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    MULTI-SITE REACTOR SYSTEM WITH DYNAMIC, INDEPENDENT CONTROL OF INDIVIDUAL REACTION SITES
    6.
    发明申请
    MULTI-SITE REACTOR SYSTEM WITH DYNAMIC, INDEPENDENT CONTROL OF INDIVIDUAL REACTION SITES 审中-公开
    具有独立反应场所独立控制的多场反应器系统

    公开(公告)号：WO9948608A3

    公开(公告)日：1999-12-09

    申请号：PCT/US9906628

    申请日：1999-03-23

    Applicant: CEPHEID

    Inventor： YOUNG STEVEN J ,  KOVACS GREGORY T A ,  NORTHRUP M ALLEN ,  PETERSEN KURT E ,  MCMILLAN WILLIAM A ,  OTHMER KONSTANTIN ,  CHRISTEL LEE A

    IPC: C12Q1/68 ,  B01J19/00 ,  B01L7/00 ,  G05B13/02 ,  G05D23/19

    CPC classification number: B01L7/52 ,  G05B13/021 ,  G05D23/1913

    Abstract: A multi-site reactor system (60) provides dynamic, independent, computer-implemented control of each reaction site, permitting different thermal profiles to be performed on samples at different reaction sites simultaneously. The system includes reaction vessels (2) for holding reaction mixtures and heat-exchanging modules (37) for receiving the vessels. The system also includes a controller (64) for independently controlling each heat-exchanging module (37) to heat and/or cool the reaction mixture contained therein. The controller (64) includes an adaptive control program for dynamically adjusting the duration or intensity of power pulses provided to each heating element and for dynamically adjusting the duration of fan operation to attain target temperatures quickly and accurately without overshooting or undershooting the target.

    Abstract translation: 多位点反应器系统（60）为每个反应位点提供动态，独立的计算机实现的控制，允许在不同反应位点的样品上同时进行不同的热分布。 该系统包括用于保持反应混合物的反应容器（2）和用于接收容器的热交换模块（37）。 该系统还包括用于独立地控制每个热交换模块（37）以加热和/或冷却其中包含的反应混合物的控制器（64）。 控制器（64）包括一个自适应控制程序，用于动态地调整提供给每个加热元件的功率脉冲的持续时间或强度，并且用于动态地调整风扇操作的持续时间以快速且准确地达到目标温度，而不会超标或低于目标。

    9.
    发明专利
    未知

    公开(公告)号：DK1179585T3

    公开(公告)日：2008-11-10

    申请号：DK01118242

    申请日：1998-12-24

    Applicant: CEPHEID

    Inventor： POURAHMADI FARZAD ,  CHING JESUS ,  CHANG RONALD ,  PETERSEN KURT E ,  MCMILLIAN WILLIAM A ,  CHRISTEL LEE A ,  KOVACS GREGORY T ,  NORTHRUP M ALLEN

    IPC: B01J19/00 ,  G01N31/20 ,  B01D11/00 ,  B01L3/00 ,  B01L7/00 ,  C12M1/00 ,  C12M1/26 ,  C12M1/33 ,  C12M1/34 ,  C40B60/14 ,  G01N1/28 ,  G01N30/60 ,  G01N33/50 ,  G01N35/08 ,  G01N37/00

    Abstract: A cartridge (101) for separating a desired analyte from a fluid sample includes a sample port (103) and a sample flow path extending from the port through the body of the cartridge. The sample flow path includes at least one flow-through component (122), e.g. filter paper or a microfabricated chip, for capturing the desired analyte from the sample as the sample flows through the cartridge. The cartridge also includes an elution flow path for carrying elution fluid through the component (122) to release captured analyte from the component into the elution fluid. The elution flow path diverges from the sample flow path after passing through the component (122). Flow controllers (41A and 41B) direct the remaining fluid sample into a waste chamber (139) after the sample flows through the component (122) and direct the elution fluid and eluted analyte into a reagent chamber (141) and reaction chamber (143). The continuous-flow design of the cartridge permits the rapid processing of a fluid sample that is larger in volume than any interactive region within the cartridge, allowing increased sensitivity in the detection of low copy concentrations of analytes, such as nucleic acid. A preferred embodiment relates to a device for lysing components of a fluid sample, the device comprising inter alia, an ultrasonic transducer.

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