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    Cartridge for controlling chemical reaction
    1.
    发明专利
    Cartridge for controlling chemical reaction 有权
    用于控制化学反应的墨盒

    公开(公告)号：JP2009282041A

    公开(公告)日：2009-12-03

    申请号：JP2009180791

    申请日：2009-08-03

    Applicant: Cepheid ,  セフィードCepheid

    Inventor： PETERSEN KURT E ,  MCMILLAN WILLIAM A ,  POURAHMADI FARZAD ,  CHANG RONALD ,  DORITY DOUGLAS B

    IPC: G01N33/48 ,  G01N35/02 ,  B01J19/00 ,  B01J19/24 ,  B01L3/00 ,  B01L7/00 ,  C12M1/00 ,  C12M1/26 ,  C12M1/34 ,  G01N33/483 ,  G01N35/08 ,  G01N37/00

    CPC classification number: B01L3/502 ,  B01L3/5027 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2400/0487 ,  B01L2400/0622 ,  B01L2400/0644

    Abstract: PROBLEM TO BE SOLVED: To provide a cartridge which can quickly treat a reactant mixture and improve the detection sensitivity of an analyte in the mixture. SOLUTION: This cartridge (20) for controlling a chemical reaction includes a main body with at least one internally-formed channel The cartridge extends from the main body, and further includes a reaction container (40) for holding the reactant mixture used on the chemical reaction and optical detection. The reaction container (40) has a rigid frame for partitioning sidewalls of a reaction chamber, and the frame has at least one channel for connecting the channel with the reaction chamber. Furthermore, the reaction chamber has flexible films or sheets attached to both sides of the above frame in order to form a main wall opposed to the reaction chamber. Additionally, at least two of the sidewalls are biased with respect to each other so as to be translucent and angular for enabling the real time optical detection of the analyte in the reaction chamber. COPYRIGHT: (C)2010,JPO&INPIT

    Abstract translation: 要解决的问题：提供可以快速处理反应物混合物并提高混合物中分析物的检测灵敏度的药筒。 用于控制化学反应的盒（20）包括具有至少一个内部形成的通道的主体。盒从主体延伸，并且还包括用于保持所使用的反应物混合物的反应容器（40） 对化学反应和光学检测。 反应容器（40）具有用于分隔反应室侧壁的刚性框架，框架具有用于将通道与反应室连接的至少一个通道。 此外，反应室具有附接到上述框架的两侧的柔性膜或片，以形成与反应室相对的主壁。 此外，至少两个侧壁相对于彼此被偏置，以便是半透明和有角度的，以便能够对反应室中的分析物进行实时光学检测。 版权所有（C）2010，JPO＆INPIT

    10.
    发明专利
    未知

    公开(公告)号：DK1179585T3

    公开(公告)日：2008-11-10

    申请号：DK01118242

    申请日：1998-12-24

    Applicant: CEPHEID

    Inventor： POURAHMADI FARZAD ,  CHING JESUS ,  CHANG RONALD ,  PETERSEN KURT E ,  MCMILLIAN WILLIAM A ,  CHRISTEL LEE A ,  KOVACS GREGORY T ,  NORTHRUP M ALLEN

    IPC: B01J19/00 ,  G01N31/20 ,  B01D11/00 ,  B01L3/00 ,  B01L7/00 ,  C12M1/00 ,  C12M1/26 ,  C12M1/33 ,  C12M1/34 ,  C40B60/14 ,  G01N1/28 ,  G01N30/60 ,  G01N33/50 ,  G01N35/08 ,  G01N37/00

    Abstract: A cartridge (101) for separating a desired analyte from a fluid sample includes a sample port (103) and a sample flow path extending from the port through the body of the cartridge. The sample flow path includes at least one flow-through component (122), e.g. filter paper or a microfabricated chip, for capturing the desired analyte from the sample as the sample flows through the cartridge. The cartridge also includes an elution flow path for carrying elution fluid through the component (122) to release captured analyte from the component into the elution fluid. The elution flow path diverges from the sample flow path after passing through the component (122). Flow controllers (41A and 41B) direct the remaining fluid sample into a waste chamber (139) after the sample flows through the component (122) and direct the elution fluid and eluted analyte into a reagent chamber (141) and reaction chamber (143). The continuous-flow design of the cartridge permits the rapid processing of a fluid sample that is larger in volume than any interactive region within the cartridge, allowing increased sensitivity in the detection of low copy concentrations of analytes, such as nucleic acid. A preferred embodiment relates to a device for lysing components of a fluid sample, the device comprising inter alia, an ultrasonic transducer.

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