公开(公告)号：WO2006017217A3

公开(公告)日：2006-04-06

申请号：PCT/US2005024518

申请日：2005-07-11

Applicant: CALIFORNIA INST OF TECHN ,  HOPE CITY ,  TAI YU-CHONG ,  XIE JUN ,  SHIH JASON ,  LEE TERRY ,  MIAO YUNAN

Inventor： TAI YU-CHONG ,  XIE JUN ,  SHIH JASON ,  LEE TERRY ,  MIAO YUNAN

IPC: G01N30/34 ,  G01N30/72 ,  H01J49/04

CPC classification number: H01J49/04 ,  B01L3/5027 ,  G01N30/6095 ,  G01N30/7233 ,  G01N2030/326

Abstract: A microfluidic system with on-chip pumping which can be used for liquid chromatography and also electrospray ionization mass spectrometry and which provides improved efficiency, better integration with sensors, improved portability, reduced power consumption, and reduced cost. The system can include (A) a main chip comprising: a substrate having a front face and a back face; a chromatography column on the front face of said substrate, wherein said column has an inlet and an outlet; an electrospray ionization (ESI) nozzle on the front face of said substrate, wherein said nozzle has an inlet and an outlet, and wherein the inlet of the nozzle is microfluidically coupled to the outlet of the column; one or more pump systems on the front face of said substrate comprising a pump chamber, one or more electrodes, and an outlet microfluidically coupled to the inlet of said column; and (B) a reservoir chip comprising a front surface and a back surface, wherein the reservoir chip has one or more cavities in the back surface which when disposed next to the front surface of the main chip extends the volume of the pump chamber of one of the pump system. Microfabrication can be used to prepare the chips, which can be assembled with a cover and inserted into a testing jig for electronic control and mass spectral analysis. Peptide separations are demonstrated which compete with present commercial systems.

Abstract translation: 具有片上泵送功能的微流控系统可用于液相色谱和电喷雾电离质谱分析，并提供更高的效率，更好地与传感器集成，改进便携性，降低功耗和降低成本。 该系统可以包括（A）主芯片，其包括：具有正面和背面的衬底; 在所述基底的正面上的色谱柱，其中所述柱具有入口和出口; 在所述基底的前表面上的电喷雾电离（ESI）喷嘴，其中所述喷嘴具有入口和出口，并且其中所述喷嘴的入口微流体耦合到所述柱的出口; 在所述衬底的正面上的一个或多个泵系统，其包括泵室，一个或多个电极以及微流体地耦合到所述柱的入口的出口; （B）包括前表面和后表面的储存器芯片，其中所述储存器芯片在后表面中具有一个或多个空腔，当所述空腔布置在主芯片的前表面附近时，泵腔的体积 的泵系统。 微细加工可以用来制备芯片，芯片可以用盖子组装并插入到用于电子控制和质谱分析的测试夹具中。 证明肽分离与目前的商业系统竞争。

公开(公告)号：EP0958593A4

公开(公告)日：2006-08-30

申请号：EP98906009

申请日：1998-01-27

Applicant: CALIFORNIA INST OF TECHN

Inventor： TAI YU-CHONG ,  DESAI AMISH ,  LEE TERRY ,  DAVIS MIKE

IPC: H01J49/04 ,  H01J49/10

CPC classification number: H01J49/167 ,  H01J49/0018 ,  H01J49/04

Abstract: A MEMS electrospray nozzle (320) for mass spectroscopy is disclosed. The nozzle has: a channel field (380) having an inner diameter between 0.3-3 νm; a nozzle tip (390); and a filter structure (370) positioned on the channel field. A method of fabricating the nozzle is also disclosed.

Abstract translation: 公开了用于质谱的MEMS电喷嘴（320）。 该喷嘴具有：内径在0.3-3νm之间的通道区域（380） 一个喷嘴尖端（390）; 和位于通道场上的滤波器结构（370）。 还公开了制造喷嘴的方法。

公开(公告)号：AU6135298A

公开(公告)日：1998-08-26

申请号：AU6135298

申请日：1998-01-27

Applicant: CALIFORNIA INST OF TECHN

Inventor： TAI YU-CHONG ,  DESAI AMISH ,  LEE TERRY ,  DAVIS MIKE

IPC: H01J49/04 ,  H01J49/10