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    MULTI-SITE REACTOR SYSTEM WITH DYNAMIC, INDEPENDENT CONTROL OF INDIVIDUAL REACTION SITES
    4.
    发明申请
    MULTI-SITE REACTOR SYSTEM WITH DYNAMIC, INDEPENDENT CONTROL OF INDIVIDUAL REACTION SITES 审中-公开
    具有独立反应场所独立控制的多场反应器系统

    公开(公告)号：WO9948608A3

    公开(公告)日：1999-12-09

    申请号：PCT/US9906628

    申请日：1999-03-23

    Applicant: CEPHEID

    Inventor： YOUNG STEVEN J ,  KOVACS GREGORY T A ,  NORTHRUP M ALLEN ,  PETERSEN KURT E ,  MCMILLAN WILLIAM A ,  OTHMER KONSTANTIN ,  CHRISTEL LEE A

    IPC: C12Q1/68 ,  B01J19/00 ,  B01L7/00 ,  G05B13/02 ,  G05D23/19

    CPC classification number: B01L7/52 ,  G05B13/021 ,  G05D23/1913

    Abstract: A multi-site reactor system (60) provides dynamic, independent, computer-implemented control of each reaction site, permitting different thermal profiles to be performed on samples at different reaction sites simultaneously. The system includes reaction vessels (2) for holding reaction mixtures and heat-exchanging modules (37) for receiving the vessels. The system also includes a controller (64) for independently controlling each heat-exchanging module (37) to heat and/or cool the reaction mixture contained therein. The controller (64) includes an adaptive control program for dynamically adjusting the duration or intensity of power pulses provided to each heating element and for dynamically adjusting the duration of fan operation to attain target temperatures quickly and accurately without overshooting or undershooting the target.

    Abstract translation: 多位点反应器系统（60）为每个反应位点提供动态，独立的计算机实现的控制，允许在不同反应位点的样品上同时进行不同的热分布。 该系统包括用于保持反应混合物的反应容器（2）和用于接收容器的热交换模块（37）。 该系统还包括用于独立地控制每个热交换模块（37）以加热和/或冷却其中包含的反应混合物的控制器（64）。 控制器（64）包括一个自适应控制程序，用于动态地调整提供给每个加热元件的功率脉冲的持续时间或强度，并且用于动态地调整风扇操作的持续时间以快速且准确地达到目标温度，而不会超标或低于目标。

    Multi-channel optical detection system
    5.
    发明专利
    Multi-channel optical detection system 未知

    公开(公告)号：AU746069B2

    公开(公告)日：2002-04-11

    申请号：AU4194099

    申请日：1999-05-19

    Applicant: CEPHEID

    Inventor： CHRISTEL LEE A ,  NORTHRUP M ALLEN ,  PETERSEN KURT E ,  MCMILLAN WILLIAM A ,  KOVACS GREGORY T A ,  YOUNG STEVEN J ,  CHANG RONALD ,  DORITY DOUGLAS B ,  HEBERT RAYMOND ,  KINTZ GREGORY J

    IPC: G01N21/64 ,  G01N21/01 ,  G01N21/03

    Abstract: An apparatus for thermally controlling and optically interrogating a reaction mixture includes a vessel (2) having a chamber (10) for holding the mixture. The apparatus also includes a heat-exchanging module (37) having a pair of opposing thermal plates (34A, 34B) for receiving the vessel (2) between them and for heating and/or cooling the mixture contained in the vessel. The module (37) also includes optical excitation and detection assemblies (46, 48) positioned to optically interrogate the mixture. The excitation assembly (46) includes multiple light sources (100) and a set of filters for sequentially illuminating labeled analytes in the mixture with excitation beams in multiple excitation wavelength ranges. The detection assembly (48) includes multiple detectors (102) and a second set of filters for detecting light emitted from the chamber (10) in multiple emission wavelength ranges. The optics assemblies (46, 48) thus provide a multi-channel system for detcting a plurality of different target analytes in the mixture.

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