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    Cartridge for controlling chemical reaction
    1.
    发明专利
    Cartridge for controlling chemical reaction 有权
    用于控制化学反应的墨盒

    公开(公告)号：JP2009282041A

    公开(公告)日：2009-12-03

    申请号：JP2009180791

    申请日：2009-08-03

    Applicant: Cepheid ,  セフィードCepheid

    Inventor： PETERSEN KURT E ,  MCMILLAN WILLIAM A ,  POURAHMADI FARZAD ,  CHANG RONALD ,  DORITY DOUGLAS B

    IPC: G01N33/48 ,  G01N35/02 ,  B01J19/00 ,  B01J19/24 ,  B01L3/00 ,  B01L7/00 ,  C12M1/00 ,  C12M1/26 ,  C12M1/34 ,  G01N33/483 ,  G01N35/08 ,  G01N37/00

    CPC classification number: B01L3/502 ,  B01L3/5027 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2400/0487 ,  B01L2400/0622 ,  B01L2400/0644

    Abstract: PROBLEM TO BE SOLVED: To provide a cartridge which can quickly treat a reactant mixture and improve the detection sensitivity of an analyte in the mixture. SOLUTION: This cartridge (20) for controlling a chemical reaction includes a main body with at least one internally-formed channel The cartridge extends from the main body, and further includes a reaction container (40) for holding the reactant mixture used on the chemical reaction and optical detection. The reaction container (40) has a rigid frame for partitioning sidewalls of a reaction chamber, and the frame has at least one channel for connecting the channel with the reaction chamber. Furthermore, the reaction chamber has flexible films or sheets attached to both sides of the above frame in order to form a main wall opposed to the reaction chamber. Additionally, at least two of the sidewalls are biased with respect to each other so as to be translucent and angular for enabling the real time optical detection of the analyte in the reaction chamber. COPYRIGHT: (C)2010,JPO&INPIT

    Abstract translation: 要解决的问题：提供可以快速处理反应物混合物并提高混合物中分析物的检测灵敏度的药筒。 用于控制化学反应的盒（20）包括具有至少一个内部形成的通道的主体。盒从主体延伸，并且还包括用于保持所使用的反应物混合物的反应容器（40） 对化学反应和光学检测。 反应容器（40）具有用于分隔反应室侧壁的刚性框架，框架具有用于将通道与反应室连接的至少一个通道。 此外，反应室具有附接到上述框架的两侧的柔性膜或片，以形成与反应室相对的主壁。 此外，至少两个侧壁相对于彼此被偏置，以便是半透明和有角度的，以便能够对反应室中的分析物进行实时光学检测。 版权所有（C）2010，JPO＆INPIT

    UNITARY CHEMICAL PROCESSING DEVICE
    7.
    发明申请
    UNITARY CHEMICAL PROCESSING DEVICE 审中-公开
    单位化学处理装置

    公开(公告)号：WO9947255A8

    公开(公告)日：2001-07-19

    申请号：PCT/US9906150

    申请日：1999-03-17

    Applicant: CEPHEID

    Inventor： NORTHRUP M ALLEN ,  PETERSEN KURT E ,  MCMILLAN WILLIAM A ,  KOVACS GREGORY T A

    IPC: B03C5/00 ,  B01D57/02 ,  B01J19/00 ,  B01L3/00 ,  B01L99/00 ,  G01N27/447 ,  G01N30/60

    CPC classification number: G01N27/44743 ,  B01J19/0093 ,  B01J2219/00853 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00905 ,  B01J2219/00909 ,  B01J2219/00912 ,  B01J2219/00952 ,  B01J2219/0097 ,  B01L3/50273 ,  B01L3/502746 ,  B01L3/502753 ,  B01L2300/0681 ,  B01L2300/087 ,  B01L2300/0883 ,  B01L2300/1883 ,  B01L2400/0406 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/0487 ,  B01L2400/0633 ,  B01L2400/0655 ,  G01N30/6095

    Abstract: A sample-processing device (150) comprises a unitary body (152), preferably a molded polymeric part, having formed therein a reaction chamber (154) for chemically reacting a sample, a separation region (158) for separating components of the sample, and a transition region (156) connecting the reaction chamber (154) to the separation region (158). The reaction chamber (154), transition region (156), and separation region (158) are formed in and enclosed by the unitary body (152). Additionally, the transition region (156) includes at least one flow restrictor (180) for controlling the flow of fluid between the reaction chamber (154) and the separation region (158). Further, the portion of the unitary body (152) defining the transition region (156) has lower thermal conduction than the portion of the body defining the reaction chamber (154) so that the transition region (156) thermally isolates the reaction chamber (154) from the separation region (156). In a preferred embodiment, the reaction chamber (154) is an amplification chamber for amplifying nucleic acid in the sample, and the separation region (158) comprises an electrophoresis column or capillary containing a suitable matrix material, such as electrophoresis gel or buffer, for separating nucleic acid fragments in the sample. Electrodes (167, 168, 169) are embedded in the body (152) for forcing the sample to flow from the reaction chamber (154) to the separation region (158). The unitary body (152) may also be surrounded by external, functional components such as an optical detector (186) for detecting separated components of the sample.

    Abstract translation: 样品处理装置（150）包括整体（152），优选为模制聚合物部分，其中形成有用于使样品化学反应的反应室（154），用于分离样品组分的分离区域（158） 以及将反应室（154）连接到分离区域（158）的过渡区域（156）。 反应室（154），过渡区域（156）和分离区域（158）由整体（152）形成并包围。 另外，过渡区域（156）包括用于控制反应室（154）和分离区域（158）之间的流体流动的至少一个限流器（180）。 此外，限定过渡区域（156）的整体（152）的部分具有比限定反应室（154）的主体部分更低的热传导，使得过渡区域（156）将反应室（154）热隔离 ）从分离区域（156）。 在优选的实施方案中，反应室（154）是用于放大样品中的核酸的扩增室，分离区域（158）包含电泳柱或毛细管，其含有合适的基质材料，例如电泳凝胶或缓冲液，用于 分离样品中的核酸片段。 电极（167,168,169）嵌入在主体（152）中，用于迫使样品从反应室（154）流到分离区（158）。 整体（152）也可以被诸如用于检测样品的分离组分的光学检测器（186）的外部功能部件包围。

    MULTI-SITE REACTOR SYSTEM WITH DYNAMIC, INDEPENDENT CONTROL OF INDIVIDUAL REACTION SITES
    9.
    发明申请
    MULTI-SITE REACTOR SYSTEM WITH DYNAMIC, INDEPENDENT CONTROL OF INDIVIDUAL REACTION SITES 审中-公开
    具有独立反应场所独立控制的多场反应器系统

    公开(公告)号：WO9948608A3

    公开(公告)日：1999-12-09

    申请号：PCT/US9906628

    申请日：1999-03-23

    Applicant: CEPHEID

    Inventor： YOUNG STEVEN J ,  KOVACS GREGORY T A ,  NORTHRUP M ALLEN ,  PETERSEN KURT E ,  MCMILLAN WILLIAM A ,  OTHMER KONSTANTIN ,  CHRISTEL LEE A

    IPC: C12Q1/68 ,  B01J19/00 ,  B01L7/00 ,  G05B13/02 ,  G05D23/19

    CPC classification number: B01L7/52 ,  G05B13/021 ,  G05D23/1913

    Abstract: A multi-site reactor system (60) provides dynamic, independent, computer-implemented control of each reaction site, permitting different thermal profiles to be performed on samples at different reaction sites simultaneously. The system includes reaction vessels (2) for holding reaction mixtures and heat-exchanging modules (37) for receiving the vessels. The system also includes a controller (64) for independently controlling each heat-exchanging module (37) to heat and/or cool the reaction mixture contained therein. The controller (64) includes an adaptive control program for dynamically adjusting the duration or intensity of power pulses provided to each heating element and for dynamically adjusting the duration of fan operation to attain target temperatures quickly and accurately without overshooting or undershooting the target.

    Abstract translation: 多位点反应器系统（60）为每个反应位点提供动态，独立的计算机实现的控制，允许在不同反应位点的样品上同时进行不同的热分布。 该系统包括用于保持反应混合物的反应容器（2）和用于接收容器的热交换模块（37）。 该系统还包括用于独立地控制每个热交换模块（37）以加热和/或冷却其中包含的反应混合物的控制器（64）。 控制器（64）包括一个自适应控制程序，用于动态地调整提供给每个加热元件的功率脉冲的持续时间或强度，并且用于动态地调整风扇操作的持续时间以快速且准确地达到目标温度，而不会超标或低于目标。

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