wcaJ-gene. The present invention also relates to a method for producing an organic compound and to the use of a modified microorganism.
Abstract:
The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the pykA-gene. The present invention also relates to a method for producing an organic compound and to the use of modified microorganisms.